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Protein Overview: SMAD2

General Information:
Name(s) found: SMAD2 [HGNC (HUGO)]
Description(s) found:
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  • pir||S71797 MAD-2 protein homolog - human [NCBI NR]
  • gi|5174511|ref|NP_005892.1| Sma- and Mad-related protein 2 isoform 1 [Homo sapiens] [NCBI NR]
  • gi|51173730|ref|NP_001003652.1| Sma- and Mad-related protein 2 isoform 1 [Homo sapiens] [NCBI NR]
  • gi|30583683|gb|AAP36090.1| MAD, mothers against decapentaplegic homolog 2 (Drosophila) [Homo sapiens] [NCBI NR]
  • gi|2967646|gb|AAC39657.1| Smad2 [Homo sapiens] [NCBI NR]
  • gi|2695663|gb|AAC51918.1| MAD-related protein Smad2 [Homo sapiens] [NCBI NR]
  • gi|19344008|gb|AAH25699.1| SMAD family member 2 [Homo sapiens] [NCBI NR]
  • gi|189066552|dbj|BAG35802.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|15928762|gb|AAH14840.1| SMAD family member 2 [Homo sapiens] [NCBI NR]
  • gi|1575530|gb|AAB17054.1| MAD-related protein 2 [NCBI NR]
  • gi|1552530|gb|AAB17087.1| mad protein homolog [NCBI NR]
  • gi|1403713|gb|AAC50789.1| JV18-1 [Homo sapiens] [NCBI NR]
  • gi|13633914|sp|Q15796.1|SMAD2_HUMAN RecName: Full=Mothers against decapentaplegic homolog 2; Short=Mothers against DPP homolog 2; AltName: Full=Mad-related protein 2; Short=hMAD-2; AltName: Full=SMAD 2; AltName: Full=hSMAD2; AltName: Full=JV18-1 [NCBI NR]
  • gi|119583321|gb|EAW62917.1| SMAD, mothers against DPP homolog 2 (Drosophila), isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119583320|gb|EAW62916.1| SMAD, mothers against DPP homolog 2 (Drosophila), isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119583319|gb|EAW62915.1| SMAD, mothers against DPP homolog 2 (Drosophila), isoform CRA_b [Homo sapiens] [NCBI NR]
  • SMAD family member 2 [HGNC (HUGO)]
  • Mothers against decapentaplegic homolog 2 OS=Homo sapiens GN=SMAD2 PE=1 SV=1 [Swiss-Prot]
  • (Q15796) Mothers against decapentaplegic homolog 2 (SMAD 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2) [Swiss-Prot]
  • Splice isoform Long of Q15796 [hmr_yeast5_DM3-1_pombe.fasta]
  • MAD, mothers against decapentaplegic homolog 2; MAD (mothers against decapentaplegic, Drosophila) homolog 2; Mothers against decapentaplegic, Drosophila, homolog of, 2 [HMR_022704.fasta]
  • Sma- and Mad-related protein 2; Mad-related protein 2; Mad protein homolog; Mad, mothers against decapentaplegic homolog 2 (Drosophila); mother against DPP homolog 2 [071204_hmrz_cont.fasta]
  • Sma- and Mad-related protein 2 [Homo sapiens]gi|5174511|ref|NP_005892.1| Sma- and Mad-related protein 2 [Homo sapiens]gi|30583683|gb|AAP36090.1| MAD, mothers against decapentaplegic homolog 2 (Drosophila) [Homo sapiens]gi|19344008|gb|AAH25699.1| Sma- a [nrdb_11152004_Chlamydomonas]
  • Mothers against decapentaplegic homolog 2 (SMAD 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform Long of Mothers against decapentaplegic homolog 2 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_005901) MAD, mothers against decapentaplegic homolog 2 (Drosophila); MAD (mothers against decapentaplegic, Drosophila) homolog 2; Mothers against decapentaplegic, Drosophila, homolog of, 2 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Sma- and Mad-related protein 2 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Sma- and Mad-related protein 2; Mad-related protein 2; Mad protein homolog; Mad, mothers against decapentaplegic homolog 2 (Drosophila); mother against DPP homolog 2 [Homo sapiens] [HumanGallus06162005.fasta]
  • MAD, mothers against decapentaplegic homolog 2; MAD (mothers against decapentaplegic, Drosophila) homolog 2; Mothers against decapentaplegic, Drosophila, homolog of, 2 [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Mothers against decapentaplegic homolog 2 (Mothers against DPP homolog 2) (Mad-related protein 2) (hMAD-2) (SMAD 2) (hSMAD2) (JV18-1) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • SMAD, mothers against DPP homolog 2 (Drosophila), isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • SMAD family member 2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • MAD, mothers against decapentaplegic homolog 2 (Drosophila) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • MAD-related protein Smad2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • JV18-1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Smad2 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • mad protein homolog [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • MAD-related protein 2 [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform Long of Mothers against decapentaplegic homolog 2 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Sma- and Mad-related protein 2 isoform 1 [Homo sapiens] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SMAD2 Isoform Long of Mothers against decapentaplegic homolog 2 [human-ipi-250309-contam.fasta]
  • IPI:IPI00019548.1|SWISS-PROT:Q15796-1|TREMBL:Q53XR6|ENSEMBL:ENSP00000262160;ENSP00000384449|REFSEQ:NP_001003652;NP_005892|H-INV:HIT000039967|VEGA:OTTHUMP00000073105;OTTHUMP00000073107;OTTHUMP00000163489 Tax_Id=9606 Gene_Symbol=SMAD2 Isoform Long of Mother [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=SMAD2 Isoform Long of Mothers against decapentaplegic homolog 2 ENSG00000175387 IPI00019548 IPI00220364 IPI00385246 IPI00646977 IPI00639978 IPI00643248 IPI00645481 [drosphohumanreversed.fasta]
  • mothers against decapentaplegic homolog 2 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q15796; RecName: Full=Mothers against decapentaplegic homolog 2; AltName: Full=Mad-related protein 2; AltName: Full=SMAD family member 2; AltName: Full=JV18-1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform Long of Mothers against decapentaplegic homolog 2 OS=Homo sapiens GN=SMAD2 [011711_HMR.fasta]
  • IPI:IPI00019548.1|SWISS-PROT:Q15796-1|TREMBL:Q53XR6|ENSEMBL:ENSP00000262160;ENSP00000384449|REFSEQ:NP_001003652;NP_005892|H-INV:HIT000039967|VEGA:OTTHUMP00000073105;OTTHUMP00000073107;OTTHUMP00000163489 Tax_Id=9606 Gene_Symbol=SMAD2 Isoform Long of Mothers against decapentaplegic homolog 2 [ipi.HUMAN.fasta.20100406]
  • Mothers against decapentaplegic homolog 2 n=27 Tax=Euteleostomi RepID=SMAD2_HUMAN [UniProt_Xenopus_laevis_01-01-2011_reversed.fasta]
  • GeneSymbol=SMAD2 Synonyms=JV18|JV18-1|MADH2|MADR2|MGC22139|MGC34440|hMAD-2|hSMAD2 mothers against decapentaplegic homolog 2 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00019548.1|SWISS-PROT:Q15796-1|TREMBL:Q53XR6|ENSEMBL:ENSP00000262160;ENSP00000384449|REFSEQ:NP_001003652;NP_005892|H-INV:HIT000039967|VEGA:OTTHUMP00000163489 Tax_Id=9606 Gene_Symbol=SMAD2 Isoform Long of Mothers against decapentaplegic homolog 2 [ipi.HUMAN.20110912.fasta]
  • Mothers against decapentaplegic homolog 2 GN=SMAD2 [Doctor+uniprot-HUMAN-120911.fasta]
  • Mothers against decapentaplegic homolog OS=Homo sapiens GN=SMAD2 PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 467 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE  60
   61 LEKAITTQNC NTKCVTIPST CSEIWGLSTP NTIDQWDTTG LYSFSEQTRS LDGRLQVSHR 120
  121 KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV 180
  181 PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS 240
  241 MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY ELNQRVGETF HASQPSLTVD 300
  301 GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL SDSAIFVQSP 360
  361 NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK 420
  421 GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..174] PSI-BLAST 57.30103 Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution
    2 View Details [175..249] MSA 2.089996 View MSA. No confident structure predictions are available.
    3 View Details [250..467] PSI-BLAST 106.0 Smad2 MH2 domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • SMAD binding
    		•  9.3718253521769 bayes_pls_golite062009
  • R-SMAD binding
    		•  9.05113862383896 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  5.17758651944685 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  4.95270065635384 bayes_pls_golite062009
  • co-SMAD binding
    		•  4.57538059815089 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  4.49077041445033 bayes_pls_golite062009
  • binding
    		•  3.6561903894619 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.49687772656017 bayes_pls_golite062009
  • protein binding
    		•  3.44553762357492 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.3543221973342 bayes_pls_golite062009
  • signal transducer activity
    		•  3.3543221973342 bayes_pls_golite062009
  • DNA binding
    		•  3.30334070294767 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  3.25693690222359 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.21526555447097 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  3.08220855629618 bayes_pls_golite062009
  • transcription activator activity
    		•  2.94935902482394 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  2.94401714632865 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.88406197124131 bayes_pls_golite062009
  • activin binding
    		•  2.85561990563659 bayes_pls_golite062009
  • transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
    		•  2.75979335370845 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.61166537801555 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  2.57320437127906 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  2.57320437127906 bayes_pls_golite062009
  • phosphatase activity
    		•  2.46582579847871 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.41505949322677 bayes_pls_golite062009
  • promoter binding
    		•  2.30493918456602 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.1294440466744 bayes_pls_golite062009
  • transcription factor activity
    		•  2.08449567315174 bayes_pls_golite062009
  • collagen binding
    		•  1.9825610927799 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.88096476099716 bayes_pls_golite062009
  • kinase activity
    		•  1.82476774968305 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.74929788315626 bayes_pls_golite062009
  • protein kinase activity
    		•  1.73373132141588 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.66058356077795 bayes_pls_golite062009
  • transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
    		•  1.61493700485683 bayes_pls_golite062009
  • chromatin binding
    		•  1.44267609273288 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.32552524966562 bayes_pls_golite062009
  • transferase activity
    		•  1.29860325699399 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.21988722144674 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.1868962075754 bayes_pls_golite062009
  • receptor binding
    		•  1.1261895404991 bayes_pls_golite062009
  • histone binding
    		•  1.01074250987871 bayes_pls_golite062009
  • transcription factor binding
    		•  0.95553719139833 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.9108432673413 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.90981150861416 bayes_pls_golite062009
  • ubiquitin protein ligase binding
    		•  0.85140744915405 bayes_pls_golite062009
  • I-SMAD binding
    		•  0.605133087848961 bayes_pls_golite062009
  • RNA binding
    		•  0.403713641965787 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.372418193032456 bayes_pls_golite062009
  • enzyme binding
    		•  0.34998623523914 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.33340925100096 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.15013949452504 bayes_pls_golite062009
  • identical protein binding
    		•  0.0513801649373811 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.0339057097360133 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle