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Protein Overview: SMC2_SCHPO

General Information:
Name(s) found: SMC2_SCHPO [Swiss-Prot]
Description(s) found:
Found 2 descriptions.
SHOW ALL
  • Structural maintenance of chromosomes protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cut14 PE=1 SV=2 [Swiss-Prot]
    • Organism: Schizosaccharomyces pombe 972h-
    Length: 1172 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKIEELIIDG FKSYAVRTVI SNWDDQFNAI TGLNGSGKSN ILDAICFVLG ITNMSTVRAQ  60
   61 NLQDLIYKRG QAGITRASVT IVFNNRDPAS SPIGFENHPQ VSVTRQIIMG GTSKYLINGH 120
  121 RALQQNVQNL FQSVQLNINN PNFLIMQGRI TKVLNMKATE ILSMIEEASG TRMFEERKEK 180
  181 AFRTMQRKEA KVEEINTLLR EEIEPRLTKL RTEKKTFLEY QHIYNDLERL SHLCTAYDYY 240
  241 KLSLKVEELT VQASQKHSHI AEMESSLQTS KQEVLILKEK IKKIEDERMR QMSVSSDRTL 300
  301 DSQLQTVNEN ITRISTSIEL KNTALEEEHG DLQQIRGKAK ELETLLRGKR KRLDEVLSVY 360
  361 EKRKDEHQSI SKDFKSQEEL ISSLTTGLST TEGHETGYSR KLHEARDTLN DFKAEKETNR 420
  421 LKLEGLNKQI SLTKPKKAEA TKRCDQLNRE IDILQNHVEK LKMSLKNTNS DITGEDVLQQ 480
  481 KLKQLAKDRG NLLNELDALK SKLAYMEFTY TDPTPNFDRS KVKGLVAQLL TLNEENYDKQ 540
  541 TALEITAGGR LYNLIVETEK IGAQLLQKGN LKRRVTIIPL NKITSFVASA ERVGAAKKIS 600
  601 NNKAQLALEL IGYDDELLPA MQYVFGSTLV CDTPESAKKV TFHPSVKLKS VTLDGDVYDP 660
  661 SGTLTGGSVN KSAGPLLQIQ KLNSLQLKLQ VVTSEYEKLE TQLKDLKTQN ANFHRLEQEI 720
  721 QLKQHELTLL IEQRETDSSF RLLSDYQQYK DDVKDLKQRL PELDRLILQS DQAIKKIERD 780
  781 MQEWKHNKGS KMAELEKEFN QYKHKLDEFT PILEKSENDY NGVKLECEQL EGELQNHQQS 840
  841 LVQGESTTSL IKTEIAELEL SLVNEEHNRK KLTELIEIES AKFSGLNKEI DSLSTSMKTF 900
  901 ESEINNGELT IQKLNHEFDR LEREKSVAIT AINHLEKEND WIDGQKQHFG KQGTIFDFHS 960
  961 QNMRQCREQL HNLKPRFASM RKAINPKVMD MIDGVEKKEA KLRSMIKTIH RDKKKIQDTV1020
 1021 KSIDRFKRSA LEKTWREVNS SFGEIFDELL PGNSAELQPP ENKEFTDGLE IHVKIGSIWK1080
 1081 DSLAELSGGQ RSLVALALIM SLLKYKPAPM YILDEIDAAL DLSHTQNIGR LIKTKFKGSQ1140
 1141 FIIVSLKEGM FTNANRLFHV RFMDGSSVVQ AR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..172] PSI-BLAST 37.69897 Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.
    2 View Details [173..502] FFAS03 2.76 Tropomyosin
    3 View Details [503..723] FFAS03 4.73 Smc hinge domain
    4 View Details [724..1014] deduced N/A No confident structure predictions are available.
    5 View Details [1015..1172] PSI-BLAST 17.39794 Structural biochemistry of ATP-driven dimerization and DNA stimulated activation of SMC ATPases.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA clamp loader activity
    		•  3.69872504333327 bayes_pls_golite062009
  • motor activity
    		•  2.79327761685782 bayes_pls_golite062009
  • microtubule motor activity
    		•  2.74365461017633 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.69246499202248 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.61582393123755 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.59641929642359 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.59333672868803 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.58390156971125 bayes_pls_golite062009
  • binding
    		•  2.4974940028864 bayes_pls_golite062009
  • transporter activity
    		•  2.17383908004663 bayes_pls_golite062009
  • ATPase activity
    		•  2.11122403732968 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.02444700826552 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.8908019270286 bayes_pls_golite062009
  • DNA helicase activity
    		•  1.72320119360938 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.52935820732225 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.40488517180956 bayes_pls_golite062009
  • hydrolase activity
    		•  1.35268825531078 bayes_pls_golite062009
  • helicase activity
    		•  1.33212695797068 bayes_pls_golite062009
  • tubulin binding
    		•  0.979946830272106 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.97700154207756 bayes_pls_golite062009
  • microtubule binding
    		•  0.907162506177187 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.89390151223569 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.89390151223569 bayes_pls_golite062009
  • actin binding
    		•  0.883285269827407 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  0.654899784430321 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.608058786636536 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.579644950922817 bayes_pls_golite062009
  • kinetochore binding
    		•  0.534490088080411 bayes_pls_golite062009
  • catalytic activity
    		•  0.458437698837681 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • protein binding
    		•  0.378225828131122 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.322818640526369 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.2192434828134 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • dynein binding
    		•  0.150959629961177 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.10236059675512 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.081265446432119 bayes_pls_golite062009
  • recombinase activity
    		•  0.0490751527151101 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.7707163143035 bayes_pls_golite062009
  • protein binding
    		•  1.2343536336523 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.56283355879326 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.511272811276509 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.299763949828861 bayes_pls_golite062009
  • DNA secondary structure binding
    		•  0.284996962785104 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.248383422632029 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.235472660839816 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.233111707634177 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.210107708818734 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.155323194767055 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.101477244722795 bayes_pls_golite062009
  • ATPase activity
    		•  0.08869715759545 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle