Protein Overview: NEC1_RAT

General Information:
Name(s) found:	NEC1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|8393919\|ref\|NP_058787.1\| proprotein convertase subtilisin/kexin type 1 [Rattus norvegicus] [NCBI NR] pir\|\|KXRTC1 proprotein convertase 1 (EC 3.4.21.93) precursor - rat [NCBI NR] gi\|203509\|gb\|AAA40945.1\| hormone convertase [NCBI NR] gi\|149058898\|gb\|EDM09905.1\| proprotein convertase subtilisin/kexin type 1 [Rattus norvegicus] [NCBI NR] gi\|128001\|sp\|P28840.1\|NEC1_RAT RecName: Full=Neuroendocrine convertase 1; Short=NEC 1; AltName: Full=Prohormone convertase 1; AltName: Full=Proprotein convertase 1; Short=PC1; Flags: Precursor [NCBI NR] Neuroendocrine convertase 1 OS=Rattus norvegicus GN=Pcsk1 PE=2 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):2-504841 Neuroendocrine convertase 1 precursor [hmr_yeast5_DM3-1_pombe.fasta] proprotein convertase subtilisin/kexin type 1; Protein convertase subtilisin / kexin, type I; prohormone convertase 3; Protein convertase subtilisin / kexin type I [HMR_022704-rand.fasta] proprotein convertase subtilisin/kexin type 1 [Rattus norvegicus]gi\|67639\|pir\|\|KXRTC1 proprotein convertase 1 (EC 3.4.21.93) precursor - ratgi\|128001\|sp\|P28840\|NEC1_RAT Neuroendocrine convertase 1 precursor (NEC 1) (PC1) (Prohormone convertase 1) (Propr [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Neuroendocrine convertase 1 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_017091) protein convertase subtilisin / kexin, type I [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Neuroendocrine convertase 1 precursor (NEC 1) (Prohormone convertase 1) (Proprotein convertase 1) (PC1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] proprotein convertase subtilisin/kexin type 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] hormone convertase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 NEUROENDOCRINE CONVERTASE 1 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Neuroendocrine convertase 1 precursor (NEC 1) (PC1) (Prohormone convertase 1) (Proprotein convertase 1) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Pcsk1 Neuroendocrine convertase 1 [rat-ipi-250309-contam.fasta] Neuroendocrine convertase 1 OS=Rattus norvegicus GN=Pcsk1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	752 amino acids
Gene Ontology:
Cellular Component:	dendrite [IDA] extracellular space [UNKNOWN][IDA] trans-Golgi network [IDA] perinuclear region of cytoplasm [IDA] secretory granule [IDA] rough endoplasmic reticulum [IDA] cytoplasmic vesicle [IEA] transport vesicle [IEA] neuronal cell body [IDA] neuron projection [IDA] axon terminus [IDA]
Biological Process:	embryonic development [IEP] neurogenesis [IEP] response to axon injury [IEP] response to organic cyclic substance [IEP] response to morphine [IEP] response to peptide hormone stimulus [IEP] pituitary gland development [IEP] response to glucose stimulus [IEP] response to drug [IEP] response to calcium ion [IEP] proteolysis [IMP] peptide biosynthetic process [IEA] response to glucocorticoid stimulus [IEP] response to interleukin-1 [IEP] protein autoprocessing [IMP] response to lipopolysaccharide [IEP] response to fatty acid [IEP] peptide hormone processing [IDA][IMP] positive regulation of protein secretion [IDA][IMP] response to inorganic substance [IEP] response to protein stimulus [IEP] response to nutrient levels [IEP] response to chlorate [IEP] pancreas development [IEP]
Molecular Function:	insulin binding [IPI] chaperone binding [IPI] endopeptidase activity [IDA][IMP] serine-type endopeptidase activity [IEA] peptidase activity [IEA] protein complex binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKQRGWTLQC TAFTLFCVWC ALNSVKAKRQ FVNEWAAEIH GGPEAASAIA EELGYDLLGQ  60
   61 IGSLENHYLF KHKNHPRRSR RSALHITKRL SDDDRVIWAE QQYEKERRKR SVPRDSALNL 120
  121 FNDPMWNQQW YLQDTRMTAS LPKLDLHVIP VWQKGITGKG VVITVLDDGL EWNHTDIYAN 180
  181 YDPEASYDFN DNDHDPFPRY DPTNENKHGT RCAGEIAMQA NNHKCGVGVA YNSKVGGIRM 240
  241 LDGIVTDAIE ASSIGFNPGH VDIYSASWGP NDDGKTVEGP GRLAQKAFEY GVKQGRQGKG 300
  301 SIFVWASGNG GRQGDNCDCD GYTDSIYTIS ISSASQQGLS PWYAEKCSST LATSYSSGDY 360
  361 TDQRITSADL HNDCTETHTG TSASAPLAAG IFALALEANP NLTWRDMQHL VVWTSEYDPL 420
  421 ANNPGWKKNG AGLMVNSRFG FGLLNAKALV DLADPRTWRN VPEKKECIIK DNNFEPRALK 480
  481 ANGEVIVEIP TRACEGQENA INSLEHVQFE ATIEYSRRGD LHVTLTSAAG TSTVLLAERE 540
  541 RDTSPNGFKN WDFMSVHTWG ENPVGTWTLK VTDMSGRMQN EGRIVNWKLI LHGTSSQPEH 600
  601 MKQPRVYTSY NTVQNDRRGV EKMVNVVEEK PTQNSLNGNL LVPKNSSSSS VEDRRDEQVQ 660
  661 GAPSKAMLRL LQSAFSKNTP SKQSSKIPSA KLSVPYEGLY EALEKLNKPS QLEDSEDSLY 720
  721 SDYVDVFYNT KPYKHRDDRL LQALMDILNE KN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: NEC1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: