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Protein Overview: SLC6A13

General Information:
Name(s) found: SLC6A13 [HGNC (HUGO)]
Description(s) found:
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  • gi|21361581|ref|NP_057699.2| solute carrier family 6 (neurotransmitter transporter, GABA), member 13 [Homo sapiens] [NCBI NR]
  • gi|209572724|sp|Q9NSD5.3|S6A13_HUMAN RecName: Full=Sodium- and chloride-dependent GABA transporter 2; Short=GAT-2; AltName: Full=Solute carrier family 6 member 13 [NCBI NR]
  • gi|189069259|dbj|BAG36291.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|18490233|gb|AAH22392.1| Solute carrier family 6 (neurotransmitter transporter, GABA), member 13 [Homo sapiens] [NCBI NR]
  • gi|119609380|gb|EAW88974.1| solute carrier family 6 (neurotransmitter transporter, GABA), member 13, isoform CRA_c [Homo sapiens] [NCBI NR]
  • solute carrier family 6 (neurotransmitter transporter, GABA), member 13 [HGNC (HUGO)]
  • Sodium- and chloride-dependent GABA transporter 2 OS=Homo sapiens GN=SLC6A13 PE=1 SV=3 [Swiss-Prot]
  • Hypothetical protein [hmr_yeast5_DM3-1_pombe.fasta]
  • solute carrier family 6 (neurotransmitter transporter, GABA), member 13; GABA transport protein [HMR_022704.fasta]
  • solute carrier family 6 (neurotransmitter transporter, GABA), member 13 [Homo sapiens]gi|18490233|gb|AAH22392.1| Solute carrier family 6 (neurotransmitter transporter, GABA), member 13 [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Solute carrier family 6 (Neurotransmitter transporter, GABA), member 13 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_016615) solute carrier family 6 (neurotransmitter transporter, GABA), member 13; GABA transport protein [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • solute carrier family 6 (neurotransmitter transporter, GABA), member 13 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • solute carrier family 6 (neurotransmitter transporter, GABA), member 13; GABA transport protein [Homo sapiens] [HumanGallus06162005.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • solute carrier family 6 (neurotransmitter transporter, GABA), member 13, isoform CRA_c [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Solute carrier family 6 (neurotransmitter transporter, GABA), member 13 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER, GABA), MEMBER 13 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SLC6A13 Sodium- and chloride-dependent GABA transporter 2 [human-ipi-250309-contam.fasta]
  • IPI:IPI00009914.3|SWISS-PROT:Q9NSD5|TREMBL:B4DJS3|ENSEMBL:ENSP00000339260|REFSEQ:NP_057699|H-INV:HIT000039517|VEGA:OTTHUMP00000159505;OTTHUMP00000166145 Tax_Id=9606 Gene_Symbol=SLC6A13 Sodium- and chloride-dependent GABA transporter 2 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=SLC6A13 Solute carrier family 6 (Neurotransmitter transporter, GABA), member 13 ENSG00000010379 IPI00009914 IPI00152335 IPI00797110 IPI00383031 IPI00796525 IPI00797000 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SLC6A13 Solute carrier family 6 (Neurotransmitter transporter, GABA), member 13 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • sodium- and chloride-dependent GABA transporter 2 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q9NSD5;Q8TCC2; RecName: Full=Sodium- and chloride-dependent GABA transporter 2; AltName: Full=Solute carrier family 6 member 13; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Sodium- and chloride-dependent GABA transporter 2 OS=Homo sapiens GN=SLC6A13 [011711_HMR.fasta]
  • GeneSymbol=SLC6A13 Synonyms=GAT-2|GAT2 sodium- and chloride-dependent GABA transporter 2 isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00009914.3|SWISS-PROT:Q9NSD5|ENSEMBL:ENSP00000339260|REFSEQ:NP_057699|H-INV:HIT000039517|VEGA:OTTHUMP00000237738 Tax_Id=9606 Gene_Symbol=SLC6A13 Sodium- and chloride-dependent GABA transporter 2 [ipi.HUMAN.20110912.fasta]
  • Sodium- and chloride-dependent GABA transporter 2 GN=SLC6A13 [Doctor+uniprot-HUMAN-120911.fasta]
  • IPI:IPI00009914.3|SWISS-PROT:Q9NSD5|TREMBL:B4DJS3|ENSEMBL:ENSP00000339260|REFSEQ:NP_057699|H-INV:HIT000039517|VEGA:OTTHUMP00000237738 Tax_Id=9606 Gene_Symbol=SLC6A13 Sodium- and chloride-dependent GABA transporter 2 [ipi.HUMAN.fasta.20110927]
    • Organism: Homo sapiens
    Length: 602 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSRVSGTTS NGETKPVYPV MEKKEEDGTL ERGHWNNKME FVLSVAGEII GLGNVWRFPY  60
   61 LCYKNGGGAF FIPYLVFLFT CGIPVFLLET ALGQYTSQGG VTAWRKICPI FEGIGYASQM 120
  121 IVILLNVYYI IVLAWALFYL FSSFTIDLPW GGCYHEWNTE HCMEFQKTNG SLNGTSENAT 180
  181 SPVIEFWERR VLKISDGIQH LGALRWELAL CLLLAWVICY FCIWKGVKST GKVVYFTATF 240
  241 PYLMLVVLLI RGVTLPGAAQ GIQFYLYPNL TRLWDPQVWM DAGTQIFFSF AICLGCLTAL 300
  301 GSYNKYHNNC YRDCIALCFL NSGTSFVAGF AIFSILGFMS QEQGVPISEV AESGPGLAFI 360
  361 AYPRAVVMLP FSPLWACCFF FMVVLLGLDS QFVCVESLVT ALVDMYPHVF RKKNRREVLI 420
  421 LGVSVVSFLV GLIMLTEGGM YVFQLFDYYA ASGMCLLFVA IFESLCVAWV YGAKRFYDNI 480
  481 EDMIGYRPWP LIKYCWLFLT PAVCTATFLF SLIKYTPLTY NKKYTYPWWG DALGWLLALS 540
  541 SMVCIPAWSL YRLGTLKGPF RERIRQLMCP AEDLPQRNPA GPSAPATPRT SLLRLTELES 600
  601 HC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..602] PSI-BLAST 75.221849 Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glycine transmembrane transporter activity
    		•  11.3462233177624 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  7.22946100807286 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  6.81299720354921 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  6.70367174546308 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  6.56670564439223 bayes_pls_golite062009
  • neutral amino acid transmembrane transporter activity
    		•  6.33167860290665 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  5.71289406236765 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  5.69783123069145 bayes_pls_golite062009
  • transporter activity
    		•  5.41729552690402 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  5.3581057816165 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  5.33581060534257 bayes_pls_golite062009
  • monoamine transmembrane transporter activity
    		•  5.31806171557443 bayes_pls_golite062009
  • serotonin transmembrane transporter activity
    		•  5.22437090102976 bayes_pls_golite062009
  • norepinephrine transmembrane transporter activity
    		•  5.09475702546654 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  4.68541050294042 bayes_pls_golite062009
  • taurine transmembrane transporter activity
    		•  4.61676680068455 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  4.6018168706595 bayes_pls_golite062009
  • taurine:sodium symporter activity
    		•  4.44443197285659 bayes_pls_golite062009
  • neurotransmitter transporter activity
    		•  4.39219594760011 bayes_pls_golite062009
  • taurine binding
    		•  4.32148954519383 bayes_pls_golite062009
  • beta-alanine transmembrane transporter activity
    		•  4.32148954519383 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  3.87108500507564 bayes_pls_golite062009
  • monocarboxylic acid transmembrane transporter activity
    		•  3.84070781430742 bayes_pls_golite062009
  • cation:amino acid symporter activity
    		•  3.743834410703 bayes_pls_golite062009
  • L-amino acid transmembrane transporter activity
    		•  3.59581534621744 bayes_pls_golite062009
  • gamma-aminobutyric acid:sodium symporter activity
    		•  3.54502199515084 bayes_pls_golite062009
  • L-gamma-aminobutyric acid transmembrane transporter activity
    		•  3.54502199515084 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  3.52796002058936 bayes_pls_golite062009
  • organic acid:sodium symporter activity
    		•  3.13700347625317 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  3.06163068745863 bayes_pls_golite062009
  • symporter activity
    		•  3.06163068745863 bayes_pls_golite062009
  • D-amino acid transmembrane transporter activity
    		•  3.05547330089228 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.96397568544208 bayes_pls_golite062009
  • sodium ion transmembrane transporter activity
    		•  2.96263002501356 bayes_pls_golite062009
  • neurotransmitter:sodium symporter activity
    		•  2.85886896504752 bayes_pls_golite062009
  • solute:sodium symporter activity
    		•  2.69043348576901 bayes_pls_golite062009
  • dopamine transmembrane transporter activity
    		•  2.58457054403528 bayes_pls_golite062009
  • dopamine:sodium symporter activity
    		•  2.58457054403528 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.25031429733377 bayes_pls_golite062009
  • sodium:amino acid symporter activity
    		•  2.11262345327121 bayes_pls_golite062009
  • binding
    		•  2.09841803960057 bayes_pls_golite062009
  • cation channel activity
    		•  1.98082939418842 bayes_pls_golite062009
  • amine binding
    		•  1.94062923967142 bayes_pls_golite062009
  • ion channel activity
    		•  1.46844692044197 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.43924755059525 bayes_pls_golite062009
  • signal transducer activity
    		•  1.43924755059525 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.43469451491638 bayes_pls_golite062009
  • channel activity
    		•  1.43469451491638 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.42613760305472 bayes_pls_golite062009
  • cocaine binding
    		•  1.19517364220938 bayes_pls_golite062009
  • receptor activity
    		•  0.933085226787869 bayes_pls_golite062009
  • potassium:amino acid symporter activity
    		•  0.9050760910728 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.849801862133405 bayes_pls_golite062009
  • protein binding
    		•  0.541360409289497 bayes_pls_golite062009
  • norephinephrine:sodium symporter activity
    		•  0.331385084269681 bayes_pls_golite062009
  • neurotransmitter binding
    		•  0.276720775023801 bayes_pls_golite062009
  • protein complex binding
    		•  0.131316764331102 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle