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Protein Overview: MIF_RAT

General Information:
Name(s) found: MIF_RAT [Swiss-Prot]
Description(s) found:
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  • gi|38181546|gb|AAH61545.1| Macrophage migration inhibitory factor [Rattus norvegicus] [NCBI NR]
  • gi|149043727|gb|EDL97178.1| rCG60731, isoform CRA_c [Rattus norvegicus] [NCBI NR]
  • gi|1432169|gb|AAB04024.1| macrophage migration inhibitory factor [NCBI NR]
  • gi|13591985|ref|NP_112313.1| macrophage migration inhibitory factor [Rattus norvegicus] [NCBI NR]
  • gi|1170956|sp|P30904.4|MIF_RAT RecName: Full=Macrophage migration inhibitory factor; Short=MIF; AltName: Full=Phenylpyruvate tautomerase; AltName: Full=L-dopachrome tautomerase; AltName: Full=L-dopachrome isomerase; AltName: Full=Glutathione-binding 13 kD [NCBI NR]
  • Macrophage migration inhibitory factor OS=Rattus norvegicus GN=Mif PE=1 SV=4 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):1-73691124 macrophage migration inhibitory factor [hmr_yeast5_DM3-1_pombe.fasta]
  • macrophage migration inhibitory factor [HMR_022704-rand.fasta]
  • Macrophage migration inhibitory factor [Rattus norvegicus]gi|13591985|ref|NP_112313.1| macrophage migration inhibitory factor [Rattus norvegicus]gi|7514124|pir||I52370 macrophage migration inhibitory factor MIF [similarity] - ratgi|663140|gb|AAB32392.1 [nrdb_11152004_Chlamydomonas]
  • (NM_031051) macrophage migration inhibitory factor [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Macrophage migration inhibitory factor (MIF) (Phenylpyruvate tautomerase) (Glutathione-binding 13 kDa protein) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • macrophage migration inhibitory factor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • rCG60731, isoform CRA_c [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Macrophage migration inhibitory factor [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 MACROPHAGE MIGRATION INHIBITORY FACTOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Mif Macrophage migration inhibitory factor [rat-ipi-250309-contam.fasta]
  • Macrophage migration inhibitory factor OS=Rattus norvegicus GN=Mif [011711_HMR.fasta]
  • Isoform of P30904, Macrophage migration inhibitory factor OS=Rattus norvegicus GN=Mif PE=1 SV=1 [RAT.fasta.20160308]
    • Organism: Rattus norvegicus
    Length: 115 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA]
    extracellular space [IDA]
    cytoplasm [IDA]
    extracellular region [UNKNOWN][IEA]
    cell surface [UNKNOWN]
    Biological Process: cell proliferation [UNKNOWN]
    drinking behavior [IMP]
    response to menaquinone [IEP]
    response to progesterone stimulus [IEP]
    positive regulation of potassium ion transport [IMP]
    skin development [IEP]
    positive regulation of glycolysis [IMP]
    response to mechanical stimulus [IEP]
    positive regulation of acute inflammatory response [IMP]
    positive regulation of protein kinase A signaling cascade [UNKNOWN]
    inflammatory response [IEA]
    response to heat [IEP]
    wound healing [IEP]
    response to insulin stimulus [IEP]
    positive regulation of axon regeneration [IMP]
    hair follicle development [IEP]
    negative regulation of cell cycle arrest [UNKNOWN]
    positive regulation of fibroblast proliferation [UNKNOWN]
    response to glucocorticoid stimulus [IEP]
    positive regulation of cytokine secretion [UNKNOWN]
    response to inorganic substance [IEP]
    protein homotrimerization [UNKNOWN]
    positive regulation of immune response [IMP]
    positive regulation of peptidyl-tyrosine phosphorylation [UNKNOWN]
    positive regulation of peptidyl-serine phosphorylation [UNKNOWN]
    positive regulation of phosphorylation [UNKNOWN]
    negative regulation of DNA damage response, signal transduction by p53 class mediator [UNKNOWN]
    spermatogenesis [IMP]
    response to vitamin E [IEP]
    positive regulation of glucose import [IMP]
    cell surface receptor linked signaling pathway [UNKNOWN]
    brain development [IEP]
    aging [IEP]
    response to hormone stimulus [IEP]
    cell aging [UNKNOWN]
    brain renin-angiotensin system [IMP]
    regulation of cell proliferation [UNKNOWN]
    negative regulation of gene expression [UNKNOWN]
    response to drug [IEP]
    negative regulation of apoptosis [UNKNOWN]
    innate immune response [IEA]
    prostaglandin biosynthetic process [UNKNOWN]
    positive regulation of ERK1 and ERK2 cascade [UNKNOWN]
    DNA damage response, signal transduction by p53 class mediator [UNKNOWN]
    response to estradiol stimulus [IEP]
    positive regulation of B cell proliferation [UNKNOWN]
    response to lipopolysaccharide [IEP]
    carboxylic acid metabolic process [UNKNOWN]
    Molecular Function: phenylpyruvate tautomerase activity [UNKNOWN][IEA]
    protein binding [UNKNOWN]
    chemoattractant activity [UNKNOWN]
    cell surface binding [UNKNOWN]
    cytokine activity [UNKNOWN][IEA]
    protein complex binding [IDA]
    dopachrome isomerase activity [UNKNOWN][ISS]
    receptor binding [UNKNOWN]
    cytokine receptor binding [UNKNOWN]
    isomerase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPMFIVNTNV PRASVPEGFL SELTQQLAQA TGKPAQYIAV HVVPDQLMTF SGTSDPCALC  60
   61 SLHSIGKIGG AQNRNYSKLL CGLLSDRLHI SPDRVYINYY DMNAANVGWN GSTFA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..115] PSI-BLAST 47.045757 Microphage migration inhibition factor (MIF)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phenylpyruvate tautomerase activity
    		•  3.84932786282501 bayes_pls_golite062009
  • cytokine activity
    		•  2.80410252537768 bayes_pls_golite062009
  • intramolecular oxidoreductase activity
    		•  2.17252244354636 bayes_pls_golite062009
  • binding
    		•  1.9717928129965 bayes_pls_golite062009
  • receptor binding
    		•  1.79096938850925 bayes_pls_golite062009
  • protein binding
    		•  1.70051621352839 bayes_pls_golite062009
  • catalytic activity
    		•  0.836951613125537 bayes_pls_golite062009
  • isomerase activity
    		•  0.804529932513639 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing C=C bonds
    		•  0.452407074010503 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle