General Information: |
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Name(s) found: |
IL6_MOUSE
[Swiss-Prot]
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Description(s) found:
SHOW ONLY BEST |
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Organism: | Mus musculus |
Length: | 211 amino acids |
Gene Ontology: |
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Cellular Component: |
extracellular space
[UNKNOWN][IDA]
external side of plasma membrane [IDA] extracellular region [IEA] |
Biological Process: |
regulation of cell shape
[UNKNOWN]
neuroprotection [UNKNOWN] positive regulation of nitric oxide biosynthetic process [UNKNOWN] positive regulation of protein import into nucleus, translocation [UNKNOWN] muscle cell homeostasis [IGI] negative regulation of cell proliferation [UNKNOWN] positive regulation of neuron differentiation [UNKNOWN] negative regulation of gluconeogenesis [UNKNOWN] negative regulation of muscle organ development [UNKNOWN] positive regulation of DNA replication [UNKNOWN] epithelial cell proliferation involved in salivary gland morphogenesis [IDA] positive regulation of transcription from RNA polymerase II promoter [UNKNOWN] negative regulation of protein kinase activity [UNKNOWN] branching involved in salivary gland morphogenesis [IDA][IMP] defense response to protozoan [IMP] glucagon secretion [IMP] immune response [IEA] positive regulation of transcription, DNA-dependent [IDA] negative regulation of chemokine biosynthetic process [IDA][IMP] negative regulation of caspase activity [UNKNOWN] interleukin-6-mediated signaling pathway [IDA] endocrine pancreas development [IMP] positive regulation of epithelial cell proliferation [IDA][IMP] positive regulation of peptidyl-tyrosine phosphorylation [UNKNOWN] negative regulation of cytokine secretion [UNKNOWN] positive regulation of peptidyl-serine phosphorylation [UNKNOWN] positive regulation of T-helper 2 cell differentiation [IDA] cell redox homeostasis [UNKNOWN] regulation of apoptosis [IMP] positive regulation of MAPKKK cascade [UNKNOWN] acute-phase response [IEA] neutrophil apoptosis [IDA][IMP] regulation of cell proliferation [IGI] negative regulation of hormone secretion [IDA] positive regulation of JAK-STAT cascade [UNKNOWN] positive regulation of transmission of nerve impulse [UNKNOWN] regulation of circadian sleep/wake cycle, non-REM sleep [UNKNOWN] positive regulation of gene expression [UNKNOWN] positive regulation of ERK1 and ERK2 cascade [UNKNOWN] |
Molecular Function: |
growth factor activity
[IEA]
protein binding [IPI] cytokine activity [UNKNOWN][IDA] receptor binding [UNKNOWN] interleukin-6 receptor binding [UNKNOWN][IDA] |
Sequence: |
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Sequence: [PDR BLAST] [ProtParam] |
1 11 21 31 41 51 | | | | | | 1 MKFLSARDFH PVAFLGLMLV TTTAFPTSQV RRGDFTEDTT PNRPVYTTSQ VGGLITHVLW 60 61 EIVEMRKELC NGNSDCMNND DALAENNLKL PEIQRNDGCY QTGYNQEICL LKISSGLLEY 120 121 HSYLEYMKNN LKDNKKDKAR VLQRDTETLI HIFNQEVKDL HKIVLPTPIS NALLTDKLES 180 181 QKEWLRTKTI QFILKSLEEF LKVTLRSTRQ T |
NOT SHOWING SINGLE HITS. [ Show Single Hits ]
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Domains predicted:
# | Region(s) | Method | Confidence | Match Description | |
1 | View Details | [1..211] | 70.154902 | Interleukin-6 |
Functions predicted (by domain):
# | Gene Ontology predictions | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 |
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Source: Reynolds et al. 2008. Manuscript submitted |