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Protein Overview: YWHAZ

General Information:
Name(s) found: YWHAZ [HGNC (HUGO)]
Description(s) found:
Found 76 descriptions.
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  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 245 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKNELVQKA KLAEQAERYD DMAACMKSVT EQGAELSNEE RNLLSVAYKN VVGARRSSWR  60
   61 VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL LEKFLIPNAS QAESKVFYLK 120
  121 MKGDYYRYLA EVAAGDDKKG IVDQSQQAYQ EAFEISKKEM QPTHPIRLGL ALNFSVFYYE 180
  181 ILNSPEKACS LAKTAFDEAI AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG 240
  241 EGGEN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..245] PSI-BLAST 112.0 Molecular basis for the recognition of phosphorylated and phosphoacetylated histone H3 by 14-3-3

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • tryptophan hydroxylase activator activity
    		•  9.05098057244127 bayes_pls_golite062009
  • protein kinase C inhibitor activity
    		•  5.16790132127192 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.42699469191586 bayes_pls_golite062009
  • actin binding
    		•  3.2102277095412 bayes_pls_golite062009
  • phosphoprotein phosphatase inhibitor activity
    		•  3.07610360813748 bayes_pls_golite062009
  • enzyme inhibitor activity
    		•  3.01719375125219 bayes_pls_golite062009
  • binding
    		•  2.865609797812 bayes_pls_golite062009
  • protein binding
    		•  2.70837661160137 bayes_pls_golite062009
  • phosphatase inhibitor activity
    		•  2.64873378059247 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  2.52034336284118 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.47421036599568 bayes_pls_golite062009
  • protein serine/threonine kinase inhibitor activity
    		•  2.26190206574987 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.24952329412422 bayes_pls_golite062009
  • protein kinase inhibitor activity
    		•  2.1605779239681 bayes_pls_golite062009
  • kinase inhibitor activity
    		•  2.13634503016902 bayes_pls_golite062009
  • DNA binding
    		•  2.12868741280915 bayes_pls_golite062009
  • enzyme regulator activity
    		•  2.06101279275497 bayes_pls_golite062009
  • receptor binding
    		•  1.90211144110648 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  1.89095665930248 bayes_pls_golite062009
  • kinase regulator activity
    		•  1.83999438696779 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  1.82791045779247 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.77196747521243 bayes_pls_golite062009
  • hormone receptor binding
    		•  1.75728917995967 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.58823136201189 bayes_pls_golite062009
  • transcription activator activity
    		•  1.55295513057402 bayes_pls_golite062009
  • enzyme binding
    		•  0.97087555033584 bayes_pls_golite062009
  • transcription factor binding
    		•  0.644366120007212 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.549856334651464 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.493085020732158 bayes_pls_golite062009
  • catalytic activity
    		•  0.260308151913118 bayes_pls_golite062009
  • glucocorticoid receptor binding
    		•  0.201948675373558 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.115610219048892 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle