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Protein Overview: gi|109494796

General Information:
Name(s) found: gi|109494796 [NCBI NR]
Description(s) found:
Found 3 descriptions.
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  • gi|109494796|ref|XP_001068336.1| PREDICTED: similar to DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (P460) [Rattus norvegicus] [NCBI NR]
    • Organism: Rattus norvegicus
    Length: 4126 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IEA]
    transcription factor complex [UNKNOWN]
    nonhomologous end joining complex [UNKNOWN]
    DNA-dependent protein kinase-DNA ligase 4 complex [UNKNOWN]
    cellular_component [ND]
    nucleoplasm [UNKNOWN]
    Biological Process: biological_process [ND]
    germ cell programmed cell death [UNKNOWN]
    T cell differentiation in the thymus [UNKNOWN]
    T cell receptor V(D)J recombination [UNKNOWN]
    immunoglobulin V(D)J recombination [UNKNOWN]
    telomere maintenance [UNKNOWN]
    T cell lineage commitment [UNKNOWN]
    brain development [UNKNOWN]
    double-strand break repair via nonhomologous end joining [IEA]
    double-strand break repair [UNKNOWN]
    protein destabilization [UNKNOWN]
    cellular response to insulin stimulus [UNKNOWN]
    heart development [UNKNOWN]
    B cell lineage commitment [UNKNOWN]
    somitogenesis [UNKNOWN]
    pro-B cell differentiation [UNKNOWN]
    apoptosis [UNKNOWN]
    positive regulation of apoptosis [UNKNOWN]
    lymphocyte differentiation [UNKNOWN]
    response to gamma radiation [UNKNOWN]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN]
    peptidyl-serine phosphorylation [UNKNOWN]
    Molecular Function: DNA binding [IEA]
    DNA-dependent protein kinase activity [UNKNOWN][IEA]
    ATP binding [IEA]
    protein binding [UNKNOWN]
    transcription factor binding [UNKNOWN]
    protein serine/threonine kinase activity [UNKNOWN]
    binding [IEA]
    phosphotransferase activity, alcohol group as acceptor [IEA]
    kinase activity [IEA]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADPGAGLRC WLLQLQEFVS AADRYNAAGA SYQLIRGLGQ ECVLSTCSAV QALQISLVFS  60
   61 KEFGLLVFIR KSLSIDEFRD CREEALKFLC VFLEKIDQKV LHYSFDIKNT CISVYTKDRT 120
  121 AKCKIPALDL LIKLLKILRS SRVMDEFKIG ELFNKFYGEL VSKSKLPDTV LEKVYELLGV 180
  181 LGEVHPSEMV NHSENLFRAF LGELKTQMTS TVREPKFPVL AGCLKGLSSL LCNFTKSMEE 240
  241 DPQTSKEIFG FTLKAIRPQI EMKRYAVPLA GLRLLTLHAS QFTTCLLDNY ITLFEVLSKW 300
  301 CNHTNVELKK AAHSALESFL KQISFTVAED AELHKSKLKY FMEQFYGIIR NADSNNKDLA 360
  361 IAIRGYGLFA GPCKVINAKD VDFMYVELIQ RCKQMFLTQT DATEDHVYQM PSFLQSIASV 420
  421 LLYLDTVPEV YTPVLEHLMV VQIDSFPQYS PKMQLVCCKA LVKVFLSLTE KGPVHWNCIS 480
  481 AVVHQGLIRI CSKPVVLQKD VESRSENRWA SEEVRMGRWK VPTYKDYVDL FQNLLGCDQM 540
  541 ADFILGDETF LFVNSSLKSL NHLLYDEFIR SVLKIVEKLD LTLEKQTTGE QEDERTADVW 600
  601 VIPTSDPAAN LHPIKPNDFS AFINLVEFCR EILPKKQVSF FEPWVYSFAY ELILQSTRLP 660
  661 LISGFYKLLS IAVKNARKIK YFEGVSPKCL KHSPENTEKH SCFALFAKFG KEVSVKMKQY 720
  721 KDELLASCLT FVLSLPPDII KLDVRAYVPA LQMAFKLGLS HLPLAEIGLH ALKEWSVHID 780
  781 KSIMQPYYKD IVPCLDGYLN TSTLSDETKS HWEVSALSRA ARKGFNRDVV KLLKRTRNVT 840
  841 SDEALSLEEI RIRVVQILGS LGGQINKNLI TATSGERMKK YVAWDREKRL SFAVPFREMK 900
  901 PVIYLDVFLP RVTELALSAS DRQTKVAACE LLHSMVMFML GRATQMPEGQ GLPPMYQLYK 960
  961 HMFPVLLKLA CDVDQVTRQL YEPLVMQLIH WFTNNKKFES QDTVALLEAI LDGIVDPVDS1020
 1021 TLRDFCGQCV QEFLKWSIKQ TTPQQQEKSP VNSKSLFKRL YSLALHPNAF KRLGAALAFN1080
 1081 HIYKEFREEG SLVEQFVFEA LVTYMESLAL AHADEKSLGT IQQCCDAIDH LRRIIEKKYI1140
 1141 SLNKAKKRRL PRGFPPLTSL CLLDLVKWLF AHCGRPQTEC RHKSIELFYK FVPLLPGNKS1200
 1201 PSLWLRDLIK AEGISFLINT FEGGASSSGQ PSGILAQPTL LHLQGPVSLR GMLQWLDHLL1260
 1261 AALECYNTFI EEKTVQVQEV LGTEVQSSLL KSVAFFLESI ATCDARTVEQ RFGTGLTGPP1320
 1321 SVQEEEKYNY SKCTVLVRIM EFTTTLLVTF PEDCKLLEKD LCNTKLMKVL VKMLCEPLSI1380
 1381 GFNIGDVQVM NHLPSICVNL LKALRKSPYR DKLETHLKEK VTAQSVEELC AINLCSSAAC1440
 1441 QERTKLLSLL SACKQLHKAG FSHIISASQS TALNHSIGMR LLSLVYNGIA PAQEKQYLQS1500
 1501 LDPSCKSLAS GLLELAFAFG GLCEHLVSLL LNSSMLSTQY LGSSQRNISF SHGEYFYSLF1560
 1561 PEVINTELLK SLDVTVSRLL ESSSDNPKMV STILNGMLDM SFRDRAVQKH QGLKLATAIL1620
 1621 QNWRKCDSWW APDSAPESKT TVLSLLAKML QIDSTLSFDT NHSSFSEIFT TYANLLADTK1680
 1681 LGLHLKGQAV ILLPFFTRVT EDRLGDLKHI LEKFIVLNFP MKSDEFPPDS LKYNNYVDCM1740
 1741 KKFLDALELS QSPMLLQLMT DILCREQQHI MEELFQTTFK RIARRSPCVT QLNLLESVYT1800
 1801 MFRKGGLLSD VTQAFVDRSL LTLLWHCDLD TLKEFFSRIV VEAIDVLKSR FTKLNDTFDT1860
 1861 QITKKMCYYK MLAVMYSRLL KDDVHSKESK INQAFQGSCV AEGNELTKTL LKLCHDAFTE1920
 1921 NMAGESQLLE KRRLYHCAAY NCAISLISRV FNELKFYQGF LFSEKPEKNL FIFENLIDLK1980
 1981 RCYTFPIEVE VPMERKKKYV EIRKEARDAA NGASGNPRYM SSLSYLTESS LSEEMSQFDF2040
 2041 STGVQSYSYS SQDRKPTTGH FQRREHQDSM AQDDIIELEM DELNQHECMA PMTSLIKHMQ2100
 2101 RNVIAPKGQE GSISKDLPPW MKFLHDKLEN ASVSLNIRLF LAKLVINTEE VFRPYAKHWL2160
 2161 GPLLQLAVCE NIGEGIHYMI VEIVATILSW TGLATPTGVP KYEVLANRLL YFLMKYVFHP2220
 2221 KRAVFRHNLE IIKTLVECWK ECLSIPYRLI FEKFSNKDPN SKDNSVGIQL LGIVVANNLP2280
 2281 PYDLKGDITS AMYFEALVNN MSFVKYKEVY AAAAEVLGLI LQHVTERKHV IAESVYELVV2340
 2341 KQLKQHQNTM EDKFIVCLNK IVKGFPPLAD RFLNALFFLL PKFHGVMKTL CLEVVLCRAE2400
 2401 AITGLYLQLK SKDFLQVMRH RDDERQKVCL DIIYKMVAKL KPTELRELLN PVVEFVSHPS2460
 2461 PTCREQMYNI LMWIHDNYRD PESQMDEDSQ EIFKLAKDVL IQGLIDENLG LQLIIRNFWS2520
 2521 HETRLPSNTL DRLLALNSLY SPKIEVHFLS LATNFLLEMT RMSPDYLNPI FEHPLSECEF2580
 2581 QEYTIDPDWR FRSTVLTPMF IETQAFPSTL NTQTQEGSPS DRRQKPGQVR ATQQQYDFTP2640
 2641 TQTSVERSSF DWLTGSSIDL MADHTVFSSE SLSSSLLFSH KKSEKSQRVS WKSVGPDFGT2700
 2701 KKLGLPGDEV DNQVKSGTHS QTEILRLRRR FLKDQEKLSL LYAKRGLMEQ KLEKDIKSEL2760
 2761 KMKQDAQVVL YRSYRHGDLP DIQIQHSSLI TPLQAVAQKD PIIAKQLFSS LFSGILKEMH2820
 2821 KFRTTSEKNI IIQNLLQDFN RFLNTTFLFF PPFVSCIQEI SCQHVDLLTL DPAAVRVGCL2880
 2881 ASLQQPGGIR LLEEALLHLL PKEPPTKRIR GKTCLPPDVL RWMELAKLYR SIGEYDVLHG2940
 2941 IFSSELGTKQ DTQNALLAEA RSDYFQAANL YKEALNKLEW LDGEPTEAEK EFWEMASLDC3000
 3001 YNNLSQWKEL EYRSTVNIGS ENSLDLSKMW SKPFYQETYL PYVIRSKLKL LLQGEDNQSL3060
 3061 LTFVDEAMHK ELQQMVLELQ YSQELSLLYI LQDDIDRATY YIKNAIQIFM QNYSSIDVLL3120
 3121 YRSRLAKLQS VQTLAEIEEF LNFIRKHGDL SSLGPLRRLL KTWTSRYPDT VTDPMHIWDD3180
 3181 IITNRCFFLS KIEERLTVSP GDHSMSVDED EDSFAREGSE PKEDAHHILQ SCRFTMKMKM3240
 3241 IESSWKQNNF SLSMKLLKEM HKESKIRESW RMQWIHSFCQ LNHCRSHTQS PQEQVLTMLK3300
 3301 TITLLDESDI SNYLNKNIQA FCDQNILLGT SCRIMADALS REPACLSGLE KSKTESIFAL3360
 3361 SGSNTENTER VISGLYQRAF HHLSMAVQSA EEETQLSCWG HEAAAERAHA YMTLVGFCDQ3420
 3421 QLRKVEESAS TASQKISTEL EGYPALVVEK MLRALKLNSS EARLKFPRLL QIIEQYPEET3480
 3481 VNIIIKEISS IPCWQFIGWI GHMVALLDKE EAIAVQHTVE EIADNYPQAI IYPFIISSES3540
 3541 YSFQNTSSGH NNKAFVERIK SKLDQGGVIQ GFINALDQLS NPDMLFKDWV NDTKDELGKN3600
 3601 PVNKKNIEKL YERMYAALGD FRAPGLGPFR RKFIQTFGKE FVKSFGNGGS KLLTMKLDEF3660
 3661 RNITDSLFVR MRKDSKLPGN LKEYSPWMSE FTVKSELEIP GQYDGKSKPL PEYHVRISGF3720
 3721 DERVKVMVSL RKPKRIVIRG HDEKEYPFLV KGGEDLRQDQ RIEQLFEVMN AILSQDAACS3780
 3781 QRNMQLRTYR VVPMTSRLGL IEWIENTMTL KDLLLSNMSQ EEKVAYDSDS KAPIYDYRDW3840
 3841 LIKVSGRSDV KGYTLMYSRA NRTETVTAFR RRENKVPADL LKRAFVKMST SPEAFLALRS3900
 3901 HFASSHALLC ISHWLLGIGD RHLNNFMVAM ETGSVIGIDF GHAFGSATQF LPIPELMPFR3960
 3961 LTRQFISLML PMKETGLVCT VMVHALRAFR SCAGLLTDTM EVFVKEPSFD WKGFEQTMLR4020
 4021 KGGSWIQEIN VTEKNWYPQH KIRYAKRKLA GANPAVITCD ELRLGHEASP AFRSYVAVAR4080
 4081 GNKDYNIRAQ EPESRLSEET QVKCLVDQAT DPNILGRTWE GWEPWM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.45

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle