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The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. An endothelium is an epithelium that lines an anatomical structure. The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. The process whereby a venous blood vessel endothelial cell acquires specialized features of a lymphatic vessel endothelial cell, a thin flattened cell that lines the inside surfaces of lymph vessels. The process whereby a relatively unspecialized cell acquires specialized features of a blood vessel endothelial cell, a thin flattened cell that lines the inside surfaces of blood vessels. The commitment of a cell to an endothelial cell fate and its capacity to differentiate into an endothelial cell. The progression of an endothelial cell over time, from its formation to the mature structure. The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers. The process whereby a mesodermal angioblast acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. Any process that activates or increases the frequency, rate or extent of endothelial cell differentiation. Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell differentiation. Any process that modulates the frequency, rate or extent of endothelial cell differentiation.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: endothelial cell differentiation
Acc: GO:0045446
Aspect: Biological Process
Desc: The process whereby a mesodermal angioblast acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.
Proteins in PDR annotated with:
   This term: 7 [Search]
   Term or descendants: 53 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045446 - endothelial cell differentiation (interactive image map)
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