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Protein Overview: METAP2

General Information:
Name(s) found: METAP2 [HGNC (HUGO)]
Description(s) found:
Found 44 descriptions.
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  • methionyl aminopeptidase 2 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 478 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAGVEEVAAS GSHLNGDLDP DDREEGAAST AEEAAKKKRR KKKKSKGPSA AGEQEPDKES  60
   61 GASVDEVARQ LERSALEDKE RDEDDEDGDG DGDGATGKKK KKKKKKRGPK VQTDPPSVPI 120
  121 CDLYPNGVFP KGQECEYPPT QDGRTAAWRT TSEEKKALDQ ASEEIWNDFR EAAEAHRQVR 180
  181 KYVMSWIKPG MTMIEICEKL EDCSRKLIKE NGLNAGLAFP TGCSLNNCAA HYTPNAGDTT 240
  241 VLQYDDICKI DFGTHISGRI IDCAFTVTFN PKYDTLLKAV KDATNTGIKC AGIDVRLCDV 300
  301 GEAIQEVMES YEVEIDGKTY QVKPIRNLNG HSIGQYRIHA GKTVPIVKGG EATRMEEGEV 360
  361 YAIETFGSTG KGVVHDDMEC SHYMKNFDVG HVPIRLPRTK HLLNVINENF GTLAFCRRWL 420
  421 DRLGESKYLM ALKNLCDLGI VDPYPPLCDI KGSYTAQFEH TILLRPTCKE VVSRGDDY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..478] PSI-BLAST 139.0 HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH TNP-470

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  2.60615909541559 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.18503136472662 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.8401324043677 bayes_pls_golite062009
  • transcription activator activity
    		•  1.69071209162619 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.54960543048317 bayes_pls_golite062009
  • hydrolase activity
    		•  1.43646476372001 bayes_pls_golite062009
  • binding
    		•  1.30837875079167 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.07337728528324 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.0361110104194 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.977875027333104 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.89399203910285 bayes_pls_golite062009
  • DNA binding
    		•  0.772721556221145 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.762255574851485 bayes_pls_golite062009
  • metallopeptidase activity
    		•  0.629480947971878 bayes_pls_golite062009
  • protein binding
    		•  0.378185804009078 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.278734480962003 bayes_pls_golite062009
  • structural molecule activity
    		•  0.276811112308517 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.249771970501337 bayes_pls_golite062009
  • catalytic activity
    		•  0.148551873544128 bayes_pls_golite062009
  • transcription factor activity
    		•  0.143705860811928 bayes_pls_golite062009
  • transcription factor binding
    		•  0.13558561552621 bayes_pls_golite062009
  • transferase activity
    		•  0.064832527337659 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle