Protein Overview: VGFR2_RAT

General Information:
Name(s) found:	VGFR2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|9087209\|sp\|O08775.1\|VGFR2_RAT RecName: Full=Vascular endothelial growth factor receptor 2; Short=VEGFR-2; AltName: Full=Protein-tyrosine kinase receptor flk-1; AltName: Full=Fetal liver kinase 1; AltName: CD_antigen=CD309; Flags: Precursor [NCBI NR] gi\|6981128\|ref\|NP_037194.1\| kinase insert domain protein receptor [Rattus norvegicus] [NCBI NR] gi\|2098759\|gb\|AAB97508.1\| VEGF receptor-2/FLK-1 [Rattus norvegicus] [NCBI NR] (O08775) Vascular endothelial growth factor receptor 2 precursor (EC 2.7.1.112) (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) [Swiss-Prot] Vascular endothelial growth factor receptor 2 OS=Rattus norvegicus GN=Kdr PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):None Vascular endothelial growth factor receptor 2 precursor [hmr_yeast5_DM3-1_pombe.fasta] kinase insert domain protein receptor; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2) [HMR_022704-rand.fasta] kinase insert domain protein receptor [Rattus norvegicus]gi\|9087209\|sp\|O08775\|VGR2_RAT Vascular endothelial growth factor receptor 2 precursor (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1)gi\|2098759\|gb\|AAB97508.1\| VEGF recept [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Vascular endothelial growth factor receptor 2 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_013062) FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] kinase insert domain protein receptor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Vascular endothelial growth factor receptor 2 precursor (VEGFR-2) (Protein-tyrosine kinase receptor flk-1) (Fetal liver kinase 1) (CD309 antigen) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] VEGF receptor-2/FLK-1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Kdr Vascular endothelial growth factor receptor 2 [rat-ipi-250309-contam.fasta] Vascular endothelial growth factor receptor 2 OS=Rattus norvegicus GN=Kdr [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	1343 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] integral to plasma membrane [IEA] cytoplasm [IDA] neuronal cell body [IDA] neuron projection [IDA] plasma membrane [IDA]
Biological Process:	regulation of cell shape [UNKNOWN] neuroprotection [IMP] positive regulation of phosphoinositide 3-kinase cascade [IMP] calcium ion homeostasis [UNKNOWN] male gonad development [IDA] multicellular organismal development [IEA] positive regulation of vasodilation [IGI] hemopoiesis [UNKNOWN] positive regulation of cell proliferation [UNKNOWN][IMP] neuron projection morphogenesis [IMP] endothelial cell differentiation [UNKNOWN] protein amino acid autophosphorylation [IDA] vasculogenesis [UNKNOWN] branching morphogenesis of a tube [UNKNOWN] surfactant homeostasis [UNKNOWN] positive regulation of angiogenesis [IDA] positive regulation of calcium-mediated signaling [IMP] lung alveolus development [UNKNOWN] response to hypoxia [IMP] positive regulation of endothelial cell migration [UNKNOWN] cell migration [UNKNOWN] positive regulation of TOR signaling pathway [IMP] positive regulation of epithelial cell proliferation [UNKNOWN] lung development [UNKNOWN] positive regulation of positive chemotaxis [UNKNOWN] response to chemical stimulus [IDA] positive regulation of mesenchymal cell proliferation [UNKNOWN] cell maturation [UNKNOWN] ovarian follicle development [UNKNOWN] elevation of cytosolic calcium ion concentration [IMP] vascular endothelial growth factor receptor signaling pathway [UNKNOWN][IMP] positive regulation of focal adhesion assembly [UNKNOWN] response to drug [IMP] cell fate commitment [UNKNOWN] cell differentiation [IEA] positive regulation of endothelial cell proliferation [UNKNOWN][IMP] positive regulation of neurogenesis [IEP] positive regulation of cell migration [UNKNOWN][IMP] positive regulation of long-term neuronal synaptic plasticity [IMP]
Molecular Function:	nucleotide binding [IEA] ATP binding [IEA] growth factor binding [UNKNOWN][IMP][IPI] protein binding [UNKNOWN][IPI] vascular endothelial growth factor receptor activity [UNKNOWN][IMP] integrin binding [UNKNOWN] receptor activity [IEA] transferase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
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    1 MESRALLAVA LWFCVETRAA SVGLPGDSLH PPKLSTQKDI LTILANTTLQ ITCRGQRDLD  60
   61 WLWPNTPRDS EERVLVTECG DSIFCKTLTV PRVVGNDTGA YKCFYRDTDV SSIVYVYVQD 120
  121 HRSPFIASVS DEHGIVYITE NKNKTVVIPC RGSISNLNVS LCARYPEKRF VPDGNRISWD 180
  181 SEKGFTIPSY MISYAGMVFC EAKINDETYQ SIMYIVLVVG YRIYDVVLSP PHEIELSAGE 240
  241 KLVLNCTART ELNVGLDFSW QFPSSKHQHK KIVNRDVKSL PGTVAKMFLS TLTIDSVTKS 300
  301 DQGEYTCTAY SGLMTKKNKT FVRVHTKPFI AFGSGMKSLV EATVGSQVRI PVKYLSYPAP 360
  361 DIKWYRNGRP IESNYTMIVG DELTIMEVSE RDAGNYTVIL TNPISMEKQS HMVSLVVNVP 420
  421 PQIGEKALIS PMDSYQYGTM QTLTCTVYAN PPLHHIQWYW QLEEACSYRP SQTNPYTCKE 480
  481 WRHVKDFQGG NKIEVTKNQY ALIEGKNKTV STLVIQAAYV SALYKCEAIN KAGRGERVIS 540
  541 FHVIRGPEIT VQPATQPTER ESMSLLCTAD RNTFENLTWY KLGSQATSVH MGESLTPVCK 600
  601 NLDALWKLNG TVFSNSTNDI LIVAFQNASL QDQGNYVCSA QDKKTKKRHC LVKQLVILER 660
  661 MAPMITGNLE NQTTTIGETI EVVCPTSGNP TPLITWFKDN ETLVEDSGIV LKDGNRNLTI 720
  721 RRVRKEDGGL YTCQACNVLG CARAETLFII EGVQEKTNLE VIILVGTAVI AMFFWLLLVI 780
  781 LVRTVKRANE GELKTGYLSI VMDPDELPLD ERCERLPYDA SKWEFPRDRL KLGKPLGRGA 840
  841 FGQVIEADAF GIDKTATCKT VAVKMLKEGA THSEHRALMS ELKILIHIGH HLNVVNLLGA 900
  901 CTKPGGPLMV IVEFCKFGNL STYLRGKRNE FVPYKSKGAR FRSGKDYVGE LSVDLKRRLD 960
  961 SITSSQSSAS SGFVEEKSLS DVEEEEASEE LYKDFLTLEH LICYSFQVAK GMEFLASRKC1020
 1021 IHRDLAARNI LLSEKNVVKI CDFGLARDIY KDPDYVRKGD PRLPLKWMAP ETIFDRIYTI1080
 1081 QSGVWSFGVL LWEIFSLGAS PYPGVKIDEK FCRRLKEGTR MRAPDYTTPE MYQTMLDCWH1140
 1141 EDPNQRPAFS ELVEHLGNLL QANAQQDGKD YIVLPMSETL SMEEDSGLSL PTSPVSCMEE1200
 1201 EEVCDPKFHY DNTAGISHYL QNSKRKSRPV SVKTFEDIPL EEPEVKVIPD DSQTDSGMVL1260
 1261 ASEELKTLED RNKLSPSFGG MMPSKSRESV ASEGSNQTSG YQSGYHSDDT DTTVYSSDEA1320
 1321 GLLKLVDVAG HVDSGTTLRS SPV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: VGFR2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: