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Protein Overview: TSG101

General Information:
Name(s) found: TSG101 [HGNC (HUGO)]
Description(s) found:
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  • gi|9789790|sp|Q99816.2|TS101_HUMAN RecName: Full=Tumor susceptibility gene 101 protein; AltName: Full=ESCRT-I complex subunit TSG101 [NCBI NR]
  • gi|5454140|ref|NP_006283.1| tumor susceptibility gene 101 [Homo sapiens] [NCBI NR]
  • gi|3184258|gb|AAC52083.1| tumor susceptibility protein [Homo sapiens] [NCBI NR]
  • gi|119588791|gb|EAW68385.1| tumor susceptibility gene 101, isoform CRA_d [Homo sapiens] [NCBI NR]
  • tumor susceptibility gene 101 [HGNC (HUGO)]
  • Tumor susceptibility gene 101 protein OS=Homo sapiens GN=TSG101 PE=1 SV=2 [Swiss-Prot]
  • (Q99816) Tumor susceptibility gene 101 protein [Swiss-Prot]
  • Splice isoform 1 of Q99816 [hmr_yeast5_DM3-1_pombe.fasta]
  • tumor susceptibility gene 101 [Homo sapiens]gi|3184258|gb|AAC52083.1| tumor susceptibility protein [Homo sapiens]gi|9789790|sp|Q99816|T101_HUMAN Tumor susceptibility gene 101 protein [nrdb_11152004_Chlamydomonas]
  • Tumor susceptibility gene 101 protein [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Splice Isoform 1 of Tumor susceptibility gene 101 protein [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_006292) tumor susceptibility gene 101 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • tumor susceptibility gene 101 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • tumor susceptibility gene 101, isoform CRA_d [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • tumor susceptibility protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of Tumor susceptibility gene 101 protein [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 SPLICE ISOFORM 1 OF TUMOR SUSCEPTIBILITY GENE 101 PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Tumor susceptibility gene 101 protein [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=TSG101 Isoform 1 of Tumor susceptibility gene 101 protein [human-ipi-250309-contam.fasta]
  • IPI:IPI00018434.1|SWISS-PROT:Q99816-1|ENSEMBL:ENSP00000251968|REFSEQ:NP_006283|H-INV:HIT000284093 Tax_Id=9606 Gene_Symbol=TSG101 Isoform 1 of Tumor susceptibility gene 101 protein [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=TSG101 Isoform 1 of Tumor susceptibility gene 101 protein ENSG00000074319 IPI00018434 IPI00219826 IPI00383946 [drosphohumanreversed.fasta]
  • tumor susceptibility gene 101 protein [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q99816;Q9BUM5; RecName: Full=Tumor susceptibility gene 101 protein; AltName: Full=ESCRT-I complex subunit TSG101; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Tumor susceptibility gene 101 protein OS=Homo sapiens GN=TSG101 [011711_HMR.fasta]
  • GeneSymbol=TSG101 Synonyms=TSG10|VPS23 tumor susceptibility gene 101 protein [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00018434.1|SWISS-PROT:Q99816-1|ENSEMBL:ENSP00000251968|REFSEQ:NP_006283|H-INV:HIT000284093|VEGA:OTTHUMP00000236662 Tax_Id=9606 Gene_Symbol=TSG101 Isoform 1 of Tumor susceptibility gene 101 protein [ipi.HUMAN.20110912.fasta]
  • Tumor susceptibility gene 101 protein GN=TSG101 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 390 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVSESQLKK MVSKYKYRDL TVRETVNVIT LYKDLKPVLD SYVFNDGSSR ELMNLTGTIP  60
   61 VPYRGNTYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG KHVDANGKIY LPYLHEWKHP 120
  121 QSDLLGLIQV MIVVFGDEPP VFSRPISASY PPYQATGPPN TSYMPGMPGG ISPYPSGYPP 180
  181 NPSGYPGCPY PPGGPYPATT SSQYPSQPPV TTVGPSRDGT ISEDTIRASL ISAVSDKLRW 240
  241 RMKEEMDRAQ AELNALKRTE EDLKKGHQKL EEMVTRLDQE VAEVDKNIEL LKKKDEELSS 300
  301 ALEKMENQSE NNDIDEVIIP TAPLYKQILN LYAEENAIED TIFYLGEALR RGVIDLDVFL 360
  361 KHVRLLSRKQ FQLRALMQKA RKTAGLSDLY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..194] PSI-BLAST 46.39794 Tumor susceptibility gene 101 (TSG101) UEV domain
    2 View Details [195..390] PSI-BLAST 23.522879 Heavy meromyosin subfragment

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • small conjugating protein ligase activity
    		•  6.80727357703118 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  6.75330204125607 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  5.83782824833863 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  3.8110076681004 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21355731489173 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13970605403492 bayes_pls_golite062009
  • DNA binding
    		•  1.95596447916631 bayes_pls_golite062009
  • ligase activity
    		•  1.88059319399119 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.5236035191291 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • SUMO ligase activity
    		•  0.843488104298821 bayes_pls_golite062009
  • protein binding
    		•  0.726328463755484 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  0.715654744941217 bayes_pls_golite062009
  • protein kinase activity
    		•  0.443948654247666 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.182854082413338 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.133142640608253 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.122859425935324 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0501858755083694 bayes_pls_golite062009
  • kinase activity
    		•  0.0500350353657541 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0138208971172455 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0104967529560147 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle