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Protein Overview: IL6_MOUSE

General Information:
Name(s) found: IL6_MOUSE [Swiss-Prot]
Description(s) found:
Found 36 descriptions.
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  • Interleukin-6 OS=Mus musculus GN=Il6 PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 211 amino acids

    Gene Ontology:
    Cellular Component: extracellular space [UNKNOWN][IDA]
    external side of plasma membrane [IDA]
    extracellular region [IEA]
    Biological Process: regulation of cell shape [UNKNOWN]
    neuroprotection [UNKNOWN]
    positive regulation of nitric oxide biosynthetic process [UNKNOWN]
    positive regulation of protein import into nucleus, translocation [UNKNOWN]
    muscle cell homeostasis [IGI]
    negative regulation of cell proliferation [UNKNOWN]
    positive regulation of neuron differentiation [UNKNOWN]
    negative regulation of gluconeogenesis [UNKNOWN]
    negative regulation of muscle organ development [UNKNOWN]
    positive regulation of DNA replication [UNKNOWN]
    epithelial cell proliferation involved in salivary gland morphogenesis [IDA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    negative regulation of protein kinase activity [UNKNOWN]
    branching involved in salivary gland morphogenesis [IDA][IMP]
    defense response to protozoan [IMP]
    glucagon secretion [IMP]
    immune response [IEA]
    positive regulation of transcription, DNA-dependent [IDA]
    negative regulation of chemokine biosynthetic process [IDA][IMP]
    negative regulation of caspase activity [UNKNOWN]
    interleukin-6-mediated signaling pathway [IDA]
    endocrine pancreas development [IMP]
    positive regulation of epithelial cell proliferation [IDA][IMP]
    positive regulation of peptidyl-tyrosine phosphorylation [UNKNOWN]
    negative regulation of cytokine secretion [UNKNOWN]
    positive regulation of peptidyl-serine phosphorylation [UNKNOWN]
    positive regulation of T-helper 2 cell differentiation [IDA]
    cell redox homeostasis [UNKNOWN]
    regulation of apoptosis [IMP]
    positive regulation of MAPKKK cascade [UNKNOWN]
    acute-phase response [IEA]
    neutrophil apoptosis [IDA][IMP]
    regulation of cell proliferation [IGI]
    negative regulation of hormone secretion [IDA]
    positive regulation of JAK-STAT cascade [UNKNOWN]
    positive regulation of transmission of nerve impulse [UNKNOWN]
    regulation of circadian sleep/wake cycle, non-REM sleep [UNKNOWN]
    positive regulation of gene expression [UNKNOWN]
    positive regulation of ERK1 and ERK2 cascade [UNKNOWN]
    Molecular Function: growth factor activity [IEA]
    protein binding [IPI]
    cytokine activity [UNKNOWN][IDA]
    receptor binding [UNKNOWN]
    interleukin-6 receptor binding [UNKNOWN][IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFLSARDFH PVAFLGLMLV TTTAFPTSQV RRGDFTEDTT PNRPVYTTSQ VGGLITHVLW  60
   61 EIVEMRKELC NGNSDCMNND DALAENNLKL PEIQRNDGCY QTGYNQEICL LKISSGLLEY 120
  121 HSYLEYMKNN LKDNKKDKAR VLQRDTETLI HIFNQEVKDL HKIVLPTPIS NALLTDKLES 180
  181 QKEWLRTKTI QFILKSLEEF LKVTLRSTRQ T

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..211] PSI-BLAST 70.154902 Interleukin-6

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ciliary neurotrophic factor receptor binding
    		•  7.71327321994954 bayes_pls_golite062009
  • cytokine receptor binding
    		•  6.47223189691244 bayes_pls_golite062009
  • cytokine activity
    		•  6.38439864086716 bayes_pls_golite062009
  • receptor binding
    		•  5.3304255990112 bayes_pls_golite062009
  • growth factor activity
    		•  4.92105782010612 bayes_pls_golite062009
  • protein binding
    		•  3.52041127390038 bayes_pls_golite062009
  • interleukin-10 receptor binding
    		•  3.48926618931264 bayes_pls_golite062009
  • macrophage colony stimulating factor receptor binding
    		•  3.36453321177911 bayes_pls_golite062009
  • binding
    		•  2.74412602806415 bayes_pls_golite062009
  • growth hormone activity
    		•  2.60130826123596 bayes_pls_golite062009
  • hormone activity
    		•  2.52921243340076 bayes_pls_golite062009
  • prolactin receptor binding
    		•  2.45721634350294 bayes_pls_golite062009
  • interleukin-6 receptor binding
    		•  2.37535614986843 bayes_pls_golite062009
  • interferon-alpha/beta receptor binding
    		•  2.26198409097082 bayes_pls_golite062009
  • interleukin-12 binding
    		•  2.17594406686308 bayes_pls_golite062009
  • erythropoietin receptor binding
    		•  1.76853668185022 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.52819399447638 bayes_pls_golite062009
  • signal transducer activity
    		•  1.52819399447638 bayes_pls_golite062009
  • oncostatin-M receptor binding
    		•  1.33490991236904 bayes_pls_golite062009
  • interleukin-2 receptor binding
    		•  1.24568403220915 bayes_pls_golite062009
  • interleukin-12 beta subunit binding
    		•  1.10825259714222 bayes_pls_golite062009
  • interleukin-5 receptor binding
    		•  0.89757450102906 bayes_pls_golite062009
  • interleukin-27 binding
    		•  0.83689047148519 bayes_pls_golite062009
  • cytokine binding
    		•  0.75738898750854 bayes_pls_golite062009
  • catalytic activity
    		•  0.246169290135575 bayes_pls_golite062009
  • interleukin-12 receptor binding
    		•  0.218984052557791 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0451597942796057 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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