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Protein Overview: TRE1

General Information:
Name(s) found: TRE1 / YPL176C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 783 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process [IGILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVNTRGYTTL PNVEEPANNS QDELNSQDFE QAIGMPSEPP VYVEEMGMEE PQAPEAFSEK  60
   61 VQRFRMCFEN NVVIPVKKNV VDPLAQMISL ASEKFDLFLS KIGNVMVMRR IFYIMMMSII 120
  121 AALIIASDRL PNGKARGSNG SFSDHDLLLQ YARKSIDLSK IERDLEYISS MPHMSGTSGD 180
  181 AAIRHYIKES FDKNGIRLAG EEEFMAYSNY PGNVSLRVYS KDDTEGFDIP LNEENFNPMS 240
  241 HNGQLNNIPV IYANKASLDD MASMQDQGLL NGDFILLVHY GDYVFQQMLT AQEYGAKAII 300
  301 FISEPYQDNK DVIQMKSVAL PQYGTGDALT PEWEGSIRDP IDATEAKCLP KIPSIPISAN 360
  361 QGDKILAILS DTGVKFSNNL FSGSLNDCRL DLLVQTAIRE RHPVHDIVGK IEGSEQAGRA 420
  421 IVIAAPRNSA SYGTMYPSFG TVVLLSLIQL YQEMVYKFDW KPLRNIYFIS FGGSEFNEAG 480
  481 ATELMEKRTE ALKSEIYTII DVGQIGIWDD SNNLEIQCHP LLVDLFQKNM TSRKFNVKVD 540
  541 NVHQFGDWTP YLAQGIPVAI ISSPGVMNRE HPIYTVEDKF DFIKDKLRDK KKGEVLSEIM 600
  601 LYLVEKSLEL IDDPFIPFSI SNYVDFLSTT LKDLQKECPD TVNFDEVFLG TTLWENTKLQ 660
  661 FEKWKSEWTE LMYGAGTYIE PTIIAINRWS WNYLLSLIGV TQCLEEGLMD RTFYKNVIFG 720
  721 PKLWVDKGDP LRSWTFPEIR DTIAIKDWSS VQVQANTLGT ILQNTARYFL ENKNLHGINT 780
  781 NEF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..136] deduced N/A No confident structure predictions are available.
    2 View Details [137..209]
    [322..348]
    [398..619]    		 PSI-BLAST 277.54902 Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain
    3 View Details [210..321]
    [349..397]
    [620..783]    		 PSI-BLAST 277.54902 Transferrin receptor ectodomain, C-terminal domain; Transferrin receptor ectodomain, apical domain; Transferrin receptor ectodomain, protease-like domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.26568153906254 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.98334117181651 bayes_pls_golite062009
  • hydrolase activity
    		•  2.9250662598192 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.06300314555202 bayes_pls_golite062009
  • signal transducer activity
    		•  1.98411113807388 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.98411113807388 bayes_pls_golite062009
  • receptor activity
    		•  1.93707013781136 bayes_pls_golite062009
  • metallopeptidase activity
    		•  1.75261723003176 bayes_pls_golite062009
  • exopeptidase activity
    		•  1.5759162922092 bayes_pls_golite062009
  • catalytic activity
    		•  1.3989281287879 bayes_pls_golite062009
  • transferrin receptor activity
    		•  1.08060244646522 bayes_pls_golite062009
  • carboxypeptidase activity
    		•  0.891655769761122 bayes_pls_golite062009
  • binding
    		•  0.700980045216992 bayes_pls_golite062009
  • metalloexopeptidase activity
    		•  0.472688733072762 bayes_pls_golite062009
  • metallocarboxypeptidase activity
    		•  0.180859448845431 bayes_pls_golite062009
  • aminopeptidase activity
    		•  0.0966237570696103 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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