Protein Overview: ADA17_RAT

General Information:
Name(s) found:	ADA17_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|9945330\|ref\|NP_064702.1\| a disintegrin and metalloprotease domain 17 [Rattus norvegicus] [NCBI NR] gi\|3859107\|emb\|CAA10072.1\| TNF-alpha converting enzyme (TACE) [Rattus norvegicus] [NCBI NR] gi\|14423630\|sp\|Q9Z1K9.1\|ADA17_RAT RecName: Full=Disintegrin and metalloproteinase domain-containing protein 17; Short=ADAM 17; AltName: Full=TNF-alpha-converting enzyme; AltName: Full=TNF-alpha convertase; AltName: CD_antigen=CD156b; Flags: Precursor [NCBI NR] Disintegrin and metalloproteinase domain-containing protein 17 OS=Rattus norvegicus GN=Adam17 PE=1 SV=1 [Swiss-Prot] (Q9Z1K9) ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha converting enzyme) (TNF-alpha convertase) [Swiss-Prot] Ensembl_locations(Chr-bp):6-34542120;6-34542120;6-34542120;6-34542120 ADAM 17 precursor [hmr_yeast5_DM3-1_pombe.fasta] a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme [HMR_022704-rand.fasta] a disintegrin and metalloprotease domain 17 [Rattus norvegicus]gi\|3859107\|emb\|CAA10072.1\| TNF-alpha converting enzyme (TACE) [Rattus norvegicus]gi\|14423630\|sp\|Q9Z1K9\|AD17_RAT ADAM 17 precursor (A disintegrin and metalloproteinase domain 17) (TNF-alpha c [nrdb_11152004_Chlamydomonas] Tax_Id=10116 ADAM 17 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_020306) a disintegrin and metalloprotease domain 17; TNF-alpha converting enzyme [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] a disintegrin and metalloprotease domain 17 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] ADAM 17 precursor (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (CD156b antigen) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] TNF-alpha converting enzyme (TACE) [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 ADAM 17 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Adam17 ADAM 17 [rat-ipi-250309-contam.fasta] Disintegrin and metalloproteinase domain-containing protein 17 OS=Rattus norvegicus GN=Adam17 [011711_HMR.fasta] Disintegrin and metalloproteinase domain-containing protein 17 OS=Rattus norvegicus GN=Adam17 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	827 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [UNKNOWN][IEA] cell-cell junction [UNKNOWN][IEA] focal adhesion [UNKNOWN][IEA] cytoplasm [UNKNOWN][IEA] membrane [IEA] membrane raft [UNKNOWN][IEA] actin cytoskeleton [UNKNOWN][IEA] ruffle membrane [UNKNOWN][IEA] plasma membrane [IDA] apical plasma membrane [UNKNOWN][IEA] cell surface [UNKNOWN][IEA]
Biological Process:	epidermal growth factor receptor signaling pathway [UNKNOWN][IEA] membrane protein intracellular domain proteolysis [UNKNOWN] response to high density lipoprotein stimulus [UNKNOWN][IEA] positive regulation of cell proliferation [UNKNOWN][IEA] cell adhesion [UNKNOWN] positive regulation of epidermal growth factor receptor activity [UNKNOWN][IEA] positive regulation of cyclin-dependent protein kinase activity involved in G1/S [UNKNOWN][IEA] response to bacterium [UNKNOWN][IEA] positive regulation of cell growth [UNKNOWN][IEA] cell adhesion mediated by integrin [UNKNOWN][IEA] response to hypoxia [UNKNOWN][IEA] Notch signaling pathway [IEA] membrane protein ectodomain proteolysis [UNKNOWN][IMP][TAS] anti-apoptosis [IDA] PMA-inducible membrane protein ectodomain proteolysis [UNKNOWN][IEA] negative regulation of interleukin-8 production [UNKNOWN][IEA] positive regulation of protein amino acid phosphorylation [UNKNOWN][IEA] proteolysis [IEA][TAS] positive regulation of T cell chemotaxis [UNKNOWN][IEA] response to lipopolysaccharide [UNKNOWN][IEA] positive regulation of chemokine production [UNKNOWN][IEA] wound healing, spreading of epidermal cells [UNKNOWN][IEA] positive regulation of cell migration [UNKNOWN][IEA]
Molecular Function:	zinc ion binding [IEA] protein binding [UNKNOWN][IEA] metal ion binding [IEA] PDZ domain binding [UNKNOWN][IEA] integrin binding [UNKNOWN][IEA] peptidase activity [IEA] SH3 domain binding [UNKNOWN][IEA] metalloendopeptidase activity [UNKNOWN][IEA][IMP] interleukin-6 receptor binding [UNKNOWN][IEA] metallopeptidase activity [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRQRLLFLTT LVPFVLAPRP PEEPGSGSHL RLEKLDSLLS DYDILSLSNI QQHSIRKRDL  60
   61 QSATHLETLL TFSALKRHFK LYLTSSTERF SQNLRVVVVD GKEESEYSVK WQDFFSGHVV 120
  121 GEPDSRVLAH IGDDDVTVRI NTDGAEYNIE PLWRFVNDTK DKRMLVYKSE DIKDFSRLQS 180
  181 PKVCGYLNAD SEELLPKGLI DREPSEEFVR RVKRRAEPNP LKNTCKLLVV ADHRFYKYMG 240
  241 RGEESTTTNY LIELIDRVDD IYRNTSWDNA GFKGYGVQIE QIRILKSPQE VKPGERHFNM 300
  301 AKSFPNEEKD AWDVKMLLEQ FSLDIAEEAS KVCLAHLFTY QDFDMGTLGL AYVGSPRANS 360
  361 HGGVCPKAYY NPGVKKNIYL NSGLTSTKNY GKTILTKEAD LVTTHELGHN FGAEHDPDGL 420
  421 AECAPNEDQG GKYVMYPIAV SGDHENNKMF SNCSKQSIYK TIESKAQECF QERSNKVCGN 480
  481 SRVDEGEECD PGIMYLNNDT CCNSDCTLKP GVQCSDRNSP CCKNCQFETA QKKCQEAINA 540
  541 TCKGVSYCTG NSSECPPPGD AEDDTVCLDL GKCKAGKCIP FCKREQELES CACADTDNSC 600
  601 KVCCRNLSGP CVPYVDAEQK NLFLRKGKPC TVGFCDMNGK CEKRVQDVIE RFWDFIDQLS 660
  661 INTFGKFLAD NIVGSVLVFS LIFWIPFSIL VHCVDKKLDK QYESLSLFHH SNIEMLSSMD 720
  721 SASVRIIKPF PAPQTPGRLQ ALQPAAMMPP VSAAPKLDHQ RMDTIQEDPS TDSHVDDDGF 780
  781 EKDPFPNSSA AAKSFEDLTD HPVTRSEKAA SFKLQRQSRV DSKETEC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: ADA17_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: