Protein Overview: SRP72

General Information:
Name(s) found:	SRP72 / YPL210C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|81175196\|sp\|P38688.2\|SRP72_YEAST RecName: Full=Signal recognition particle subunit SRP72; AltName: Full=Signal recognition particle 72 kDa protein homolog [NCBI NR] gi\|37362700\|ref\|NP_015114.2\| Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; Srp72p [Saccharomyces cerevisiae] [NCBI NR] Signal recognition particle subunit SRP72 OS=Saccharomyces cerevisiae GN=SRP72 PE=1 SV=2 [Swiss-Prot] SRP72 Signal recognition particle protein [mips] Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane [SGD] Chr XVI from 156211-154289, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] SRP72 SGDID:S0006131, Chr XVI from 156211-154289, reverse complement, Verified ORF [yeastflysequest.fasta] Component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] SRP72 SGDID:S000006131, Chr XVI from 156211-154289, reverse complement, Verified ORF, "Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticu [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Signal recognition particle subunit SRP72 (Signal recognition particle 72 kDa protein homolog) [nr-271106-contam.fasta] Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; Srp72p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SRP72 SGDID:S000006131, Chr XVI from 156211-154289, reverse complement, Verified ORF, "Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Signal recognition particle subunit SRP72 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRP72 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SRP72 SGDID:S000006131, Chr XVI from 156212-154290, Genome Release 64-1-1, reverse complement, Verified ORF, "Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane" [yeast-030211-contam.fasta] SRP72 SGDID:S000006131, Chr XVI from 156212-154290, Genome Release 64-2-1, reverse complement, Verified ORF, "Core component of the signal recognition particle (SRP); the SRP is a ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane" [20141208_orf_trans.fasta] YPL210C SGDID:S000006131, Chr XVI from 156212-154290, Genome Release 64-1-1, reverse complement, Verified ORF, "Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	640 amino acids
Gene Ontology:
Cellular Component:	signal recognition particle, endoplasmic reticulum targeting [IDA]
Biological Process:	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [IC] protein targeting to ER [IPI]
Molecular Function:	signal sequence binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAKDNLTNLL SQLNIQLSQD EHSQVEQTCV KLLDSGCENP ADVFRRCLVA VIQQDKYQKA  60
   61 LHYLKKFKHI DDKYGRKFAL EKLYIFYKLN MPDEFNTLYT AIITDDLDTV LKKDIESLRG 120
  121 ILHVRAQYCY KNGLYQEAFK IYQHLASHNE KDQDSQIELS CNERVPLSVA TELMNRSPLV 180
  181 TPMDESSYDL LFNESFIMAS VGKYDKAIEL LEKALQGATN EGYQNDINTI KLQLSFVLQM 240
  241 VGKTAQSKEI LKGLLQELKA DSPFSLICQN NLNAFVDFSK YNTNFNLLLR ELNVEKLNTF 300
  301 NLQTFTHEQW SNIQRNVLFL RLFNNVKIHS QESLLSRTFD KYSKLVDNVT LESYKTQAKK 360
  361 LYHHTTKTIL SGTDGSTIGI LLLTIQLLII EKEWENAIRI GELFLNESWK SSFEKFNDSQ 420
  421 AIVCYILFEL YKIKGRNNSK SVLLKKLGSV RVQLSGKIQE NIPFWKHVGF ELLSMGNAKE 480
  481 SKALLREISN FSKGDADVLV DRVVSSDSLD IAQGIDLVRD IDIDKLIQLG VKPLESSAKR 540
  541 SKNTAVSKVQ KRKVLELKKK RKIKRLEKFL QGRDTSKLPD PERWLPLRDR STYRPKKKQQ 600
  601 GAKQTQGGAM NKKSEQALDI SKKGKPTVNK KPKNKKKGRK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		LHP1 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72
View Details	(MIPS) Mewes HW, et al. (2004)		SEC65 SRP14 SRP21 SRP54 SRP68 SRP72
View Details	Krogan NJ, et al. (2006)		LHP1 SEC65 SRP14 SRP21 SRP54 SRP68 SRP72 YCR090C
View Details	Gavin AC, et al. (2006)		SEC65 SRP14 SRP54 SRP68 SRP72
View Details	Gavin AC, et al. (2002)		BEM2 LHP1 SEC65 SRO9 SRP14 SRP21 SRP54 SRP68 SRP72
View Details	Qiu et al. (2008)		SEC65 SRP14 SRP21 SRP54 SRP68 SRP72

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	HMT1	SRP72	1	Unpublished Fields Lab Data
View Screen	CDC48	SRP72	1	Unpublished Fields Lab Data
View Screen	CDC53	SRP72	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	SRP72	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..305]	PSI-BLAST	11.0	Peroxin pex5 (peroxisomal targeting signal 1 (PTS1) receptor)
2	View Details	[306..491]	MSA	2.962996	View MSA. No confident structure predictions are available.
3	View Details	[492..640]	MSA	2.563981	View MSA. No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2