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Protein Overview: AMFR

General Information:
Name(s) found: AMFR [HGNC (HUGO)]
Description(s) found:
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  • gi|46623045|gb|AAH69197.1| Autocrine motility factor receptor [Homo sapiens] [NCBI NR]
  • gi|34922250|sp|Q9UKV5.2|AMFR2_HUMAN RecName: Full=Autocrine motility factor receptor, isoform 2; Short=AMF receptor, isoform 2; AltName: Full=gp78; AltName: Full=RING finger protein 45 [NCBI NR]
  • gi|21071001|ref|NP_001135.3| autocrine motility factor receptor [Homo sapiens] [NCBI NR]
  • autocrine motility factor receptor [HGNC (HUGO)]
  • E3 ubiquitin-protein ligase AMFR OS=Homo sapiens GN=AMFR PE=1 SV=2 [Swiss-Prot]
  • (Q9UKV5) Autocrine motility factor receptor, isoform 2 (EC 6.3.2.-) (AMF receptor) (gp78) [Swiss-Prot]
  • Autocrine motility factor receptor, isoform 2 [hmr_yeast5_DM3-1_pombe.fasta]
  • autocrine motility factor receptor isoform a [HMR_022704.fasta]
  • autocrine motility factor receptor isoform a [Homo sapiens]gi|46623045|gb|AAH69197.1| Autocrine motility factor receptor, isoform a [Homo sapiens]gi|34922250|sp|Q9UKV5|AMF2_HUMAN Autocrine motility factor receptor, isoform 2 (AMF receptor) (gp78) [nrdb_11152004_Chlamydomonas]
  • Autocrine motility factor receptor, isoform 2 (AMF receptor) (gp78) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Autocrine motility factor receptor, isoform 2 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_001144) autocrine motility factor receptor, isoform a [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • autocrine motility factor receptor [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • autocrine motility factor receptor isoform a [Homo sapiens] [HumanGallus06162005.fasta]
  • Autocrine motility factor receptor, isoform 2 (AMF receptor) (gp78) (RING finger protein 45) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Autocrine motility factor receptor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 AUTOCRINE MOTILITY FACTOR RECEPTOR, ISOFORM 2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=AMFR Autocrine motility factor receptor, isoform 2 [human-ipi-250309-contam.fasta]
  • IPI:IPI00423874.1|SWISS-PROT:Q9UKV5|TREMBL:Q1RN03|ENSEMBL:ENSP00000290649|REFSEQ:NP_001135|H-INV:HIT000263357|VEGA:OTTHUMP00000080136;OTTHUMP00000164316 Tax_Id=9606 Gene_Symbol=AMFR Autocrine motility factor receptor, isoform 2 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=AMFR Autocrine motility factor receptor, isoform 2 ENSG00000159461 IPI00423874 IPI00435690 IPI00376686 IPI00640753 [drosphohumanreversed.fasta]
  • autocrine motility factor receptor, isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Autocrine motility factor receptor, isoform 2 OS=Homo sapiens GN=AMFR PE=1 SV=2 [UniProtHuman070710.fasta]
  • Q9UKV5;Q8IZ70; RecName: Full=Autocrine motility factor receptor, isoform 2; AltName: Full=gp78; AltName: Full=RING finger protein 45; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 2 of E3 ubiquitin-protein ligase AMFR OS=Homo sapiens GN=AMFR [011711_HMR.fasta]
  • GeneSymbol=AMFR Synonyms=GP78|RNF45 autocrine motility factor receptor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00423874.1|SWISS-PROT:Q9UKV5|TREMBL:Q1RN03|ENSEMBL:ENSP00000290649|REFSEQ:NP_001135|H-INV:HIT000263357|VEGA:OTTHUMP00000164316 Tax_Id=9606 Gene_Symbol=AMFR E3 ubiquitin-protein ligase AMFR [ipi.HUMAN.20110912.fasta]
  • E3 ubiquitin-protein ligase AMFR GN=AMFR [Doctor+uniprot-HUMAN-120911.fasta]
  • Tax_Id=9606 Gene_Symbol=AMFR E3 ubiquitin-protein ligase AMFR [human-ipi-270911-contam-BSA.fasta]
    • Organism: Homo sapiens
    Length: 643 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLLFLERFP WPSLRTYTGL SGLALLGTII SAYRALSQPE AGPGEPDQLT ASLQPEPPAP  60
   61 ARPSAGGPRA RDVAQYLLSD SLFVWVLVNT ACCVLMLVAK LIQCIVFGPL RVSERQHLKD 120
  121 KFWNFIFYKF IFIFGVLNVQ TVEEVVMWCL WFAGLVFLHL MVQLCKDRFE YLSFSPTTPM 180
  181 SSHGRVLSLL VAMLLSCCGL AAVCSITGYT HGMHTLAFMA AESLLVTVRT AHVILRYVIH 240
  241 LWDLNHEGTW EGKGTYVYYT DFVMELTLLS LDLMHHIHML LFGNIWLSMA SLVIFMQLRY 300
  301 LFHEVQRRIR RHKNYLRVVG NMEARFAVAT PEELAVNNDD CAICWDSMQA ARKLPCGHLF 360
  361 HNSCLRSWLE QDTSCPTCRM SLNIADNNRV REEHQGENLD ENLVPVAAAE GRPRLNQHNH 420
  421 FFHFDGSRIA SWLPSFSVEV MHTTNILGIT QASNSQLNAM AHQIQEMFPQ VPYHLVLQDL 480
  481 QLTRSVEITT DNILEGRIQV PFPTQRSDSI RPALNSPVER PSSDQEEGET SAQTERVPLD 540
  541 LSPRLEETLD FGEVEVEPSE VEDFEARGSR FSKSADERQR MLVQRKDELL QQARKRFLNK 600
  601 SSEDDAASES FLPSEGASSD PVTLRRRMLA AAAERRLQKQ QTS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..134] deduced N/A No confident structure predictions are available.
    2 View Details [135..401] PSI-BLAST 24.39794 Cbl; N-terminal domain of cbl (N-cbl); CBL
    3 View Details [402..495] FFAS03 3.15 No description for 2ekfA was found.
    4 View Details [496..643] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • molecular transducer activity
    		•  3.58651960433016 bayes_pls_golite062009
  • signal transducer activity
    		•  3.58651960433016 bayes_pls_golite062009
  • binding
    		•  3.12724619324809 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.53071837898279 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  2.35007226898734 bayes_pls_golite062009
  • protein binding
    		•  2.14586566310919 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.60687631865164 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  1.37401357060257 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • calcium ion binding
    		•  1.03474411638676 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • receptor binding
    		•  1.02111138016453 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.998938018700239 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • S100 alpha binding
    		•  0.695694593922059 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.540818657754841 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.53070890116366 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.476094076158571 bayes_pls_golite062009
  • protein kinase activity
    		•  0.373245013550244 bayes_pls_golite062009
  • hydrolase activity
    		•  0.365893102981186 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.293268642733772 bayes_pls_golite062009
  • DNA binding
    		•  0.281643350069021 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.27738240687034 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.23313435855689 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.205769810664775 bayes_pls_golite062009
  • channel activity
    		•  0.205769810664775 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.202021526297279 bayes_pls_golite062009
  • kinase activity
    		•  0.193243470329802 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.182737303659095 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.16976955164497 bayes_pls_golite062009
  • ion channel activity
    		•  0.0949210510895822 bayes_pls_golite062009
  • gated channel activity
    		•  0.0709126830279607 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.0099972847734251 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle