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Protein Overview: PPID

General Information:
Name(s) found: PPID [HGNC (HUGO)]
Description(s) found:
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  • gi|729274|sp|Q08752.3|PPID_HUMAN RecName: Full=40 kDa peptidyl-prolyl cis-trans isomerase; Short=PPIase; Short=Rotamase; AltName: Full=Cyclophilin-40; Short=CYP-40; AltName: Full=Cyclophilin-related protein [NCBI NR]
  • gi|51234143|gb|AAT97986.1| peptidylprolyl isomerase D (cyclophilin D) [Homo sapiens] [NCBI NR]
  • gi|4826932|ref|NP_005029.1| peptidylprolyl isomerase D [Homo sapiens] [NCBI NR]
  • pir||A45981 peptidylprolyl isomerase (EC 5.2.1.8) CyP-40 - human [NCBI NR]
  • gi|348910|gb|AAA35731.1| cyclophilin-40 [NCBI NR]
  • gi|21265158|gb|AAH30707.1| Peptidylprolyl isomerase D [Homo sapiens] [NCBI NR]
  • gi|189054129|dbj|BAG36649.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|1769812|dbj|BAA09923.1| cyclophilin 40 [Homo sapiens] [NCBI NR]
  • gi|119625258|gb|EAX04853.1| peptidylprolyl isomerase D (cyclophilin D) [Homo sapiens] [NCBI NR]
  • peptidylprolyl isomerase D [HGNC (HUGO)]
  • Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens GN=PPID PE=1 SV=3 [Swiss-Prot]
  • 40 kDa peptidyl-prolyl cis-trans isomerase [hmr_yeast5_DM3-1_pombe.fasta]
  • peptidylprolyl isomerase D; cyclophilin 40; cyclophilin D; 40 kDa peptidyl-prolyl cis-trans isomerase D; PPIase; rotamase; cyclophilin-related protein [HMR_022704.fasta]
  • peptidylprolyl isomerase D [Homo sapiens]gi|51234143|gb|AAT97986.1| peptidylprolyl isomerase D (cyclophilin D) [Homo sapiens]gi|21265158|gb|AAH30707.1| Peptidylprolyl isomerase D [Homo sapiens]gi|729274|sp|Q08752|PPID_HUMAN 40 kDa peptidyl-prolyl cis-t [nrdb_11152004_Chlamydomonas]
  • 40 kDa peptidyl-prolyl cis-trans isomerase (PPIase) (Rotamase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • (NM_005038) peptidylprolyl isomerase D (cyclophilin D); hCyP40 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • peptidylprolyl isomerase D [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • peptidylprolyl isomerase D; cyclophilin 40; cyclophilin D; 40 kDa peptidyl-prolyl cis-trans isomerase D; PPIase; rotamase; cyclophilin-related protein [Homo sapiens] [HumanGallus06162005.fasta]
  • peptidylprolyl isomerase D (cyclophilin D); hCyP40 [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • cyclophilin 40 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • peptidylprolyl isomerase D (cyclophilin D) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Peptidylprolyl isomerase D (cyclophilin D) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • cyclophilin-40 [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PPID 40 kDa peptidyl-prolyl cis-trans isomerase [human-ipi-250309-contam.fasta]
  • IPI:IPI00003927.5|SWISS-PROT:Q08752|TREMBL:B2R9V2;Q05DH6;Q6FGM6|ENSEMBL:ENSP00000303754|REFSEQ:NP_005029|H-INV:HIT000041115 Tax_Id=9606 Gene_Symbol=PPID 40 kDa peptidyl-prolyl cis-trans isomerase [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 40 kDa peptidyl-prolyl cis-trans isomerase [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=PPID 40 kDa peptidyl-prolyl cis-trans isomerase ENSG00000171497 IPI00003927 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=PPID Peptidyl-prolyl cis-trans isomerase D [EBI-IPI_Human_3.71_03-24-2010_reversed.fasta]
  • 40 kDa peptidyl-prolyl cis-trans isomerase [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q08752;B2R9V2; RecName: Full=Peptidyl-prolyl cis-trans isomerase D; AltName: Full=Rotamase D; AltName: Full=40 kDa peptidyl-prolyl cis-trans isomerase; AltName: Full=Cyclophilin-40; AltName: Full=Cyclophilin-related protein; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens GN=PPID [011711_HMR.fasta]
  • IPI:IPI00003927.5|SWISS-PROT:Q08752|TREMBL:Q05DH6;Q6FGM6|ENSEMBL:ENSP00000303754|REFSEQ:NP_005029|H-INV:HIT000041115 Tax_Id=9606 Gene_Symbol=PPID Peptidyl-prolyl cis-trans isomerase D [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=PPID Synonyms=CYP-40|CYPD|MGC33096 peptidyl-prolyl cis-trans isomerase D [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00003927.5|SWISS-PROT:Q08752|TREMBL:E5KN55;E5KN59;Q05DH6;Q6FGM6|ENSEMBL:ENSP00000303754|REFSEQ:NP_005029|H-INV:HIT000041115|VEGA:OTTHUMP00000220869 Tax_Id=9606 Gene_Symbol=PPID Peptidyl-prolyl cis-trans isomerase D [ipi.HUMAN.20110912.fasta]
  • Peptidyl-prolyl cis-trans isomerase D GN=PPID [Doctor+uniprot-HUMAN-120911.fasta]
  • Peptidyl-prolyl cis-trans isomerase D OS=Homo sapiens PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 370 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH  60
   61 TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM 120
  121 ANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGE KPAKLCVIAE 180
  181 CGELKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE 240
  241 MAIKKYAEVL RYVDSSKAVI ETADRAKLQP IALSCVLNIG ACKLKMSNWQ GAIDSCLEAL 300
  301 ELDPSNTKAL YRRAQGWQGL KEYDQALADL KKAQGIAPED KAIQAELLKV KQKIKAQKDK 360
  361 EKAVYAKMFA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..370] PSI-BLAST 56.69897 Cyclophilin 40; Cyclophilin 40 isomerase domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein deacetylase activity
    		•  4.3775483906311 bayes_pls_golite062009
  • histone deacetylase activity
    		•  4.29026678196473 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  3.73853378771688 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  3.66963215732405 bayes_pls_golite062009
  • deacetylase activity
    		•  3.49940864924766 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  3.01511519120932 bayes_pls_golite062009
  • RNA binding
    		•  2.94609837984526 bayes_pls_golite062009
  • signal sequence binding
    		•  2.68460419248567 bayes_pls_golite062009
  • isomerase activity
    		•  1.96529188741504 bayes_pls_golite062009
  • binding
    		•  1.65866393331484 bayes_pls_golite062009
  • mRNA binding
    		•  1.45537055700871 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.38124355054041 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.26149030245805 bayes_pls_golite062009
  • peroxisome targeting sequence binding
    		•  1.01220052237687 bayes_pls_golite062009
  • DNA binding
    		•  0.9531600253493 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.939772862764466 bayes_pls_golite062009
  • catalytic activity
    		•  0.748655649755714 bayes_pls_golite062009
  • hydrolase activity
    		•  0.493806105600863 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.408539130322443 bayes_pls_golite062009
  • transcription factor activity
    		•  0.374364600772076 bayes_pls_golite062009
  • drug binding
    		•  0.36339132904137 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.322244688184474 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.286133802341887 bayes_pls_golite062009
  • histone binding
    		•  0.268719695649015 bayes_pls_golite062009
  • protein binding
    		•  0.230077752280113 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  0.105969834846946 bayes_pls_golite062009
  • receptor binding
    		•  0.0640017685740477 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle