Protein Overview: NKX25_MOUSE

General Information:
Name(s) found:	NKX25_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|74209095\|dbj\|BAE24947.1\| unnamed protein product [Mus musculus] [NCBI NR] gi\|6679068\|ref\|NP_032726.1\| NK2 transcription factor related, locus 5 [Mus musculus] [NCBI NR] gi\|4050016\|gb\|AAC97934.1\| homeobox protein NKX-2.5 [Mus musculus] [NCBI NR] gi\|2706485\|emb\|CAA53169.1\| homeobox [Mus musculus] [NCBI NR] gi\|223460430\|gb\|AAI39300.1\| NK2 transcription factor related, locus 5 (Drosophila) [Mus musculus] [NCBI NR] gi\|223460028\|gb\|AAI39304.1\| NK2 transcription factor related, locus 5 (Drosophila) [Mus musculus] [NCBI NR] gi\|148690570\|gb\|EDL22517.1\| NK2 transcription factor related, locus 5 (Drosophila) [Mus musculus] [NCBI NR] gi\|1170294\|sp\|P42582.1\|NKX25_MOUSE RecName: Full=Homeobox protein Nkx-2.5; AltName: Full=Homeobox protein NK-2 homolog E; AltName: Full=Cardiac-specific homeobox; AltName: Full=Homeobox protein CSX [NCBI NR] Homeobox protein Nkx-2.5 OS=Mus musculus GN=Nkx2-5 PE=1 SV=1 [Swiss-Prot] (P42582) Homeobox protein Nkx-2.5 (Homeobox protein NK-2 homolog E) (Cardiac-specific homeobox) (Homeobox protein CSX) [Swiss-Prot] Ensembl_locations(Chr-bp):17-25533337 Homeobox protein Nkx-2.5 [hmr_yeast5_DM3-1_pombe.fasta] NK2 transcription factor related, locus 5; Drosophila NK2 transcription factor related, locus 5 [HMR_022704-rand.fasta] Homeobox protein Nkx-2.5 [ipi.MOUSE.v3.06.fasta] NK2 transcription factor related, locus 5 [Mus musculus]gi\|1170294\|sp\|P42582\|NK25_MOUSE Homeobox protein Nkx-2.5 (Homeobox protein NK-2 homolog E) (Cardiac-specific homeobox) (Homeobox protein CSX)gi\|4050016\|gb\|AAC97934.1\| homeobox protein NKX-2.5 [Mus [nrdb_11152004_Chlamydomonas] Tax_Id=10090 Homeobox protein Nkx-2.5 [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] (NM_008700) NK2 transcription factor related, locus 5; Drosophila NK2 transcription factor related, locus 5 [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] NK2 transcription factor related, locus 5 [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] Homeobox protein Nkx-2.5 (Homeobox protein NK-2 homolog E) (Cardiac-specific homeobox) (Homeobox protein CSX) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] NK2 transcription factor related, locus 5 (Drosophila) [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] unnamed protein product [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] homeobox [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] homeobox protein NKX-2.5 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 HOMEOBOX PROTEIN NKX-2.5 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Nkx2-5 Homeobox protein Nkx-2.5 [mouse-ipi-250309-contam.fasta] Tax_Id=10090 Gene_Symbol=Nkx2-5 Homeobox protein Nkx-2.5 ENSMUSG00000015579 IPI00117496 [IPIxENS.MOUSE_plus_REVERSE.fasta] homeobox protein Nkx-2.5 [Mus musculus] [NCBI-RefSeq_mouse_na_05-17-2010_reversed.fasta] IPI:IPI00117496.1\|SWISS-PROT:P42582\|TREMBL:Q3UQU2;Q925V3\|ENSEMBL:ENSMUSP00000015723\|REFSEQ:NP_032726 Tax_Id=10090 Gene_Symbol=Nkx2-5 Homeobox protein Nkx-2.5 [ipi.MOUSE.fasta.20090209] Homeobox protein Nkx-2.5 OS=Mus musculus GN=Nkx2-5 [011711_HMR.fasta] sp\|P42582\|NKX25_MOUSE Homeobox protein Nkx-2.5 OS=Mus musculus GN=Nkx2-5 PE=1 SV=1 [uniprot.sptr.mouse.20130102] tr\|Q3UQU2\|Q3UQU2_MOUSE NK2 transcription factor related, locus 5 (Drosophila) OS=Mus musculus GN=Nkx2-5 PE=2 SV=1 [uniprot.sptr.mouse.20130102] NK2 transcription factor related, locus 5 (Drosophila) OS=Mus musculus GN=Nkx2-5 PE=2 SV=1 [mouse-uniprot-290313-contam.fasta] Isoform of P42582, Homeobox protein Nkx-2.5 OS=Mus musculus GN=Nkx2-5 PE=2 SV=1 [MOUSE.fasta.20160308]
Organism:	Mus musculus
Length:	318 amino acids
Gene Ontology:
Cellular Component:	nucleus [UNKNOWN][IDA] transcription factor complex [IDA] cytoplasm [IDA]
Biological Process:	positive regulation of calcium ion transport via voltage-gated calcium channel activity [IMP] endoderm development [TAS] tongue development [IEP] regulation of transcription [IEA] cardiac muscle contraction [IMP] cardiac ventricle formation [IGI] atrioventricular node cell fate commitment [IMP] heart morphogenesis [IMP] positive regulation of transcription, DNA-dependent [IDA] cardiac ventricle morphogenesis [IMP] positive regulation of transcription via serum response element binding [IDA] atrioventricular node cell development [IMP] heart looping [IMP] ventricular cardiac myofibril development [IMP] cardiac muscle cell differentiation [IEP][IGI][IMP] proepicardium development [IMP] pharyngeal system development [IGI] ventricular trabecular myocardium morphogenesis [IMP] positive regulation of cardioblast differentiation [IEP][IMP] atrial cardiac muscle cell development [IEP] ventricular cardiac muscle cell development [IEP] negative regulation of cardiac muscle cell apoptosis [IMP] multicellular organismal development [IEA] positive regulation of transcription initiation from RNA polymerase II promoter [IDA] hemopoiesis [IMP] positive regulation of cell proliferation [IGI] outflow tract morphogenesis [IGI][IMP] pulmonary myocardium development [IMP] spleen development [IEP] vasculogenesis [IMP] positive regulation of heart contraction [IMP] positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IDA][IGI] cardiac muscle tissue development [IMP] apoptosis involved in heart morphogenesis [IMP] heart trabecula formation [IMP] adult heart development [IEP][IMP] negative regulation of transcription from RNA polymerase II promoter [IDA][IGI] heart development [IGI][IMP] positive regulation of gene-specific transcription from RNA polymerase II promoter [IMP] embryonic heart tube left/right pattern formation [IMP] cardiac conduction system development [UNKNOWN] atrioventricular node development [IMP] regulation of transcription, DNA-dependent [IEA] embryonic heart tube development [IGI] bundle of His development [IGI] cardiac Purkinje fiber cell differentiation [IMP] regulation of transcription from RNA polymerase II promoter [IDA] negative regulation of Wnt receptor signaling pathway through beta-catenin [IDA] thyroid gland development [IMP] negative regulation of apoptosis [IGI] cell differentiation [IGI] positive regulation of sodium ion transport [IMP] regulation of cardiac muscle contraction [IMP]
Molecular Function:	DNA binding [IDA] transcription factor activity [UNKNOWN][IDA] protein homodimerization activity [UNKNOWN][IDA] protein binding [IPI] serum response element binding [IDA] transcription regulator activity [IEA] protein heterodimerization activity [IPI] sequence-specific DNA binding [UNKNOWN] chromatin binding [UNKNOWN][IDA] transcription activator activity [IDA] transcription repressor activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFPSPALTPT PFSVKDILNL EQQQRSLASG DLSARLEATL APASCMLAAF KPEAYSGPEA  60
   61 AASGLAELRA EMGPAPSPPK CSPAFPAAPT FYPGAYGDPD PAKDPRADKK ELCALQKAVE 120
  121 LDKAETDGAE RPRARRRRKP RVLFSQAQVY ELERRFKQQR YLSAPERDQL ASVLKLTSTQ 180
  181 VKIWFQNRRY KCKRQRQDQT LELLGPPPPP ARRIAVPVLV RDGKPCLGDP AAYAPAYGVG 240
  241 LNAYGYNAYP YPSYGGAACS PGYSCAAYPA APPAAQPPAA SANSNFVNFG VGDLNTVQSP 300
  301 GMPQGNSGVS TLHGIRAW

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: NKX25_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: