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Protein Overview: alh-6

General Information:
Name(s) found: alh-6 / CE40074 [WormBase]
Description(s) found:
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  • WBGene00000112 locus:alh-6 status:Confirmed UniProt:G4RZC3 protein_id:CCD64344.1 [WormBase]
  • gi|115532534|ref|NP_001040782.1| ALdehyde deHydrogenase family member (alh-6) [Caenorhabditis elegans] [NCBI NR]
  • CE40074 WBGene00000112 locus:alh-6 status:Confirmed [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE40074 WBGene00000112 locus:alh-6 status:Confirmed| [wormORF-contam.fasta]
  • CE40074 WBGene00000112 locus:alh-6 status:Confirmed [wormpep160-contam.fasta]
  • ALdehyde deHydrogenase family member (alh-6) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE40074 WBGene00000112 locus:alh-6 status:Confirmed UniProt:G4RZC3 protein_id:CCD64344.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE40074 WBGene00000112 locus:alh-6 status:Confirmed UniProt:G4RZC3 protein_id:CCD64344.1 Aldehyde dehydrogenase [wormpep246-ecoli-contam.fasta]
  • Isoform of G5EC31, ALdehyde deHydrogenase OS=Caenorhabditis elegans GN=alh-6 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 423 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IEALink to PubMed article]
    Biological Process: cellular aldehyde metabolic process [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    proline metabolic process [IEALink to PubMed article]
    negative regulation of transcription [IEALink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    metabolic process [IEALink to PubMed article]
    proline biosynthetic process [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    valine metabolic process [IEALink to PubMed article]
    betaine biosynthetic process [IEALink to PubMed article]
    positive regulation of locomotion [IMPLink to PubMed article]
    Molecular Function: 1-pyrroline-5-carboxylate dehydrogenase activity [IEALink to PubMed article]
    DNA binding [IEALink to PubMed article]
    betaine-aldehyde dehydrogenase activity [IEALink to PubMed article]
    proline dehydrogenase activity [IEALink to PubMed article]
    oxidoreductase activity [IEALink to PubMed article]
    aldehyde dehydrogenase [NAD(P)+] activity [IEALink to PubMed article]
    methylmalonate-semialdehyde dehydrogenase (acylating) activity [IEALink to PubMed article]
    transcription repressor activity [IEALink to PubMed article]
    oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLNASTMLG QGKNIIQAEI DAACELIDFF RFNAVFAMEL EHYEPISTKI TKNTMQFRGM  60
   61 EGFVAAIAPF NFTAIGGNLP TAPALMGNVS LWKPSNTAVL SNYIIYELLE EAGMPPGILS 120
  121 FLPSDGPVFG DVITASPHLS AVNFTGSVPT FKTIWRKVAE NLDNYVTFPK LIGECGGKNF 180
  181 HFVHPSAHVD AVAAGTARSA WEYSGQKCSA CSRMYAPKSI WPKILEKISA IHKEIKLGDV 240
  241 RDGSVFLSAV IDDKAFARLK AYIDFAKTGA DGANVVLGGK CDDKTGYFIE PTLITVTDPK 300
  301 SKLLTEEMFG PVVTVLVYED SKVDEVLATV KDATPYGLTG AVFSQDKEFL YRARDVLRDA 360
  361 VGNMYLNDKS TGSIVGQQPF GGSRLSGTND KAGGPHYGLR WTSPLTIKET SVSLTDWKYP 420
  421 SME

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..423] PSI-BLAST 102.0 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  4.47226217021998 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  4.34495776828926 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase [NAD(P)+] activity
    		•  3.64672165191647 bayes_pls_golite062009
  • 3-chloroallyl aldehyde dehydrogenase activity
    		•  3.37049090049734 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
    		•  3.2867555127991 bayes_pls_golite062009
  • catalytic activity
    		•  2.80804701752928 bayes_pls_golite062009
  • succinate-semialdehyde dehydrogenase activity
    		•  2.71501590413507 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  2.6673036327943 bayes_pls_golite062009
  • aldehyde dehydrogenase (NAD) activity
    		•  2.26056590784818 bayes_pls_golite062009
  • methylmalonate-semialdehyde dehydrogenase (acylating) activity
    		•  1.59279206536309 bayes_pls_golite062009
  • glutamate-5-semialdehyde dehydrogenase activity
    		•  0.882678635212924 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.65

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle