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Protein Overview: RNF14

General Information:
Name(s) found: RNF14 [HGNC (HUGO)]
Description(s) found:
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  • gi|5019618|dbj|BAA78677.1| HFB30 [Homo sapiens] [NCBI NR]
  • gi|4757762|ref|NP_004281.1| ring finger protein 14 isoform 1 [Homo sapiens] [NCBI NR]
  • gi|4530066|gb|AAD21842.1| androgen receptor associated protein 54 [Homo sapiens] [NCBI NR]
  • gi|34577102|ref|NP_899648.1| ring finger protein 14 isoform 1 [Homo sapiens] [NCBI NR]
  • gi|34577100|ref|NP_899647.1| ring finger protein 14 isoform 1 [Homo sapiens] [NCBI NR]
  • gi|34577098|ref|NP_899646.1| ring finger protein 14 isoform 1 [Homo sapiens] [NCBI NR]
  • gi|219518121|gb|AAI44062.1| Ring finger protein 14 [Homo sapiens] [NCBI NR]
  • gi|193785799|dbj|BAG51234.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|17380293|sp|Q9UBS8.1|RNF14_HUMAN RecName: Full=E3 ubiquitin-protein ligase RNF14; AltName: Full=RING finger protein 14; AltName: Full=Androgen receptor-associated protein 54; AltName: Full=Triad2 protein; AltName: Full=HFB30 [NCBI NR]
  • gi|119582301|gb|EAW61897.1| ring finger protein 14, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119582300|gb|EAW61896.1| ring finger protein 14, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119582299|gb|EAW61895.1| ring finger protein 14, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119582298|gb|EAW61894.1| ring finger protein 14, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|116496825|gb|AAI26186.1| Ring finger protein 14 [Homo sapiens] [NCBI NR]
  • ring finger protein 14 [HGNC (HUGO)]
  • E3 ubiquitin-protein ligase RNF14 OS=Homo sapiens GN=RNF14 PE=1 SV=1 [Swiss-Prot]
  • (Q9UBS8) RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein) (HFB30) (HRIHFB2038) [Swiss-Prot]
  • RING finger protein 14 [hmr_yeast5_DM3-1_pombe.fasta]
  • ring finger protein 14 isoform 1; androgen receptor associated protein 54; triad2 protein [HMR_022704.fasta]
  • ring finger protein 14 isoform 1 [Homo sapiens]gi|34577100|ref|NP_899647.1| ring finger protein 14 isoform 1 [Homo sapiens]gi|34577098|ref|NP_899646.1| ring finger protein 14 isoform 1 [Homo sapiens]gi|4757762|ref|NP_004281.1| ring finger protein 14 is [nrdb_11152004_Chlamydomonas]
  • RING finger protein 14 (Androgen receptor-associated protein 54) (Triad2 protein) (HFB30) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 RING finger protein 14 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_004290) ring finger protein 14; androgen receptor associated protein 54 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • ring finger protein 14 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • ring finger protein 14 isoform 1; androgen receptor associated protein 54; triad2 protein [Homo sapiens] [HumanGallus06162005.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • E3 ubiquitin-protein ligase RNF14 (RING finger protein 14) (Androgen receptor-associated protein 54) (Triad2 protein) (HFB30) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ring finger protein 14, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Ring finger protein 14 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • HFB30 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • androgen receptor associated protein 54 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 RING FINGER PROTEIN 14 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=E3 ubiquitin-protein ligase RNF14; AltName: Full=RING finger protein 14; AltName: Full=Androgen receptor-associated protein 54; AltName: Full=Triad2 protein; AltName: Full=HFB30 [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=RNF14 E3 ubiquitin-protein ligase RNF14 [human-ipi-250309-contam.fasta]
  • IPI:IPI00003606.3|SWISS-PROT:Q9UBS8|TREMBL:B3KN55;B7ZLV2|ENSEMBL:ENSP00000324956;ENSP00000348462;ENSP00000378027;ENSP00000378028|REFSEQ:NP_004281;NP_899646;NP_899647;NP_899648|H-INV:HIT000388777|VEGA:OTTHUMP00000160065 Tax_Id=9606 Gene_Symbol=RNF14 E3 ubi [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 E3 ubiquitin-protein ligase RNF14 [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=RNF14 E3 ubiquitin-protein ligase RNF14 ENSG00000013561 IPI00374140 IPI00003606 [drosphohumanreversed.fasta]
  • E3 ubiquitin-protein ligase RNF14 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q9UBS8;A0AV26;A6NMR2;B3KN72;B7ZLV2;O94793;Q6IBV0; RecName: Full=E3 ubiquitin-protein ligase RNF14; AltName: Full=RING finger protein 14; AltName: Full=Androgen receptor-associated protein 54; AltName: Full=Triad2 protein; AltName: Full=HFB30; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • E3 ubiquitin-protein ligase RNF14 OS=Homo sapiens GN=RNF14 [011711_HMR.fasta]
  • IPI:IPI00003606.3|SWISS-PROT:Q9UBS8|TREMBL:B3KN55;D3DQE4|ENSEMBL:ENSP00000324956;ENSP00000348462;ENSP00000378027;ENSP00000378028|REFSEQ:NP_004281;NP_899646;NP_899647;NP_899648|H-INV:HIT000388777|VEGA:OTTHUMP00000160065 Tax_Id=9606 Gene_Symbol=RNF14 E3 ubiquitin-protein ligase RNF14 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=RNF14 Synonyms=ARA54|FLJ26004|HFB30|TRIAD2 E3 ubiquitin-protein ligase RNF14 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00003606.3|SWISS-PROT:Q9UBS8|TREMBL:B3KN55|ENSEMBL:ENSP00000324956;ENSP00000348462;ENSP00000378027;ENSP00000378028|REFSEQ:NP_001188294;NP_004281;NP_899646;NP_899647;NP_899648|H-INV:HIT000388777|VEGA:OTTHUMP00000160065 Tax_Id=9606 Gene_Symbol=RNF14 E3 ubiquitin-protein ligase RNF14 [ipi.HUMAN.20110912.fasta]
  • E3 ubiquitin-protein ligase RNF14 GN=RNF14 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 474 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEDREAQE DELLALASIY DGDEFRKAES VQGGETRIYL DLPQNFKIFV SGNSNECLQN  60
   61 SGFEYTICFL PPLVLNFELP PDYPSSSPPS FTLSGKWLSP TQLSALCKHL DNLWEEHRGS 120
  121 VVLFAWMQFL KEETLAYLNI VSPFELKIGS QKKVQRRTAQ ASPNTELDFG GAAGSDVDQE 180
  181 EIVDERAVQD VESLSNLIQE ILDFDQAQQI KCFNSKLFLC SICFCEKLGS ECMYFLECRH 240
  241 VYCKACLKDY FEIQIRDGQV QCLNCPEPKC PSVATPGQVK ELVEAELFAR YDRLLLQSSL 300
  301 DLMADVVYCP RPCCQLPVMQ EPGCTMGICS SCNFAFCTLC RLTYHGVSPC KVTAEKLMDL 360
  361 RNEYLQADEA NKRLLDQRYG KRVIQKALEE MESKEWLEKN SKSCPCCGTP IEKLDGCNKM 420
  421 TCTGCMQYFC WICMGSLSRA NPYKHFNDPG SPCFNRLFYA VDVDDDIWED EVED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..214] PSI-BLAST 22.522879 No description for 2ebmA was found.
    2 View Details [215..303] PSI-BLAST 7.0 Solution Structure of the RING finger Domain of the human UbcM4-interacting Protein 4
    3 View Details [304..384] PSI-BLAST 3.39794 No description for 2jmoA was found.
    4 View Details [385..474] PSI-BLAST 11.0 Solution Structure of the C-terminal RING from a RING-IBR-RING (TRIAD) motif

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  5.97121728620188 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  5.78935175140238 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.75377804653841 bayes_pls_golite062009
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.72498741013971 bayes_pls_golite062009
  • protein binding
    		•  2.64803540957326 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.57382484274962 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.32387297115017 bayes_pls_golite062009
  • DNA binding
    		•  2.00904221080834 bayes_pls_golite062009
  • transcription activator activity
    		•  1.45530270292081 bayes_pls_golite062009
  • ligase activity
    		•  1.28164271879607 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22579085356684 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • transcription factor binding
    		•  1.11842175076436 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.926364718530146 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.90321253993065 bayes_pls_golite062009
  • hydrolase activity
    		•  0.52386813728704 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.350170315296021 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.24963159801049 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.233838999434784 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  5.97121728620188 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  5.78935175140238 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.75377804653841 bayes_pls_golite062009
  • binding
    		•  2.78710909602478 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.72498741013971 bayes_pls_golite062009
  • protein binding
    		•  2.64803540957326 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.57382484274962 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.32387297115017 bayes_pls_golite062009
  • DNA binding
    		•  2.00904221080834 bayes_pls_golite062009
  • transcription activator activity
    		•  1.45530270292081 bayes_pls_golite062009
  • ligase activity
    		•  1.28164271879607 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22579085356684 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  1.2126425713931 bayes_pls_golite062009
  • transcription factor binding
    		•  1.11842175076436 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  1.03469202541773 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.926364718530146 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.90321253993065 bayes_pls_golite062009
  • hydrolase activity
    		•  0.52386813728704 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  0.50197530717959 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.350170315296021 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  0.265769062717221 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.24963159801049 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.233838999434784 bayes_pls_golite062009
  • catalytic activity
    		•  0.14112008370434 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle