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Protein Overview: THA_RAT

General Information:
Name(s) found: THA_RAT [Swiss-Prot]
Description(s) found:
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  • gi|52001262|sp|P63059.1|THA_RAT RecName: Full=Thyroid hormone receptor alpha; AltName: Full=Nuclear receptor subfamily 1 group A member 1; AltName: Full=C-erbA-alpha; AltName: Full=c-erbA-1 [NCBI NR]
  • Thyroid hormone receptor alpha OS=Rattus norvegicus GN=Thra PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):10-85912202 Splice isoform Alpha-2 of P15827 [hmr_yeast5_DM3-1_pombe.fasta]
  • Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1)gi|52001262|sp|P63059|THA_RAT Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Splice Isoform Alpha-2 of Thyroid hormone receptor alpha [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Thyroid hormone receptor alpha (Nuclear receptor subfamily 1 group A member 1) (C-erbA-alpha) (c-erbA-1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SPLICE ISOFORM 1 OF THYROID HORMONE RECEPTOR ALPHA [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Thra Isoform Alpha-2 of Thyroid hormone receptor alpha [rat-ipi-250309-contam.fasta]
  • Isoform Alpha-2 of Thyroid hormone receptor alpha OS=Rattus norvegicus GN=Thra [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    cytoplasm [UNKNOWN][IDA]
    mitochondrion [IDA]
    cytosol [IDA]
    Biological Process: positive regulation of female receptivity [UNKNOWN]
    cytoplasmic sequestering of transcription factor [UNKNOWN]
    positive regulation of transcription from RNA polymerase II promoter [IDA]
    learning or memory [UNKNOWN]
    hormone-mediated signaling pathway [UNKNOWN]
    response to cold [UNKNOWN]
    regulation of lipid catabolic process [UNKNOWN]
    cartilage condensation [UNKNOWN]
    ossification [UNKNOWN]
    kidney development [IEP]
    gut development [IEP]
    liver development [IEP]
    positive regulation of myotube differentiation [UNKNOWN]
    regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN]
    adrenal gland development [IEP]
    lung development [IEP]
    female courtship behavior [UNKNOWN]
    regulation of myeloid cell apoptosis [UNKNOWN]
    regulation of heart contraction [UNKNOWN]
    negative regulation of transcription factor activity [IDA]
    embryonic organ development [IEP]
    brain development [IEP]
    regulation of thyroid hormone mediated signaling pathway [UNKNOWN]
    response to stress [IEP]
    organ morphogenesis [UNKNOWN]
    erythrocyte differentiation [UNKNOWN]
    thyroid gland development [UNKNOWN]
    negative regulation of transcription [UNKNOWN]
    response to drug [IEP]
    response to nutrient levels [IEP]
    Molecular Function: protein homodimerization activity [IDA]
    sequence-specific DNA binding [IDA]
    steroid receptor RNA activator RNA binding [UNKNOWN]
    intronic regulatory region binding [IDA]
    thyroid hormone receptor activity [UNKNOWN][IDA]
    [NOT]DNA binding [UNKNOWN]
    transcription factor activity [UNKNOWN]
    protein binding [UNKNOWN]
    ligand-dependent nuclear receptor activity [UNKNOWN]
    transcription regulator activity [UNKNOWN]
    protein heterodimerization activity [IDA]
    single-stranded RNA binding [UNKNOWN][IDA]
    thyroid hormone binding [UNKNOWN]
    promoter binding [UNKNOWN]
    transcription activator activity [IDA]
    transcription repressor activity [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQKPSKVEC GSDPEENSAR SPDGKRKRKN GQCPLKSSMS GYIPSYLDKD EQCVVCGDKA  60
   61 TGYHYRCITC EGCKGFFRRT IQKNLHPTYS CKYDSCCVID KITRNQCQLC RFKKCIAVGM 120
  121 AMDLVLDDSK RVAKRKLIEQ NRERRRKEEM IRSLQQRPEP TPEEWDLIHV ATEAHRSTNA 180
  181 QGSHWKQRRK FLPDDIGQSP IVSMPDGDKV DLEAFSEFTK IITPAITRVV DFAKKLPMFS 240
  241 ELPCEDQIIL LKGCCMEIMS LRAAVRYDPE SDTLTLSGEM AVKREQLKNG GLGVVSDAIF 300
  301 ELGKSLSAFN LDDTEVALLQ AVLLMSTDRS GLLCVDKIEK SQEAYLLAFE HYVNHRKHNI 360
  361 PHFWPKLLMK EREVQSSILY KGAAAEGRPG GSLGVHPEGQ QLLGMHVVQG PQVRQLEQQF 420
  421 GEAGSLRGPV LQHQSPKSPQ QRLLELLHRS GILHSRAVCG EDDSSEASSL SSSSSDEDTE 480
  481 VFEDLAGKAA SP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle