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View Structure Prediction Details

Protein: IL4_RAT
Organism: Rattus norvegicus
Length: 147 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IL4_RAT.

Description E-value Query
Range
Subject
Range
gi|50296664 - gi|50296664|gb|AAT73594.1| mIL4-SWM-S9-SWM precursor [synthetic construct]
207.0 [0..1] [145..1]
gi|90992738 - gi|90992738|gb|ABE03016.1| interleukin-4 [Peromyscus maniculatus]
202.0 [0..1] [145..1]
gi|55624750, gi|... - ref|XP_517924.1| PREDICTED: similar to interleukin 4 [Pan troglodytes], gi|39980475|gb|AAR32990.1| ...
202.0 [0..1] [144..1]
gi|61358436, gi|... - gi|61358436|gb|AAX41567.1| interleukin 4 [synthetic construct], gi|60816923|gb|AAX36402.1| interleuk...
IL4_PANTR - Interleukin-4 OS=Pan troglodytes GN=IL4 PE=2 SV=2
HGNC:6014|MIM:14... - 4
IL4 - interleukin 4
200.0 [0..1] [144..1]
gi|20530679 - gi|20530679|gb|AAM27191.1|AF493991_1 interleukin-4 precursor [Sus scrofa]
200.0 [0..1] [142..1]
gi|16417607 - gi|16417607|gb|AAL18820.1|AF421390_1 interleukin 4 precursor [Sigmodon hispidus]
199.0 [0..1] [146..1]
gi|57157562 - gi|57157562|dbj|BAD83771.1| interleukin 4 [Mus musculus molossinus]
198.0 [0..1] [141..1]

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Predicted Domain #1
Region A:
Residues: [1-147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLSPHLAVT LFCFLICTGN GIHGCNDSPL REIINTLNQV TEKGTPCTEM FVPDVLTATR  60
   61 NTTENELICR ASRVLRKFYF PRDVPPCLKN KSGVLGELRK LCRGVSGLNS LRSCTVNEST 120
  121 LTTLKDFLES LKSILRGKYL QSCTSMS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.69897
Match: 1cylA
Description: ASPECTS OF RECEPTOR BINDING AND SIGNALLING OF INTERLEUKIN-4 INVESTIGATED BY SITE-DIRECTED MUTAGENESIS AND NMR SPECTROSCOPY
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytokine receptor binding 6.47223189691244 bayes_pls_golite062009
cytokine activity 6.38439864086716 bayes_pls_golite062009
receptor binding 5.3304255990112 bayes_pls_golite062009
growth factor activity 4.92105782010612 bayes_pls_golite062009
interleukin-10 receptor binding 3.27756723691542 bayes_pls_golite062009
protein binding 3.26483713001551 bayes_pls_golite062009
interleukin-4 receptor binding 3.17951022946458 bayes_pls_golite062009
growth hormone activity 2.71439518801599 bayes_pls_golite062009
binding 2.48265117231403 bayes_pls_golite062009
prolactin receptor binding 2.45721634350294 bayes_pls_golite062009
interleukin-6 receptor binding 2.37535614986843 bayes_pls_golite062009
hormone activity 2.25587306265428 bayes_pls_golite062009
interleukin-12 binding 2.17594406686308 bayes_pls_golite062009
interleukin-27 binding 1.83998174953013 bayes_pls_golite062009
ciliary neurotrophic factor receptor binding 1.79326213321183 bayes_pls_golite062009
interleukin-2 receptor binding 1.24568403220915 bayes_pls_golite062009
interleukin-12 beta subunit binding 1.10825259714222 bayes_pls_golite062009
erythropoietin receptor binding 0.77580300541347 bayes_pls_golite062009
interleukin-3 receptor binding 0.264629367313661 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009
interleukin-12 receptor binding 0.218984052557791 bayes_pls_golite062009
transcription regulator activity 0.010318258615897 bayes_pls_golite062009

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