Protein Overview: WT1_RAT

General Information:
Name(s) found:	WT1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|407865\|emb\|CAA49373.1\| Wilms' Tumor [Rattus norvegicus] [NCBI NR] gi\|1722850\|sp\|P49952.1\|WT1_RAT RecName: Full=Wilms tumor protein homolog [NCBI NR] gi\|13928720\|ref\|NP_113722.1\| wilms tumor 1 [Rattus norvegicus] [NCBI NR] Wilms tumor protein homolog OS=Rattus norvegicus GN=Wt1 PE=2 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):3-84607941 Splice isoform 1 of P49952 [hmr_yeast5_DM3-1_pombe.fasta] wilms tumor 1 [HMR_022704-rand.fasta] wilms tumor 1 [Rattus norvegicus]gi\|407865\|emb\|CAA49373.1\| Wilms' Tumor [Rattus norvegicus]gi\|1722850\|sp\|P49952\|WT1_RAT Wilms' tumor protein homolog [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Splice Isoform 1 of Wilms' tumor protein homolog [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_031534) wilms tumor 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Wilms tumor protein homolog [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Wilms' Tumor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SPLICE ISOFORM 1 OF WILMS' TUMOR PROTEIN HOMOLOG [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Wilms' tumor protein homolog [nr-271106-contam.fasta] wilms tumor 1 [Rattus norvegicus] [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Wt1 Isoform 1 of Wilms tumor protein homolog [rat-ipi-250309-contam.fasta] Isoform 1 of Wilms tumor protein homolog OS=Rattus norvegicus GN=Wt1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	448 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN][IDA][IEA][ISS] cytoplasm [UNKNOWN][IEA] nuclear speck [UNKNOWN][ISS] intracellular [IEA] nucleoplasm [UNKNOWN][IEA]
Biological Process:	RNA splicing [IEA] male gonad development [UNKNOWN][IEA] negative regulation of cell proliferation [UNKNOWN][ISS] positive regulation of transcription [UNKNOWN][ISS] vasculogenesis [UNKNOWN][IEA] sex determination [UNKNOWN][IEA] positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IMP] negative regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA] heart development [UNKNOWN][IEA] positive regulation of gene-specific transcription [UNKNOWN][ISS] kidney development [UNKNOWN] induction of apoptosis [UNKNOWN] negative regulation of cell growth [UNKNOWN][ISS] mesonephros development [UNKNOWN][IEA] camera-type eye development [UNKNOWN][IEA] negative regulation of translation [UNKNOWN] adrenal gland development [UNKNOWN][IEA] germ cell development [UNKNOWN][IEA] mesenchymal to epithelial transition [IEA] negative regulation of gene-specific transcription [UNKNOWN][ISS] regulation of transcription, DNA-dependent [UNKNOWN][IEA] tissue development [UNKNOWN][IEA] regulation of transcription from RNA polymerase II promoter [UNKNOWN] epithelial cell differentiation [IEA] glomerular basement membrane development [UNKNOWN][ISS] glomerulus development [UNKNOWN] metanephros development [UNKNOWN] ureteric bud development [IEA] male genitalia development [IEA] branching involved in ureteric bud morphogenesis [UNKNOWN][IEA] negative regulation of transcription [UNKNOWN][ISS] negative regulation of apoptosis [UNKNOWN][IEA]
Molecular Function:	zinc ion binding [UNKNOWN][IEA][ISS] double-stranded DNA binding [UNKNOWN][IEA] sequence-specific DNA binding [UNKNOWN][IDA][ISS] nucleic acid binding [IEA] transcription factor activity [IEA] RNA binding [UNKNOWN][IEA] protein binding [UNKNOWN][IPI] metal ion binding [IEA] C2H2 zinc finger domain binding [UNKNOWN][ISS] promoter binding [UNKNOWN][ISS] [NOT]transcription activator activity [UNKNOWN][IDA][ISS] transcription repressor activity [UNKNOWN][ISS] specific transcriptional repressor activity [UNKNOWN][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSDVRDLNA LLPAVSSLGG GGGCGLPVSG ARQWAPVLDF APPGASAYGS LGGPAPPPAP  60
   61 PPPPPPPHSF IKQEPSWGGA EPHEEQCLSA FTLHFSGQFT GTAGACRYGP FGPPPPSQAS 120
  121 SGQARMFPNA PYLPSCLESQ PSIRNQGYST VTFDGAPSYG HTPSHHAAQF PNHSFKHEDP 180
  181 MGQQGSLGEQ QYSVPPPVYG CHTPTDSCTG SQALLLRTPY SSDNLYQMTS QLECMTWNQM 240
  241 NLGATLKGMA AGSSSSVKWT EGQSNHGTGY ESENHTTPIL CGAQYRIHTH GVFRGIQDVR 300
  301 RVSGVAPTLV RSASETSEKR PFMCAYPGCN KRYFKLSHLQ MHSRKHTGEK PYQCDFKDCE 360
  361 RRFSRSDQLK RHQRRHTGVK PFQCKTCQRK FSRSDHLKTH TRTHTGKTSE KPFSCRWHSC 420
  421 QKKFARSDEL VRHHNMHQRN MTKLHVAL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: WT1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: