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Protein Overview: UBE2D2

General Information:
Name(s) found: UBE2D2 [HGNC (HUGO)]
Description(s) found:
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  • gi|60686986|gb|AAX35690.1| ubiquitin-conjugating enzyme E2 D2 transcript variant 1 [Homo sapiens] [NCBI NR]
  • gi|54673819|gb|AAH33349.1| Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) [Homo sapiens] [NCBI NR]
  • gi|51338685|sp|P62837.1|UB2D2_HUMAN RecName: Full=Ubiquitin-conjugating enzyme E2 D2; AltName: Full=Ubiquitin-protein ligase D2; AltName: Full=Ubiquitin carrier protein D2; AltName: Full=Ubiquitin-conjugating enzyme E2-17 kDa 2; AltName: Full=E2(17)KB 2 [NCBI NR]
  • gi|4507775|ref|NP_003330.1| ubiquitin-conjugating enzyme E2D 2 isoform 1 [Homo sapiens] [NCBI NR]
  • gi|193785545|dbj|BAG50911.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|193785525|dbj|BAG50891.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|157880610|pdb|1W4U|A Chain A, Nmr Solution Structure Of The Ubiquitin Conjugating Enzyme Ubch5b [NCBI NR]
  • gi|157880419|pdb|1UR6|A Chain A, Nmr Based Structural Model Of The Ubch5b-Cnot4 Complex [NCBI NR]
  • gi|119582500|gb|EAW62096.1| ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119582499|gb|EAW62095.1| ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|1145689|gb|AAA91460.1| UbcH5B [NCBI NR]
  • ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) [HGNC (HUGO)]
  • (P62837) Ubiquitin-conjugating enzyme E2 D2 (EC 6.3.2.19) (Ubiquitin-protein ligase D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (E2(17)KB 2) [Swiss-Prot]
  • Ubiquitin-conjugating enzyme E2 D2 OS=Homo sapiens GN=UBE2D2 PE=1 SV=1 [Swiss-Prot]
  • Ubiquitin-conjugating enzyme E2-17 kDa 2 [hmr_yeast5_DM3-1_pombe.fasta]
  • ubiquitin-conjugating enzyme E2D 2 isoform 1; ubiquitin carrier protein; ubiquitin-conjugating enzyme E2-17 kDa 2 [HMR_022704.fasta]
  • ubiquitin-conjugating enzyme E2D 2 isoform 1; ubiquitin carrier protein; ubiquitin-conjugating enzyme E2-17 kDa 2; ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5) [071204_hmrz_cont.fasta]
  • PREDICTED: similar to ubiquitin conjugating enzyme [Pan troglodytes]gi|54673819|gb|AAH33349.1| Ubiquitin-conjugating enzyme E2D 2, isoform 1 [Homo sapiens]gi|9910600|ref|NP_064296.1| ubiquitin-conjugating enzyme E2D 2 [Mus musculus]gi|4507775|ref|NP_00 [nrdb_11152004_Chlamydomonas]
  • Ubiquitin-conjugating enzyme E2 D2 (Ubiquitin-protein ligase D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (E2(17)KB 2) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Ubiquitin-conjugating enzyme E2 D2 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_003339) ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast); UbcH5B; ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5) [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • ubiquitin-conjugating enzyme E2D 2 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • ubiquitin-conjugating enzyme E2D 2 isoform 1; ubiquitin carrier protein; ubiquitin-conjugating enzyme E2-17 kDa 2; ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5) [Homo sapiens] [HumanGallus06162005.fasta]
  • ubiquitin-conjugating enzyme E2D 2 isoform 1; ubiquitin carrier protein; ubiquitin-conjugating enzyme E2-17 kDa 2 [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Chain A, Nmr Solution Structure Of The Ubiquitin Conjugating Enzyme Ubch5b [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Nmr Based Structural Model Of The Ubch5b-Cnot4 Complex [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • ubiquitin-conjugating enzyme E2 D2 transcript variant 1 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • UbcH5B [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=UBE2D2 Ubiquitin-conjugating enzyme E2 D2 [human-ipi-250309-contam.fasta]
  • IPI:IPI00332376.4|SWISS-PROT:P62837|ENSEMBL:ENSP00000381717|REFSEQ:NP_003330|H-INV:HIT000003902 Tax_Id=9606 Gene_Symbol=UBE2D2 Ubiquitin-conjugating enzyme E2 D2 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=UBE2D2 Ubiquitin-conjugating enzyme E2 D2 ENSG00000131508 IPI00332376 IPI00019932 [drosphohumanreversed.fasta]
  • P62837;P51669;Q3MN78; RecName: Full=Ubiquitin-conjugating enzyme E2 D2; AltName: Full=Ubiquitin-protein ligase D2; AltName: Full=Ubiquitin carrier protein D2; AltName: Full=Ubiquitin-conjugating enzyme E2-17 kDa 2; AltName: Full=Ubiquitin-conjugating enzyme E2(17)KB 2; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Ubiquitin-conjugating enzyme E2 D2 OS=Homo sapiens GN=UBE2D2 [011711_HMR.fasta]
  • IPI:IPI00332376.4|SWISS-PROT:P62837|TREMBL:D3DQC9|ENSEMBL:ENSP00000381717|REFSEQ:NP_003330|H-INV:HIT000003902 Tax_Id=9606 Gene_Symbol=UBE2D2 Ubiquitin-conjugating enzyme E2 D2 [ipi.HUMAN.fasta.20100406]
  • GeneSymbol=UBE2D2 Synonyms=E2(17)KB2|PUBC1|UBC4|UBC4/5|UBCH5B ubiquitin-conjugating enzyme E2 D2 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00332376.4|SWISS-PROT:P62837|ENSEMBL:ENSP00000381717;ENSP00000381718|REFSEQ:NP_003330|H-INV:HIT000003902|VEGA:OTTHUMP00000223475;OTTHUMP00000223478 Tax_Id=9606 Gene_Symbol=UBE2D2 Ubiquitin-conjugating enzyme E2 D2 [ipi.HUMAN.20110912.fasta]
  • Ubiquitin-conjugating enzyme E2 D2 GN=UBE2D2 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 147 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY  60
   61 PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV 120
  121 PEIARIYKTD REKYNRIARE WTQKYAM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] PSI-BLAST 57.522879 The 1.1A crystallographic structure of ubiquitin-conjugating enzyme (ubc-2) from Caenorhabditis elegans: functional and evolutionary significance

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  11.3486134076304 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  11.2964721480824 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  10.2401422444624 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  8.93602533934698 bayes_pls_golite062009
  • HLH domain binding
    		•  8.10904818707269 bayes_pls_golite062009
  • ligase activity
    		•  5.17219147802758 bayes_pls_golite062009
  • SUMO ligase activity
    		•  3.88357560284404 bayes_pls_golite062009
  • ISG15 ligase activity
    		•  3.37361650623694 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21355731489173 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13970605403492 bayes_pls_golite062009
  • DNA binding
    		•  1.95596447916631 bayes_pls_golite062009
  • protein binding
    		•  1.77678273247394 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.5236035191291 bayes_pls_golite062009
  • transcription activator activity
    		•  1.19240180311941 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  0.715654744941217 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58835335751383 bayes_pls_golite062009
  • kinase activity
    		•  0.519703305315987 bayes_pls_golite062009
  • protein kinase activity
    		•  0.443948654247666 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.373779304908933 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.182854082413338 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.122859425935324 bayes_pls_golite062009
  • transferase activity
    		•  0.0984525836903841 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0104967529560147 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle