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Protein Overview: SLC25A13

General Information:
Name(s) found: SLC25A13 [HGNC (HUGO)]
Description(s) found:
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  • gi|7657581|ref|NP_055066.1| solute carrier family 25, member 13 isoform 2 [Homo sapiens] [NCBI NR]
  • gi|5052319|gb|AAD38501.1|AF118838_1 citrin; adult-onset type II citrullinemia protein [Homo sapiens] [NCBI NR]
  • gi|16306895|gb|AAH06566.1| Solute carrier family 25, member 13 (citrin) [Homo sapiens] [NCBI NR]
  • gi|13124095|sp|Q9UJS0.2|CMC2_HUMAN RecName: Full=Calcium-binding mitochondrial carrier protein Aralar2; AltName: Full=Mitochondrial aspartate glutamate carrier 2; AltName: Full=Solute carrier family 25 member 13; AltName: Full=Citrin [NCBI NR]
  • gi|119597155|gb|EAW76749.1| solute carrier family 25, member 13 (citrin), isoform CRA_b [Homo sapiens] [NCBI NR]
  • solute carrier family 25, member 13 (citrin) [HGNC (HUGO)]
  • Calcium-binding mitochondrial carrier protein Aralar2 OS=Homo sapiens GN=SLC25A13 PE=1 SV=2 [Swiss-Prot]
  • Calcium-binding mitochondrial carrier protein Aralar2 [hmr_yeast5_DM3-1_pombe.fasta]
  • solute carrier family 25, member 13 (citrin) [Homo sapiens]gi|16306895|gb|AAH06566.1| Solute carrier family 25, member 13 (citrin) [Homo sapiens]gi|13124095|sp|Q9UJS0|CMC2_HUMAN Calcium-binding mitochondrial carrier protein Aralar2 (Mitochondrial aspart [nrdb_11152004_Chlamydomonas]
  • Calcium-binding mitochondrial carrier protein Aralar2 (Mitochondrial aspartate glutamate carrier 2) (Solute carrier family 25 member 13) (Citrin) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • (NM_014251) solute carrier family 25, member 13 (citrin) [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • solute carrier family 25, member 13 (citrin) [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Calcium-binding mitochondrial carrier protein Aralar2 [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • solute carrier family 25, member 13 (citrin), isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Solute carrier family 25, member 13 (citrin) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • citrin; adult-onset type II citrullinemia protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Calcium-binding mitochondrial carrier protein Aralar2; AltName: Full=Mitochondrial aspartate glutamate carrier 2; AltName: Full=Solute carrier family 25 member 13; AltName: Full=Citrin [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • solute carrier family 25, member 13 isoform 2 [Homo sapiens] [NCBI-RefSeq_human_na_07-13-2009_con_reversed.fasta]
  • IPI:IPI00007084.3|SWISS-PROT:Q9UJS0|TREMBL:B7Z2E2;Q53GR7;Q75KX8;Q75M55|ENSEMBL:ENSP00000265631|REFSEQ:NP_055066|H-INV:HIT000070188|VEGA:OTTHUMP00000024692 Tax_Id=9606 Gene_Symbol=SLC25A13 Calcium-binding mitochondrial carrier protein Aralar2 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=SLC25A13 Calcium-binding mitochondrial carrier protein Aralar2 [EBI-IPI_Human_3.71_03-24-2010_reversed.fasta]
  • Q9UJS0;O14566;O14575;Q9NZW1;Q9UNI7; RecName: Full=Calcium-binding mitochondrial carrier protein Aralar2; AltName: Full=Mitochondrial aspartate glutamate carrier 2; AltName: Full=Solute carrier family 25 member 13; AltName: Full=Citrin; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Calcium-binding mitochondrial carrier protein Aralar2 OS=Homo sapiens GN=SLC25A13 [011711_HMR.fasta]
  • GeneSymbol=SLC25A13 Synonyms=ARALAR2|CITRIN|CTLN2 calcium-binding mitochondrial carrier protein Aralar2 isoform 2 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Calcium-binding mitochondrial carrier protein Aralar2 GN=SLC25A13 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 675 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAKVALTK RADPAELRTI FLKYASIEKN GEFFMSPNDF VTRYLNIFGE SQPNPKTVEL  60
   61 LSGVVDQTKD GLISFQEFVA FESVLCAPDA LFMVAFQLFD KAGKGEVTFE DVKQVFGQTT 120
  121 IHQHIPFNWD SEFVQLHFGK ERKRHLTYAE FTQFLLEIQL EHAKQAFVQR DNARTGRVTA 180
  181 IDFRDIMVTI RPHVLTPFVE ECLVAAAGGT TSHQVSFSYF NGFNSLLNNM ELIRKIYSTL 240
  241 AGTRKDVEVT KEEFVLAAQK FGQVTPMEVD ILFQLADLYE PRGRMTLADI ERIAPLEEGT 300
  301 LPFNLAEAQR QKASGDSARP VLLQVAESAY RFGLGSVAGA VGATAVYPID LVKTRMQNQR 360
  361 STGSFVGELM YKNSFDCFKK VLRYEGFFGL YRGLLPQLLG VAPEKAIKLT VNDFVRDKFM 420
  421 HKDGSVPLAA EILAGGCAGG SQVIFTNPLE IVKIRLQVAG EITTGPRVSA LSVVRDLGFF 480
  481 GIYKGAKACF LRDIPFSAIY FPCYAHVKAS FANEDGQVSP GSLLLAGAIA GMPAASLVTP 540
  541 ADVIKTRLQV AARAGQTTYS GVIDCFRKIL REEGPKALWK GAGARVFRSS PQFGVTLLTY 600
  601 ELLQRWFYID FGGVKPMGSE PVPKSRINLP APNPDHVGGY KLAVATFAGI ENKFGLYLPL 660
  661 FKPSVSTSKA IGGGP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered Sample pIC146 from april 2005 Okada, M., et al. (2006)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] PSI-BLAST 45.30103 No description for 1zuzA was found.
    2 View Details [172..318] FFAS03 4.52 Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
    3 View Details [319..675] PSI-BLAST 83.221849 structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • calcium ion binding
    		•  3.79609619542776 bayes_pls_golite062009
  • binding
    		•  2.74623080162785 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.61874575467092 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.57032504567157 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.55650624542181 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37465721152046 bayes_pls_golite062009
  • potassium channel activity
    		•  1.89948827776974 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  1.81135503818602 bayes_pls_golite062009
  • cation channel activity
    		•  1.49312394054212 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.38521870126745 bayes_pls_golite062009
  • signal transducer activity
    		•  1.38521870126745 bayes_pls_golite062009
  • ion binding
    		•  1.36376383271837 bayes_pls_golite062009
  • cation binding
    		•  1.34827363853601 bayes_pls_golite062009
  • metal ion binding
    		•  1.34827363853601 bayes_pls_golite062009
  • structural molecule activity
    		•  1.26857768455914 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.22886396511326 bayes_pls_golite062009
  • protein binding
    		•  1.16246005294206 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • channel activity
    		•  1.05847414989139 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.05847414989139 bayes_pls_golite062009
  • ion channel activity
    		•  1.0369591011376 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.03529144716694 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.986621437232479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.910148857310729 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.896351900356978 bayes_pls_golite062009
  • gated channel activity
    		•  0.855502499003241 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.849623084382492 bayes_pls_golite062009
  • DNA binding
    		•  0.81633153359201 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.75057755360417 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  0.717054504236607 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
    		• 0.34446792626966 bayes_pls_golite062009
  • channel regulator activity
    		•  0.32809521759917 bayes_pls_golite062009
  • protein complex binding
    		•  0.278602833762221 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.23313435855689 bayes_pls_golite062009
  • motor activity
    		•  0.0886596083402598 bayes_pls_golite062009
  • transcription factor binding
    		•  0.02456682442567 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.67

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle