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Protein Overview: CASP8_RAT

General Information:
Name(s) found: CASP8_RAT [Swiss-Prot]
Description(s) found:
Found 19 descriptions.
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  • Caspase-8 OS=Rattus norvegicus GN=Casp8 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 482 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IEA]
    cytoplasm [UNKNOWN][IEA]
    mitochondrion [UNKNOWN][IEA]
    Noc1p-Noc2p complex [UNKNOWN][IEA]
    membrane raft [IDA]
    cytosol [UNKNOWN][IDA]
    death-inducing signaling complex [UNKNOWN][IEA]
    protein complex [IDA]
    mitochondrial outer membrane [UNKNOWN]
    Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade [UNKNOWN][IEA]
    response to antibiotic [IEP]
    regulation of apoptosis [IEA]
    protein heterooligomerization [IDA]
    induction of apoptosis by extracellular signals [UNKNOWN][IEA]
    activation of pro-apoptotic gene products [UNKNOWN]
    heart development [UNKNOWN][IEA]
    response to cold [IEP]
    response to ethanol [IDA]
    neural tube formation [UNKNOWN][IEA]
    angiogenesis [UNKNOWN][IEA]
    proteolysis [UNKNOWN]
    apoptosis [UNKNOWN][IMP]
    response to cobalt ion [IEP]
    response to estradiol stimulus [IEP]
    response to lipopolysaccharide [IEP]
    proteolysis involved in cellular protein catabolic process [UNKNOWN][IEA]
    macrophage differentiation [UNKNOWN][IEA]
    response to tumor necrosis factor [UNKNOWN][IEA]
    Molecular Function: identical protein binding [UNKNOWN][IEA]
    protein binding [UNKNOWN]
    cysteine-type endopeptidase activity [UNKNOWN][IEA]
    peptidase activity [UNKNOWN][IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFHSCLYDI AERLGNEELA ALKFLCLDHI PQKKQESIND VLVLFQRLQE EGMLEEDNLS  60
   61 FLKELLFHIS RRDLLSRVLK SSPEEMVREL QVLGKAQVSA YRVMLFKLSE DMDKEDLKSF 120
  121 KFLLITEIPK CKLQDNSSLL DIFVEMEKRT ILAENNLVTL KSICFRVNRS LLGRIDDYER 180
  181 SSTERRMSTE GGEELPVSVL DEVTIKMQDM WDSPGEQESE SLNSDNVYQM KSKPRGYCLI 240
  241 FNNNNFSKAR EDIPKLSNMR DRKGTNYDEE ALSKTFKELH FEIVSFSDCT ASQIHEVLVS 300
  301 YQSKDHKGKD CFICCILSHG DKGIVYGTDG KEASIYELTS YFTGSKCPSL AGKPKIFFIQ 360
  361 ACQGNNFQKA VPVPDETGLE QEHVLEEDSS SYKNYIPDEA DFLLGMATVK NCVSYRDPTR 420
  421 GTWYIQSLCQ SLRERCPRGE DILSILTGVN YDVSNKDNPR NMGKQMPQPI FTLRKKLFFP 480
  481 PN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle