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Protein Overview: LDHA

General Information:
Name(s) found: LDHA [HGNC (HUGO)]
Description(s) found:
Found 44 descriptions.
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  • lactate dehydrogenase A [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 332 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG  60
   61 EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI 120
  121 IPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV 180
  181 HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE 240
  241 VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI 300
  301 SDLVKVTLTS EEEARLKKSA DTLWGIQKEL QF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..332] PSI-BLAST 111.0 Lactate dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • malate dehydrogenase activity
    		•  7.69241456337154 bayes_pls_golite062009
  • L-malate dehydrogenase activity
    		•  5.35837481826138 bayes_pls_golite062009
  • lactate dehydrogenase activity
    		•  4.66418715735914 bayes_pls_golite062009
  • malic enzyme activity
    		•  2.98382582538724 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  2.94416173750168 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.75947908917144 bayes_pls_golite062009
  • L-lactate dehydrogenase activity
    		•  2.59062377380589 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.58076782195922 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  2.26153457113968 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.88605255677599 bayes_pls_golite062009
  • binding
    		•  1.76718756313666 bayes_pls_golite062009
  • catalytic activity
    		•  1.67029398049886 bayes_pls_golite062009
  • protein binding
    		•  1.47646217957458 bayes_pls_golite062009
  • NAD or NADH binding
    		•  1.32276254629683 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.22444609393125 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  1.16811519855038 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  0.91702493082811 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.788034697021177 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  0.714637370305282 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.621273823467575 bayes_pls_golite062009
  • coenzyme binding
    		•  0.59785037604907 bayes_pls_golite062009
  • DNA binding
    		•  0.525227236870065 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.523513694229008 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.459537641913493 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  0.216422278300306 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.19685680097448 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.192594057004213 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.177044638410302 bayes_pls_golite062009
  • malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
    		•  0.120195861875768 bayes_pls_golite062009
  • signal transducer activity
    		•  0.0433763403499039 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.0433763403499039 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  4.92199819939532E-4 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.73

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle