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Protein Overview: FAK2_RAT

General Information:
Name(s) found: FAK2_RAT [Swiss-Prot]
Description(s) found:
Found 18 descriptions.
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  • Protein-tyrosine kinase 2-beta OS=Rattus norvegicus GN=Ptk2b PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 1009 amino acids

    Gene Ontology:
    Cellular Component: growth cone [IDA]
    nucleus [IDA]
    postsynaptic density [IDA]
    cytoskeleton [IEA]
    perinuclear region of cytoplasm [IDA]
    focal adhesion [IDA]
    cytoplasm [IEA]
    cell cortex [IDA]
    membrane raft [IDA]
    cell junction [IEA]
    plasma membrane [IEA]
    axon [IDA]
    Biological Process: activation of Janus kinase activity [IMP]
    signal complex assembly [IEA]
    peptidyl-tyrosine phosphorylation [IDA]
    positive regulation of JUN kinase activity [IMP]
    positive regulation of translation [IMP]
    epidermal growth factor receptor signaling pathway [IMP]
    positive regulation of cell proliferation [IEP]
    actin filament organization [IMP]
    response to cAMP [IEP]
    cell adhesion [IMP]
    protein amino acid phosphorylation [UNKNOWN]
    stress fiber assembly [IMP]
    positive regulation of anti-apoptosis [IMP]
    response to mechanical stimulus [IEP]
    MAPKKK cascade [IMP]
    response to ethanol [IEP]
    response to glucose stimulus [IEP]
    positive regulation of cell growth [IMP]
    response to hypoxia [IEP]
    angiogenesis [IMP]
    focal adhesion assembly [IMP]
    activation of Rac GTPase activity [IMP]
    neuron projection development [IMP]
    response to osmotic stress [IEP]
    response to cocaine [IEP]
    response to hydrogen peroxide [IPI]
    response to reactive oxygen species [IEP]
    response to hormone stimulus [IEP]
    blood vessel endothelial cell migration [IMP]
    response to stress [IEP]
    elevation of cytosolic calcium ion concentration [IMP]
    oxygen and reactive oxygen species metabolic process [IMP]
    oocyte maturation [IMP]
    response to drug [IEP]
    response to calcium ion [IEP]
    response to lithium ion [IEP]
    cell differentiation [IEP]
    glial cell proliferation [IEP]
    negative regulation of ossification [IMP]
    response to organic nitrogen [IEP]
    positive regulation of cell migration [IMP]
    Molecular Function: nucleotide binding [IEA]
    ATP binding [IEA]
    protein binding [UNKNOWN][IEA][IPI]
    non-membrane spanning protein tyrosine kinase activity [IEA]
    protein kinase activity [UNKNOWN]
    transferase activity [IEA]
    protein complex binding [IPI]
    signal transducer activity [IEA]
    3-phosphoinositide-dependent protein kinase binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGVSEPLSR VKVGTLRPPE GPPEPMVVVP VDVEKEDVRI LKVCFYSNSF NPGKNFKLVK  60
   61 CTVQTEIQEI ITSILLSGRI GPNIQLAECY GLRLKHMKSD EIHWLHPQMT VGEVQDKYEC 120
  121 LHVEAEWRYD LQIRYLPEDF MESLKEDRTT LLYFYQQLRN DYMQRYASKV SEGMALQLGC 180
  181 LELRRFFKDM PHNALDKKSN FELLEKEVGL DLFFPKQMQE NLKPKQFRKM IQQTFQQYAS 240
  241 LREEECVMKF FNTLAGFANI DQETYRCELI QGWNITVDLV IGPKGIRQLT SQDTKPTCLA 300
  301 EFKQIRSIRC LPLEETQAVL QLGIEGAPQS LSIKTSSLAE AENMADLIDG YCRLQGEHKG 360
  361 SLIIHAKKDG EKRNSLPQIP TLNLESRRSH LSESCSIESD IYAEIPDETL RRPGGPQYGV 420
  421 AREDVVLNRI LGEGFFGEVY EGVYTNHKGE KINVAVKTCK KDCTLDNKEK FMSEAVIMKN 480
  481 LDHPHIVKLI GIIEEEPTWI VMELYPYGEL GHYLERNKNS LKVPTLVLYA LQICKAMAYL 540
  541 ESINCVHRDI AVRNILVASP ECVKLGDFGL SRYIEDEDYY KASVTRLPIK WMSPESINFR 600
  601 RFTTASDVWM FAVCMWEILS FGKQPFFWLE NKDVIGVLEK GDRLPKPELC PPVLYTLMTR 660
  661 CWDYDPSDRP RFTELVCSLS DIYQMERDIA IEQERNARYR PPKILEPTAF QEPPPKPSRP 720
  721 KYKHPPQTNL LAPKLQFQVP EGLCASSPTL TSPMEYPSPV NSLHTPPLHR HNVFKRHSMR 780
  781 EEDFIRPSSR EEAQQLWEAE KIKMRQVLDR QQKQMVEDSQ WLRREERCLD PMVYMNDKSP 840
  841 LTPEKEAGYT EFTGPPQKPP RLGAQSIQPT ANLDRTDDLV YHNVMTLVEA VLELKNKLSQ 900
  901 LPPEEYVVVV KNVGLNLRKL IGSVDDLLPS LPASSRTEIE GTQKLLNKDL AELINKMRLA 960
  961 QQNAVTSLSE DCKRQMLTAS HTLAVDAKNL LDAVDQAKVV ANLAHPPAE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle