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Protein Overview: TRPC6

General Information:
Name(s) found: TRPC6 [HGNC (HUGO)]
Description(s) found:
Found 36 descriptions.
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  • transient receptor potential cation channel, subfamily C, member 6 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 931 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQSPAFGPR RGSSPRGAAG AAARRNESQD YLLMDSELGE DGCPQAPLPC YGYYPCFRGS  60
   61 DNRLAHRRQT VLREKGRRLA NRGPAYMFSD RSTSLSIEEE RFLDAAEYGN IPVVRKMLEE 120
  121 CHSLNVNCVD YMGQNALQLA VANEHLEITE LLLKKENLSR VGDALLLAIS KGYVRIVEAI 180
  181 LSHPAFAEGK RLATSPSQSE LQQDDFYAYD EDGTRFSHDV TPIILAAHCQ EYEIVHTLLR 240
  241 KGARIERPHD YFCKCNDCNQ KQKHDSFSHS RSRINAYKGL ASPAYLSLSS EDPVMTALEL 300
  301 SNELAVLANI EKEFKNDYKK LSMQCKDFVV GLLDLCRNTE EVEAILNGDV ETLQSGDHGR 360
  361 PNLSRLKLAI KYEVKKFVAH PNCQQQLLSI WYENLSGLRQ QTMAVKFLVV LAVAIGLPFL 420
  421 ALIYWFAPCS KMGKIMRGPF MKFVAHAASF TIFLGLLVMN AADRFEGTKL LPNETSTDNA 480
  481 KQLFRMKTSC FSWMEMLIIS WVIGMIWAEC KEIWTQGPKE YLFELWNMLD FGMLAIFAAS 540
  541 FIARFMAFWH ASKAQSIIDA NDTLKDLTKV TLGDNVKYYN LARIKWDPSD PQIISEGLYA 600
  601 IAVVLSFSRI AYILPANESF GPLQISLGRT VKDIFKFMVI FIMVFVAFMI GMFNLYSYYI 660
  661 GAKQNEAFTT VEESFKTLFW AIFGLSEVKS VVINYNHKFI ENIGYVLYGV YNVTMVIVLL 720
  721 NMLIAMINSS FQEIEDDADV EWKFARAKLW FSYFEEGRTL PVPFNLVPSP KSLFYLLLKL 780
  781 KKWISELFQG HKKGFQEDAE MNKINEEKKL GILGSHEDLS KLSLDKKQVG HNKQPSIRSS 840
  841 EDFHLNSFNN PPRQYQKIMK RLIKRYVLQA QIDKESDEVN EGELKEIKQD ISSLRYELLE 900
  901 EKSQNTEDLA ELIRELGEKL SMEPNQEETN R

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..284] PSI-BLAST 45.045757 Ankyrin-R
    2 View Details [285..428] deduced N/A No confident structure predictions are available.
    3 View Details [429..754] PSI-BLAST 16.39794 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    4 View Details [755..931] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • metal ion transmembrane transporter activity
    		•  3.06689459321273 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.89029061890648 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.66479899929908 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.59441577402651 bayes_pls_golite062009
  • calcium channel activity
    		•  2.42383730626707 bayes_pls_golite062009
  • binding
    		•  2.41068257517762 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  2.39688396372487 bayes_pls_golite062009
  • channel activity
    		•  2.39688396372487 bayes_pls_golite062009
  • cation channel activity
    		•  2.37772481426745 bayes_pls_golite062009
  • ion channel activity
    		•  2.36752848265558 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  2.26531840012081 bayes_pls_golite062009
  • gated channel activity
    		•  1.75472864911207 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.64895183402675 bayes_pls_golite062009
  • protein binding
    		•  1.54890102798695 bayes_pls_golite062009
  • signal transducer activity
    		•  1.50673806965616 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.50673806965616 bayes_pls_golite062009
  • transporter activity
    		•  1.19000052859754 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.02570255606772 bayes_pls_golite062009
  • receptor activity
    		•  0.872395596733881 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.835937200249181 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.684449236640306 bayes_pls_golite062009
  • mechanically-gated ion channel activity
    		•  0.645199153849127 bayes_pls_golite062009
  • mechanically gated channel activity
    		•  0.645199153849127 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.425387186237426 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.025521113335145 bayes_pls_golite062009
  • transcription factor binding
    		•  4.19781566800115E-4 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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