YRC Public Data Repository - Protein Structure Prediction

Protein:	UBE2D2
Organism:	Homo sapiens
Length:	147 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for UBE2D2.

Description	E-value	Query Range	Subject Range
gi\|116487484, gi... - gi\|118404876\|ref\|NP_001072891.1\| ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog) [Xenopus (Silur... gi\|54311502, gi\|... - gi\|54311502\|gb\|AAH84849.1\| LOC495381 protein [Xenopus laevis], gi\|49899030\|gb\|AAH76728.1\| Ube2d2-pro...	220.0	[0..1]	[147..1]
gi\|37590333, gi\|... - gi\|41152425\|ref\|NP_955958.1\| ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) [Danio rerio...	220.0	[0..1]	[147..1]
gi\|109066782 - gi\|109066782\|ref\|XP_001096263.1\| PREDICTED: similar to ubiquitin-conjugating enzyme E2D 4 (putative)... gi\|114613001, gi... - gi\|114613001\|ref\|XP_519070.2\| PREDICTED: ubiquitin-conjugating enzyme E2D 4 (putative) isoform 4 [Pa... UBE2D4 - ubiquitin-conjugating enzyme E2D 4 (putative)	219.0	[0..1]	[147..1]
gi\|62738886 - gi\|62738886\|pdb\|1Z2U\|A Chain A, The 1.1a Crystallographic Structure Of Ubiquitin- Conjugating Enzyme...	219.0	[0..1]	[147..4]
gi\|125550147, gi... - gi\|90399233\|emb\|CAH68307.1\| B0811B10.8 [Oryza sativa (indica cultivar-group)], gi\|125550147\|gb\|EAY95... gi\|195617724, gi... - gi\|238012450\|gb\|ACR37260.1\| unknown [Zea mays], gi\|226492411\|ref\|NP_001148222.1\| ubiquitin-conjugati... gi\|241939908, gi... - gi\|242077578\|ref\|XP_002448725.1\| hypothetical protein SORBIDRAFT_06g032120 [Sorghum bicolor], gi\|241... gi\|32488376, gi\|... - gi\|50929483\|ref\|XP_474269.1\| OSJNBa0043A12.6 [Oryza sativa (japonica cultivar-group)], gi\|32488376\|e...	218.0	[0..1]	[147..1]
gi\|87239726 - gi\|87239726\|emb\|CAJ57642.1\| putative ubiquitin conjugating enzyme 2 [Oesophagostomum dentatum]	218.0	[0..1]	[147..1]
gi\|48095652, gi\|... - ref\|XP_392337.1\| similar to Ubiquitin-conjugating enzyme E2-17 kDa (Ubiquitin-protein ligase) (Ubiqu...	217.0	[0..1]	[147..1]

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Predicted Domain #1

Region A:
Residues: [1-147]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALKRIHKEL NDLARDPPAQ CSAGPVGDDM FHWQATIMGP NDSPYQGGVF FLTIHFPTDY  60
   61 PFKPPKVAFT TRIYHPNINS NGSICLDILR SQWSPALTIS KVLLSICSLL CDPNPDDPLV 120
  121 PEIARIYKTD REKYNRIARE WTQKYAM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	57.522879
Match:	1z2uA
Description:	The 1.1A crystallographic structure of ubiquitin-conjugating enzyme (ubc-2) from Caenorhabditis elegans: functional and evolutionary significance
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ubiquitin-protein ligase activity	11.3486134076304	bayes_pls_golite062009
small conjugating protein ligase activity	11.2964721480824	bayes_pls_golite062009
acid-amino acid ligase activity	10.2401422444624	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	8.93602533934698	bayes_pls_golite062009
HLH domain binding	8.10904818707269	bayes_pls_golite062009
ligase activity	5.17219147802758	bayes_pls_golite062009
SUMO ligase activity	3.88357560284404	bayes_pls_golite062009
ISG15 ligase activity	3.37361650623694	bayes_pls_golite062009
transcription regulator activity	2.21355731489173	bayes_pls_golite062009
nucleic acid binding	2.13970605403492	bayes_pls_golite062009
DNA binding	1.95596447916631	bayes_pls_golite062009
protein binding	1.77678273247394	bayes_pls_golite062009
binding	1.75350658654805	bayes_pls_golite062009
transcription repressor activity	1.5236035191291	bayes_pls_golite062009
transcription activator activity	1.19240180311941	bayes_pls_golite062009
catalytic activity	0.891402822028799	bayes_pls_golite062009
NEDD8 ligase activity	0.715654744941217	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.58835335751383	bayes_pls_golite062009
kinase activity	0.519703305315987	bayes_pls_golite062009
protein kinase activity	0.443948654247666	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.373779304908933	bayes_pls_golite062009
protein serine/threonine kinase activity	0.182854082413338	bayes_pls_golite062009
transcription corepressor activity	0.122859425935324	bayes_pls_golite062009
transferase activity	0.0984525836903841	bayes_pls_golite062009
transcription factor binding	0.0104967529560147	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: