Protein Overview: CASP8_RAT

General Information:
Name(s) found:	CASP8_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|9454380\|gb\|AAF87778.1\|AF279308_1 caspase-8 [Rattus norvegicus] [NCBI NR] gi\|15077072\|gb\|AAK83055.1\| caspase-8 [Rattus norvegicus] [NCBI NR] gi\|149046086\|gb\|EDL98979.1\| caspase 8, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149046085\|gb\|EDL98978.1\| caspase 8, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|11560103\|ref\|NP_071613.1\| caspase 8 [Rattus norvegicus] [NCBI NR] Caspase-8 OS=Rattus norvegicus GN=Casp8 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):9-62525562;9-62576373 Caspase-8 [hmr_yeast5_DM3-1_pombe.fasta] caspase-8 [HMR_022704-rand.fasta] caspase-8 [Rattus norvegicus]gi\|15077072\|gb\|AAK83055.1\| caspase-8 [Rattus norvegicus]gi\|9454380\|gb\|AAF87778.1\| caspase-8 [Rattus norvegicus] [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Caspase-8 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_022277) caspase-8 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] caspase 8 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] caspase 8, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] caspase-8 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 CASPASE-8 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Casp8 Caspase-8 [rat-ipi-250309-contam.fasta] Caspase 8, isoform CRA_a OS=Rattus norvegicus GN=Casp8 [011711_HMR.fasta] Caspase 8, isoform CRA_a OS=Rattus norvegicus GN=Casp8 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta] Caspase 8, isoform CRA_a OS=Rattus norvegicus GN=Casp8 PE=1 SV=1 [20141208_RAT.fasta]
Organism:	Rattus norvegicus
Length:	482 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN][IEA] cytoplasm [UNKNOWN][IEA] mitochondrion [UNKNOWN][IEA] Noc1p-Noc2p complex [UNKNOWN][IEA] membrane raft [IDA] cytosol [UNKNOWN][IDA] death-inducing signaling complex [UNKNOWN][IEA] protein complex [IDA] mitochondrial outer membrane [UNKNOWN]
Biological Process:	positive regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN][IEA] response to antibiotic [IEP] regulation of apoptosis [IEA] protein heterooligomerization [IDA] induction of apoptosis by extracellular signals [UNKNOWN][IEA] activation of pro-apoptotic gene products [UNKNOWN] heart development [UNKNOWN][IEA] response to cold [IEP] response to ethanol [IDA] neural tube formation [UNKNOWN][IEA] angiogenesis [UNKNOWN][IEA] proteolysis [UNKNOWN] apoptosis [UNKNOWN][IMP] response to cobalt ion [IEP] response to estradiol stimulus [IEP] response to lipopolysaccharide [IEP] proteolysis involved in cellular protein catabolic process [UNKNOWN][IEA] macrophage differentiation [UNKNOWN][IEA] response to tumor necrosis factor [UNKNOWN][IEA]
Molecular Function:	identical protein binding [UNKNOWN][IEA] protein binding [UNKNOWN] cysteine-type endopeptidase activity [UNKNOWN][IEA] peptidase activity [UNKNOWN][IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFHSCLYDI AERLGNEELA ALKFLCLDHI PQKKQESIND VLVLFQRLQE EGMLEEDNLS  60
   61 FLKELLFHIS RRDLLSRVLK SSPEEMVREL QVLGKAQVSA YRVMLFKLSE DMDKEDLKSF 120
  121 KFLLITEIPK CKLQDNSSLL DIFVEMEKRT ILAENNLVTL KSICFRVNRS LLGRIDDYER 180
  181 SSTERRMSTE GGEELPVSVL DEVTIKMQDM WDSPGEQESE SLNSDNVYQM KSKPRGYCLI 240
  241 FNNNNFSKAR EDIPKLSNMR DRKGTNYDEE ALSKTFKELH FEIVSFSDCT ASQIHEVLVS 300
  301 YQSKDHKGKD CFICCILSHG DKGIVYGTDG KEASIYELTS YFTGSKCPSL AGKPKIFFIQ 360
  361 ACQGNNFQKA VPVPDETGLE QEHVLEEDSS SYKNYIPDEA DFLLGMATVK NCVSYRDPTR 420
  421 GTWYIQSLCQ SLRERCPRGE DILSILTGVN YDVSNKDNPR NMGKQMPQPI FTLRKKLFFP 480
  481 PN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: CASP8_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: