Protein Overview: CCL2_RAT

General Information:
Name(s) found:	CCL2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|3091141\|gb\|AAC15187.1\| unknown [Rattus norvegicus] [NCBI NR] gi\|205334\|gb\|AAA63496.1\| chemoattractant protein-1 [NCBI NR] gi\|149053620\|gb\|EDM05437.1\| chemokine (C-C motif) ligand 2 [Rattus norvegicus] [NCBI NR] gi\|13928714\|ref\|NP_113718.1\| small inducible cytokine A2 [Rattus norvegicus] [NCBI NR] gi\|126846\|sp\|P14844.1\|CCL2_RAT RecName: Full=C-C motif chemokine 2; AltName: Full=Small-inducible cytokine A2; AltName: Full=Monocyte chemoattractant protein 1; AltName: Full=Monocyte chemotactic protein 1; Short=MCP-1; AltName: Full=Immediate-early serum [NCBI NR] pir\|\|S07723 immediate-early serum-responsive protein JE precursor - rat [NCBI NR] (P14844) Small inducible cytokine A2 precursor (CCL2) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte chemoattractant protein-1) (Immediate-early serum-responsive JE protein) [Swiss-Prot] C-C motif chemokine 2 OS=Rattus norvegicus GN=Ccl2 PE=2 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):10_random-1907668;10-68283197 Small inducible cytokine A2 precursor [hmr_yeast5_DM3-1_pombe.fasta] small inducible cytokine A2; small inducible gene JE; monocyte chemotactic protein 1; monocyte chemoattractant protein-1 [HMR_022704-rand.fasta] small inducible cytokine A2; monocyte chemoattractant protein-1; monocyte chemotactic protein 1; small inducible gene JE [071204_hmrz_cont.fasta] small inducible cytokine A2 [Rattus norvegicus]gi\|55531\|emb\|CAA34901.1\| JE product [Rattus sp.]gi\|126846\|sp\|P14844\|SY02_RAT Small inducible cytokine A2 precursor (CCL2) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte chemoattractant protein-1) (Immed [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Small inducible cytokine A2 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_031530) small inducible cytokine A2; Small inducible gene JE [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] small inducible cytokine A2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] C-C motif chemokine 2 precursor (Small-inducible cytokine A2) (Monocyte chemoattractant protein 1) (Monocyte chemotactic protein 1) (MCP-1) (Immediate-early serum-responsive JE protein) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] chemokine (C-C motif) ligand 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] unknown [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] chemoattractant protein-1 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SMALL INDUCIBLE CYTOKINE A2 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Small inducible cytokine A2 precursor (CCL2) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte chemoattractant protein 1) (Immediate-early serum-responsive JE protein) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Ccl2 C-C motif chemokine 2 [rat-ipi-250309-contam.fasta] C-C motif chemokine 2 OS=Rattus norvegicus GN=Ccl2 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	148 amino acids
Gene Ontology:
Cellular Component:	extracellular space [UNKNOWN][IDA] cytoplasm [IDA] neuronal cell body [IDA] extracellular region [UNKNOWN][IEA]
Biological Process:	response to progesterone stimulus [IEP] transforming growth factor beta receptor signaling pathway [IMP] response to amino acid stimulus [IEP] response to antibiotic [IEP] response to mechanical stimulus [IEP] chemotaxis [IEA] response to ethanol [IEP] inflammatory response [IEP] response to heat [IDA] response to hypoxia [IEP] immune response [IEA] anti-apoptosis [UNKNOWN][IEA] lymphocyte chemotaxis [IDA] macrophage chemotaxis [UNKNOWN][IDA] cytokine-mediated signaling pathway [UNKNOWN][IMP] response to glucocorticoid stimulus [IEP] response to vitamin B3 [IEP] response to gamma radiation [IEP] positive regulation of synaptic transmission [IDA] chemokinesis [TAS] maternal process involved in parturition [IEP] cellular calcium ion homeostasis [IDA] response to bacterium [UNKNOWN][IEA] vascular endothelial growth factor receptor signaling pathway [IMP] monocyte chemotaxis [UNKNOWN][IEA] response to drug [IEP] chemokine-mediated signaling pathway [IMP] neutrophil chemotaxis [IMP] response to lipopolysaccharide [IEP] positive regulation of endothelial cell proliferation [IMP] response to activity [IEP] organ regeneration [IEP]
Molecular Function:	G-protein-coupled receptor binding [UNKNOWN][IEA] protein binding [UNKNOWN][IEA] CCR2 chemokine receptor binding [IMP] heparin binding [IPI] chemokine activity [IDA][NAS][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQVSVTLLGL LFTVAACSIH VLSQPDAVNA PLTCCYSFTG KMIPMSRLEN YKRITSSRCP  60
   61 KEAVVFVTKL KREICADPNK EWVQKYIRKL DQNQVRSETT VFYKIASTLR TSAPLNVNLT 120
  121 HKSEANASTL FSTTTSSTSV EVTSMTEN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..148]	PSI-BLAST	19.30103	MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE

Protein Overview: CCL2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: