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View Structure Prediction Details

Protein: IL6_MOUSE
Organism: Mus musculus
Length: 211 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IL6_MOUSE.

Description E-value Query
Range
Subject
Range
gi|2136608 - pir||I46621 prointerleukin 6 - pig
gi|164625, gi|11... - gi|47523852|ref|NP_999564.1| interleukin 6 [Sus scrofa], gi|198033679|emb|CAM58482.1| interleukin 6 ...
324.0 [0..1] [209..1]
IL6_CAMBA - Interleukin-6 OS=Camelus bactrianus GN=IL6 PE=2 SV=1
318.0 [0..1] [209..1]
IL6_DELLE - Interleukin-6 OS=Delphinapterus leucas GN=IL6 PE=2 SV=1
317.0 [0..1] [209..1]
IL6_LAMGL - Interleukin-6 OS=Lama glama GN=IL6 PE=2 SV=1
314.0 [0..1] [209..1]
IL6_ORCOR - Interleukin-6 (Fragment) OS=Orcinus orca GN=IL6 PE=2 SV=1
309.0 [0..5] [209..2]
gi|46561780 - gi|46561780|gb|AAT01105.1| rpL23-mIL-6 fusion protein [rpL23-fusion expression vector pmIL-6]
307.0 [0..2] [211..114]
gi|9247084 - gi|9247084|gb|AAF86275.1| interleukin-6 [Canis familiaris]
305.0 [0..1] [209..1]

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Predicted Domain #1
Region A:
Residues: [1-211]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFLSARDFH PVAFLGLMLV TTTAFPTSQV RRGDFTEDTT PNRPVYTTSQ VGGLITHVLW  60
   61 EIVEMRKELC NGNSDCMNND DALAENNLKL PEIQRNDGCY QTGYNQEICL LKISSGLLEY 120
  121 HSYLEYMKNN LKDNKKDKAR VLQRDTETLI HIFNQEVKDL HKIVLPTPIS NALLTDKLES 180
  181 QKEWLRTKTI QFILKSLEEF LKVTLRSTRQ T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 70.154902
Match: 1p9mB
Description: Interleukin-6
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ciliary neurotrophic factor receptor binding 7.71327321994954 bayes_pls_golite062009
cytokine receptor binding 6.47223189691244 bayes_pls_golite062009
cytokine activity 6.38439864086716 bayes_pls_golite062009
receptor binding 5.3304255990112 bayes_pls_golite062009
growth factor activity 4.92105782010612 bayes_pls_golite062009
protein binding 3.52041127390038 bayes_pls_golite062009
interleukin-10 receptor binding 3.48926618931264 bayes_pls_golite062009
macrophage colony stimulating factor receptor binding 3.36453321177911 bayes_pls_golite062009
binding 2.74412602806415 bayes_pls_golite062009
growth hormone activity 2.60130826123596 bayes_pls_golite062009
hormone activity 2.52921243340076 bayes_pls_golite062009
prolactin receptor binding 2.45721634350294 bayes_pls_golite062009
interleukin-6 receptor binding 2.37535614986843 bayes_pls_golite062009
interferon-alpha/beta receptor binding 2.26198409097082 bayes_pls_golite062009
interleukin-12 binding 2.17594406686308 bayes_pls_golite062009
erythropoietin receptor binding 1.76853668185022 bayes_pls_golite062009
molecular transducer activity 1.52819399447638 bayes_pls_golite062009
signal transducer activity 1.52819399447638 bayes_pls_golite062009
oncostatin-M receptor binding 1.33490991236904 bayes_pls_golite062009
interleukin-2 receptor binding 1.24568403220915 bayes_pls_golite062009
interleukin-12 beta subunit binding 1.10825259714222 bayes_pls_golite062009
interleukin-5 receptor binding 0.89757450102906 bayes_pls_golite062009
interleukin-27 binding 0.83689047148519 bayes_pls_golite062009
cytokine binding 0.75738898750854 bayes_pls_golite062009
catalytic activity 0.246169290135575 bayes_pls_golite062009
interleukin-12 receptor binding 0.218984052557791 bayes_pls_golite062009
transcription repressor activity 0.0451597942796057 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle