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Protein Overview: IL4_RAT

General Information:
Name(s) found: IL4_RAT [Swiss-Prot]
Description(s) found:
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  • pir||ICRT4 interleukin-4 precursor - rat [NCBI NR]
  • gi|4894184|emb|CAA37256.2| interleukin 4 [Rattus norvegicus] [NCBI NR]
  • gi|42627877|ref|NP_958427.1| interleukin 4 [Rattus norvegicus] [NCBI NR]
  • gi|149052575|gb|EDM04392.1| interleukin 4, isoform CRA_c [Rattus norvegicus] [NCBI NR]
  • gi|124339|sp|P20096.2|IL4_RAT RecName: Full=Interleukin-4; Short=IL-4; AltName: Full=B-cell stimulatory factor 1; Short=BSF-1; AltName: Full=Lymphocyte stimulatory factor 1; AltName: Full=B-cell IGG differentiation factor; AltName: Full=B-cell growth fact [NCBI NR]
  • gi|11140161|emb|CAC16091.1| interleukin 4 [Rattus norvegicus] [NCBI NR]
  • Interleukin-4 OS=Rattus norvegicus GN=Il4 PE=2 SV=2 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):10-37563925 Interleukin-4 precursor [hmr_yeast5_DM3-1_pombe.fasta]
  • interleukin 4 [HMR_022704-rand.fasta]
  • interleukin 4 [Rattus norvegicus]gi|11140161|emb|CAC16091.1| interleukin 4 [Rattus norvegicus]gi|4894184|emb|CAA37256.2| interleukin 4 [Rattus norvegicus]gi|124339|sp|P20096|IL4_RAT Interleukin-4 precursor (IL-4) (B-cell stimulatory factor 1) (BSF-1) ( [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Interleukin-4 precursor [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Interleukin-4 precursor (IL-4) (B-cell stimulatory factor 1) (BSF-1) (Lymphocyte stimulatory factor 1) (B-cell IGG differentiation factor) (B-cell growth factor 1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • interleukin 4 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • interleukin 4, isoform CRA_c [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 INTERLEUKIN-4 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Il4 Interleukin-4 [rat-ipi-250309-contam.fasta]
  • Interleukin-4 OS=Rattus norvegicus GN=Il4 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 147 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [UNKNOWN][IDA]
    extracellular region [TAS]
    Biological Process: response to cytokine stimulus [IEP]
    positive regulation of cell proliferation [IDA]
    cholesterol metabolic process [IEA]
    B cell activation [IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    positive regulation of transcription factor activity [IEA]
    positive regulation of MHC class II biosynthetic process [UNKNOWN][IEA]
    response to ethanol [IEP]
    negative regulation of chronic inflammatory response [IDA]
    inflammatory response [NAS]
    positive regulation of gene-specific transcription [IDA]
    positive regulation of B cell activation [UNKNOWN]
    negative regulation of osteoclast differentiation [UNKNOWN][IEA]
    regulation of proton transport [IDA]
    positive regulation of peptidyl-tyrosine phosphorylation [UNKNOWN][IEA]
    regulation of immune response [UNKNOWN][IEA]
    female pregnancy [IEP]
    response to nutrient [IEP]
    positive regulation of isotype switching to IgG isotypes [UNKNOWN][IEA]
    response to organic cyclic substance [IEP]
    positive regulation of T cell proliferation [UNKNOWN]
    positive regulation of activated T cell proliferation [UNKNOWN][IEA]
    regulation of phosphorylation [UNKNOWN][IEA]
    positive regulation of tyrosine phosphorylation of Stat5 protein [UNKNOWN][IEA]
    negative regulation of acute inflammatory response [IDA]
    negative regulation of nitric oxide biosynthetic process [IDA]
    positive regulation of isotype switching to IgE isotypes [UNKNOWN][IEA]
    cellular response to mercury ion [IEP]
    response to drug [IEP]
    negative regulation of apoptosis [UNKNOWN][IEA]
    positive regulation of B cell proliferation [UNKNOWN][IEA]
    regulation of inflammatory response [IDA]
    positive regulation of interleukin-10 production [IDA]
    Molecular Function: growth factor activity [IEA]
    protein binding [UNKNOWN][IEA]
    cytokine activity [UNKNOWN][TAS]
    interleukin-4 receptor binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLSPHLAVT LFCFLICTGN GIHGCNDSPL REIINTLNQV TEKGTPCTEM FVPDVLTATR  60
   61 NTTENELICR ASRVLRKFYF PRDVPPCLKN KSGVLGELRK LCRGVSGLNS LRSCTVNEST 120
  121 LTTLKDFLES LKSILRGKYL QSCTSMS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] PSI-BLAST 44.69897 ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVESTIGATED BY SITE-DIRECTED MUTAGENESIS AND NMR SPECTROSCOPY

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytokine receptor binding
    		•  6.47223189691244 bayes_pls_golite062009
  • cytokine activity
    		•  6.38439864086716 bayes_pls_golite062009
  • receptor binding
    		•  5.3304255990112 bayes_pls_golite062009
  • growth factor activity
    		•  4.92105782010612 bayes_pls_golite062009
  • interleukin-10 receptor binding
    		•  3.27756723691542 bayes_pls_golite062009
  • protein binding
    		•  3.26483713001551 bayes_pls_golite062009
  • interleukin-4 receptor binding
    		•  3.17951022946458 bayes_pls_golite062009
  • growth hormone activity
    		•  2.71439518801599 bayes_pls_golite062009
  • binding
    		•  2.48265117231403 bayes_pls_golite062009
  • prolactin receptor binding
    		•  2.45721634350294 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  2.37535614986843 bayes_pls_golite062009
  • hormone activity
    		•  2.25587306265428 bayes_pls_golite062009
  • interleukin-12 binding
    		•  2.17594406686308 bayes_pls_golite062009
  • interleukin-27 binding
    		•  1.83998174953013 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  1.79326213321183 bayes_pls_golite062009
  • interleukin-2 receptor binding
    		•  1.24568403220915 bayes_pls_golite062009
  • interleukin-12 beta subunit binding
    		•  1.10825259714222 bayes_pls_golite062009
  • erythropoietin receptor binding
    		•  0.77580300541347 bayes_pls_golite062009
  • interleukin-3 receptor binding
    		•  0.264629367313661 bayes_pls_golite062009
  • catalytic activity
    		•  0.246169290135575 bayes_pls_golite062009
  • interleukin-12 receptor binding
    		•  0.218984052557791 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.010318258615897 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle