YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: RNF14
Organism: Homo sapiens
Length: 474 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RNF14.

Description E-value Query
Range		 Subject
Range
gi|114602433 - gi|114602433|ref|XP_001152699.1| PREDICTED: ring finger protein 14 isoform 8 [Pan troglodytes]
 8.0E-91 [1..474] [53..526]
gi|48145521 - gi|48145521|emb|CAG32983.1| RNF14 [Homo sapiens]
 3.0E-89 [1..474] [1..474]
gi|197097758 - gi|197097758|ref|NP_001125890.1| ring finger protein 14 [Pongo abelii]
gi|55729565 - gi|55729565|emb|CAH91513.1| hypothetical protein [Pongo abelii]
 6.0E-89 [1..474] [1..474]
gi|109079101, gi... - gi|109079103|ref|XP_001095249.1| PREDICTED: ring finger protein 14 isoform 4 [Macaca mulatta], gi|10...
 6.0E-89 [1..474] [1..474]
gi|57042714, gi|... - gi|73949443|ref|XP_849246.1| PREDICTED: similar to RING finger protein 14 (Androgen receptor-associa...
 3.0E-87 [1..474] [1..474]
gi|148225442, gi... - gi|54038664|gb|AAH84251.1| LOC495084 protein [Xenopus laevis], gi|148225442|ref|NP_001088253.1| hypo...
 3.0E-84 [1..471] [1..467]
RNF14_MOUSE - E3 ubiquitin-protein ligase RNF14 OS=Mus musculus GN=Rnf14 PE=1 SV=2
 3.0E-83 [1..468] [1..469]
gi|149017388, gi... - gi|73909209|gb|AAI03649.1| Rnf14 protein [Rattus norvegicus], gi|197927419|ref|NP_001030167.1| ring ...
 9.0E-83 [1..474] [1..479]

Back

Predicted Domain #1
Region A:
Residues: [1-214] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEDREAQE DELLALASIY DGDEFRKAES VQGGETRIYL DLPQNFKIFV SGNSNECLQN  60
   61 SGFEYTICFL PPLVLNFELP PDYPSSSPPS FTLSGKWLSP TQLSALCKHL DNLWEEHRGS 120
  121 VVLFAWMQFL KEETLAYLNI VSPFELKIGS QKKVQRRTAQ ASPNTELDFG GAAGSDVDQE 180
  181 EIVDERAVQD VESLSNLIQE ILDFDQAQQI KCFN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 22.522879
Match: 2ebmA
Description: No description for 2ebmA was found.

Predicted Domain #2
Region A:
Residues: [215-303] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKLFLCSICF CEKLGSECMY FLECRHVYCK ACLKDYFEIQ IRDGQVQCLN CPEPKCPSVA  60
   61 TPGQVKELVE AELFARYDRL LLQSSLDLM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.0
Match: 1wimA
Description: Solution Structure of the RING finger Domain of the human UbcM4-interacting Protein 4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.97121728620188 bayes_pls_golite062009
small conjugating protein ligase activity 5.78935175140238 bayes_pls_golite062009
acid-amino acid ligase activity 4.75377804653841 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.72498741013971 bayes_pls_golite062009
protein binding 2.64803540957326 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.57382484274962 bayes_pls_golite062009
nucleic acid binding 2.32387297115017 bayes_pls_golite062009
DNA binding 2.00904221080834 bayes_pls_golite062009
transcription activator activity 1.45530270292081 bayes_pls_golite062009
ligase activity 1.28164271879607 bayes_pls_golite062009
transcription factor activity 1.22579085356684 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
transcription factor binding 1.11842175076436 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
sequence-specific DNA binding 0.926364718530146 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.90321253993065 bayes_pls_golite062009
hydrolase activity 0.52386813728704 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
transcription repressor activity 0.350170315296021 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.24963159801049 bayes_pls_golite062009
transcription cofactor activity 0.233838999434784 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [304-384] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADVVYCPRPC CQLPVMQEPG CTMGICSSCN FAFCTLCRLT YHGVSPCKVT AEKLMDLRNE  60
   61 YLQADEANKR LLDQRYGKRV I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.39794
Match: 2jmoA
Description: No description for 2jmoA was found.

Predicted Domain #4
Region A:
Residues: [385-474] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKALEEMESK EWLEKNSKSC PCCGTPIEKL DGCNKMTCTG CMQYFCWICM GSLSRANPYK  60
   61 HFNDPGSPCF NRLFYAVDVD DDIWEDEVED

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1wd2A
Description: Solution Structure of the C-terminal RING from a RING-IBR-RING (TRIAD) motif
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ubiquitin-protein ligase activity 5.97121728620188 bayes_pls_golite062009
small conjugating protein ligase activity 5.78935175140238 bayes_pls_golite062009
acid-amino acid ligase activity 4.75377804653841 bayes_pls_golite062009
binding 2.78710909602478 bayes_pls_golite062009
transcription regulator activity 2.72498741013971 bayes_pls_golite062009
protein binding 2.64803540957326 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 2.57382484274962 bayes_pls_golite062009
nucleic acid binding 2.32387297115017 bayes_pls_golite062009
DNA binding 2.00904221080834 bayes_pls_golite062009
transcription activator activity 1.45530270292081 bayes_pls_golite062009
ligase activity 1.28164271879607 bayes_pls_golite062009
transcription factor activity 1.22579085356684 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.2126425713931 bayes_pls_golite062009
transcription factor binding 1.11842175076436 bayes_pls_golite062009
ubiquitin-specific protease activity 1.03469202541773 bayes_pls_golite062009
sequence-specific DNA binding 0.926364718530146 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.90321253993065 bayes_pls_golite062009
hydrolase activity 0.52386813728704 bayes_pls_golite062009
cysteine-type peptidase activity 0.50197530717959 bayes_pls_golite062009
transcription repressor activity 0.350170315296021 bayes_pls_golite062009
ubiquitin thiolesterase activity 0.265769062717221 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.24963159801049 bayes_pls_golite062009
transcription cofactor activity 0.233838999434784 bayes_pls_golite062009
catalytic activity 0.14112008370434 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle