Protein Overview: Dscam-PAV

General Information:
Name(s) found:	Dscam-PAV / FBpp0110362 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|116007616\|ref\|NP_001036504.1\| down syndrome cell adhesion molecule, isoform AV [Drosophila melanogaster] [NCBI NR] gi\|113194609\|gb\|ABI31055.1\| down syndrome cell adhesion molecule, isoform AV [Drosophila melanogaster] [NCBI NR] The gene Down syndrome cell adhesion molecule is referred to in FlyBase by the symbol Dmel\Dscam (CG17800, FBgn0033159). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3207059..3269374. It has the cytological map location 43A4-43B1. There is experimental evidence that it has the molecular function</span>: protein binding; bacterial binding; protein homodimerization activity; axon guidance receptor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite self-avoidance; axon extension involved in axon guidance; axon guidance; phagocytosis; central nervous system morphogenesis; neuron development; axonal fasciculation; mushroom body development; peripheral nervous system development. 120 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: nervous system; multi-cell-component structure; organ system; adult segment; embryonic nervous system; commissure; antennal segment; adult brain; peripheral nervous system; mushroom body. It has 59 annotated transcripts and 59 annotated polypeptides. [FlyBase] type=protein; loc=2R:complement(3208188..3208269,3209088..3209154,3210065..3210223,3210281..3210461,3210527..3210837,3211324..3211473,3212087..3212242,3213657..3213869,3216794..3216960,3217018..3217194,3217248..3217356,3217422..3218105,3218164..3218319,32 [fly-100309-contam.fasta] CG17800-PAV [Drosophila melanogaster] [nr-271106-contam.fasta] Down syndrome cell adhesion molecule CG17800-PAV [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2R:complement(3208188..3208269,3209088..3209154,3210065..3210223,3210281..3210461,3210527..3210837,3211324..3211473,3212087..3212242,3213657..3213869,3216794..3216960,3217018..3217194,3217248..3217356,3217422..3218105,3218164..3218319,3218481..3219707,3219766..3219885,3234512..3234799,3235354..3235515,3235636..3236480,3244905..3245028,3249223..3249372,3251100..3251270,3255893..3256237,3265039..3265099); ID=FBpp0110362; name=Dscam-PAV; parent=FBgn0033159,FBtr0111068; dbxref=FlyBase:FBpp0110362,FlyBase_Annotation_IDs:CG17800-PAV,REFSEQ:NP_001036504,GB_protein:ABI31055; MD5=9504d6e3b1afbf45618ffb289194fb5c; length=2034; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2R:complement(3208188..3208269,3209088..3209154,3210065..3210223,3210281..3210461,3210527..3210837,3211324..3211473,3212087..3212242,3213657..3213869,3216794..3216960,3217018..3217194,3217248..3217356,3217422..3218105,3218164..3218319,3218481..3219707,3219766..3219885,3234512..3234799,3235354..3235515,3235636..3236480,3244905..3245028,3249223..3249372,3251100..3251270,3255893..3256237,3265039..3265099); ID=FBpp0110362; name=Dscam-PAV; parent=FBgn0033159,FBtr0111068; dbxref=FlyBase:FBpp0110362,FlyBase_Annotation_IDs:CG17800-PAV,REFSEQ:NP_001036504,GB_protein:ABI31055; MD5=9504d6e3b1afbf45618ffb289194fb5c; length=2034; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Down syndrome cell adhesion molecule, isoform AV OS=Drosophila melanogaster GN=Dscam PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=2R:complement(3208188..3208269,3209088..3209154,3210065..3210223,3210281..3210461,3210527..3210837,3211324..3211473,3212087..3212242,3213657..3213869,3216794..3216960,3217018..3217194,3217248..3217356,3217422..3218105,3218164..3218319,3218481..3219707,3219766..3219885,3234512..3234799,3235354..3235515,3235636..3236480,3244905..3245028,3249223..3249372,3251100..3251270,3255893..3256237,3265039..3265099); ID=FBpp0110362; name=Dscam-PAV; parent=FBgn0033159,FBtr0111068; dbxref=FlyBase:FBpp0110362,FlyBase_Annotation_IDs:CG17800-PAV,REFSEQ:NP_001036504,GB_protein:ABI31055,FlyMine:FBpp0110362,modMine:FBpp0110362; MD5=9504d6e3b1afbf45618ffb289194fb5c; length=2034; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2R:complement(join(7377534..7377594,7368388..7368732,7363595..7363765,7361718..7361867,7357400..7357523,7348131..7348975,7347849..7348010,7347007..7347294,7332261..7332380,7330976..7332202,7330659..7330814,7329917..7330600,7329743..7329851,7329513..7329689,7329289..7329455,7326152..7326364,7324582..7324737,7323819..7323968,7323022..7323332,7322776..7322956,7322560..7322718,7321583..7321649,7320683..7320764)); ID=FBpp0110362; name=Dscam1-PAV; parent=FBgn0033159,FBtr0111068; dbxref=FlyBase:FBpp0110362,FlyBase_Annotation_IDs:CG17800-PAV,REFSEQ:NP_001036504,GB_protein:ABI31055,FlyMine:FBpp0110362,modMine:FBpp0110362; MD5=9504d6e3b1afbf45618ffb289194fb5c; length=2034; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2R:complement(join(7377534..7377594,7368388..7368732,7363595..7363765,7361718..7361867,7357400..7357523,7348131..7348975,7347849..7348010,7347007..7347294,7332261..7332380,7330976..7332202,7330659..7330814,7329917..7330600,7329743..7329851,7329513..7329689,7329289..7329455,7326152..7326364,7324582..7324737,7323819..7323968,7323022..7323332,7322776..7322956,7322560..7322718,7321583..7321649,7320683..7320764)); ID=FBpp0110362; name=Dscam1-PAV; parent=FBgn0033159,FBtr0111068; dbxref=FlyBase:FBpp0110362,FlyBase_Annotation_IDs:CG17800-PAV,REFSEQ:NP_001036504,GB_protein:ABI31055,FlyMine:FBpp0110362,modMine:FBpp0110362; MD5=9504d6e3b1afbf45618ffb289194fb5c; length=2034; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of A0A0B4K823, Down syndrome cell adhesion molecule 1, isoform AV OS=Drosophila melanogaster GN=Dscam1 PE=1 SV=1 [DROME.fasta.20160308] FBpp0110362 type=protein; loc=2R:complement(join(7377534..7377594,7368388..7368732,7363595..7363765,7361718..7361867,7357400..7357523,7348131..7348975,7347849..7348010,7347007..7347294,7332261..7332380,7330976..7332202,7330659..7330814,7329917..7330600,7329743..7329851,7329513..7329689,7329289..7329455,7326152..7326364,7324582..7324737,7323819..7323968,7323022..7323332,7322776..7322956,7322560..7322718,7321583..7321649,7320683..7320764)); ID=FBpp0110362; name=Dscam1-PAV; parent=FBgn0033159,FBtr0111068; dbxref=FlyBase:FBpp0110362,FlyBase_Annotation_IDs:CG17800-PAV,REFSEQ:NP_001036504,GB_protein:ABI31055,FlyMine:FBpp0110362,modMine:FBpp0110362; MD5=9504d6e3b1afbf45618ffb289194fb5c; length=2034; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2R:complement(join(7377534..7377594,7368388..7368732,7363595..7363765,7361718..7361867,7357400..7357523,7348131..7348975,7347849..7348010,7347007..7347294,7332261..7332380,7330976..7332202,7330659..7330814,7329917..7330600,7329743..7329851,7329513..7329689,7329289..7329455,7326152..7326364,7324582..7324737,7323819..7323968,7323022..7323332,7322776..7322956,7322560..7322718,7321583..7321649,7320683..7320764)); ID=FBpp0110362; name=Dscam1-PAV; parent=FBgn0033159,FBtr0111068; dbxref=FlyBase:FBpp0110362,FlyBase_Annotation_IDs:CG17800-PAV,REFSEQ:NP_001036504,GB_protein:ABI31055,UniProt/TrEMBL:Q0E9L6,FlyMine:FBpp0110362,modMine:FBpp0110362; MD5=9504d6e3b1afbf45618ffb289194fb5c; length=2034; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	2034 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [ISS] dendrite [IDA] neuronal cell body [IDA] axon [IDA]
Biological Process:	mushroom body development [IMP] dendrite self-avoidance [IDA][IMP] phagocytosis [IMP] axon guidance [IGI][IMP][TAS] peripheral nervous system development [IMP] neuron development [IMP] central nervous system morphogenesis [IMP] axonal fasciculation [IMP] axon extension involved in axon guidance [IMP]
Molecular Function:	protein binding [IDA] protein homodimerization activity [IPI] axon guidance receptor activity [IMP][NAS] bacterial cell surface binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMPNERLKW LMLFAAVALI ACGSQTLAAN PPDADQKGPV FLKEPTNRID FSNSTGAEIE  60
   61 CKASGNPMPE IIWIRSDGTA VGDVPGLRQI SSDGKLVFPP FRAEDYRQEV HAQVYACLAR 120
  121 NQFGSIISRD VHVRAVVHQF YQTRVIDEFV LRGNSATLKC LVPSFVADFI DVEGWIDEEG 180
  181 VEILRPLPDD SVDGKYLVLP SGELHIREVG PEDGYKSYQC RTKHRLTGET RLSATKGRLV 240
  241 ITEPVGSVAP KVDIKDEINY ARVGQDRSLA IVCPAQSYPV PAFRWYKFIE GTTRKQAVVL 300
  301 NDRVKQVSGT LIIKDAVVED SGKYLCVVNN SVGGESVETV LTVTAPLSAK IDPPTQTVDF 360
  361 GRPAVFTCQY TGNPIKTVSW MKDGKAIGHS EPVLRIESVK KEDKGMYQCF VRNDQESAEA 420
  421 SAELKLGGRF DPPVIRQAFQ EETMEPGPSV FLKCVAGGNP TPEISWELDG KKIANNDRYQ 480
  481 VGQYVTVNGD VVSYLNITSV HANDGGLYKC IAKSKVGVAE HSAKLNVYGL PYIRQMEKKA 540
  541 IVAGETLIVT CPVAGYPIDS IVWERDNRAL PINRKQKVFP NGTLIIENVE RNSDQATYTC 600
  601 VAKNQEGYSA RGSLEVQVMV LPQIVPFDFG EETVNELDMV SASCTVNKGD LPIDVAWTKN 660
  661 GGRVYTNDGI VVTKTSTRMS VLSIESARAR HAGNYSCVAT NNAGETRQWA VLAVNVPPRW 720
  721 ILEPTDKAFA QGSDAKVECK ADGFPKPQVT WKKAVGDTPG EYKDLKKSDN IRVEEGTLHV 780
  781 DNIQKTNEGY YLCEAINGIG SGLSAVIMIS VQAPPEFTEK LRNQTARRGE PAVLQCEAKG 840
  841 EKPIGILWNM NNMRLDPKND NRYTIREEIL STGVMSSLSI KRTERSDSAL FTCVATNAFG 900
  901 SDDASINMIV QEVPEMPYAL KVLDKSGRSV QLSWAQPYDG NSPLDRYIIE FKRSRASWSE 960
  961 IDRVIVPGHT TEAQVQKLSP ATTYNIRIVA ENAIGTSQSS EAVTIITAEE APSGKPQNIK1020
 1021 VEPVNQTTMR VTWKPPPRTE WNGEILGYYV GYKLSNTNSS YVFETINFIT EEGKEHNLEL1080
 1081 QNLRVYTQYS VVIQAFNKIG AGPLSEEEKQ FTAEGTPSQP PSDTACTTLT SQTIRVGWVS1140
 1141 PPLESANGVI KTYKVVYAPS DEWYDETKRH YKKTASSDTV LHGLKKYTNY TMQVLATTAG1200
 1201 GDGVRSVPIH CQTEPDVPEA PTDVKALVMG NAAILVSWRP PAQPNGIITQ YTVYSKAEGA1260
 1261 ETETKTQKVP HYQMSFEATE LEKNKPYEFW VTASTTIGEG QQSKSIVAMP SDQVPAKIAS1320
 1321 FDDTFTATFK EDAKMPCLAV GAPQPEITWK IKGVEFSAND RMRVLPDGSL LIKSVNRQDA1380
 1381 GDYSCHAENS IAKDSITHKL IVLAPPQSPH VTLSATTTDA LTVKLKPHEG DTAPLHGYTL1440
 1441 HYKPEFGEWE TSEVSVDSQK HNIEGLLCGS RYQVYATGFN NIGAGEASDI LNTRTKGQKP1500
 1501 KLPEKPRFIE VSSNSVSLHF KAWKDGGCPM SHFVVESKKR DQIEWNQISN NVKPDNNYVV1560
 1561 LDLEPATWYN LRITAHNSAG FTVAEYDFAT LTVTGGTIAP LDDGSGHGNV HTRIRLPAWM1620
 1621 PEWLDLNFMV PLIATVVVVA VGICVVCVAL SRRRADDMRG GQKDVYYDVV YNQTMGPGAT1680
 1681 LDKRRPDLRD ELGYIAPPNR KLPPVPGSNY NTCDRIKRGR GGLRSNHSTW DPRRNPNLYE1740
 1741 ELKAPPVPMH GNHYGHAHGN AECHYRHPGM EDEICPYATF HLLGFREEMD PTKAMNFQTF1800
 1801 PHQNGHAGPV PGHAGTMLPP GHPGHVHSRS GSQSMPRANR YQRKNSQGGQ SSIYTPAPEY1860
 1861 DDPANCAEED QYRRYTRVNS QGGSLYSGPG PEYDDPANCA PEEDQYGSQY GGPYGQPYDH1920
 1921 YGSRGSMGRR SIGSARNPGN GSPEPPPPPP RNHDMSNSSF NDSKESNEIS EAECDRDHGP1980
 1981 RGNYGAVKRS PQPKDQRTTE EMRKLIERNE TGPKQLQLQQ ANGAGFTAYD TMAV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..428]	PSI-BLAST	78.221849	No description for 2v5sA was found.
2	View Details	[429..537]	PSI-BLAST	33.69897	No description for 2v9qA was found.
3	View Details	[538..820]	PSI-BLAST	33.0	Crystal Structure of the 3 Ig form of FGFR3c in complex with FGF1
4	View Details	[821..1281]	PSI-BLAST	29.39794	No description for 2v5yA was found.
5	View Details	[1282..1321]	PSI-BLAST	13.69897	No description for 1zlgA was found.
6	View Details	[1322..1392]	PSI-BLAST	32.69897	No description for 2nziA was found.
7	View Details	[1393..1598]	PSI-BLAST	10.30103	No description for 2ibgA was found.
8	View Details	[1599..1776]	deduced	N/A	No confident structure predictions are available.
9	View Details	[1777..1862]	deduced	N/A	No confident structure predictions are available.
10	View Details	[1863..2034]	MSA	2.109995	View MSA. No confident structure predictions are available.

Protein Overview: Dscam-PAV

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: