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The aggregation, arrangement and bonding together of a set of components to form a protein complex. The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. Complex formation involves dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors. Grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response. The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand. The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: signal complex assembly
Acc: GO:0007172
Aspect: Biological Process
Desc: The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. Complex formation involves dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors.
Synonyms:
  • signal complex formation
Proteins in PDR annotated with:
   This term: 17 [Search]
   Term or descendants: 55 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007172 - signal complex assembly (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle