Protein Overview: MRPL40

General Information:
Name(s) found:	MRPL40 / YPL173W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6325084\|ref\|NP_015152.1\| Mitochondrial ribosomal protein of the large subunit; Mrpl40p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S65185 ribosomal protein YmL40, mitochondrial - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1710604\|sp\|P36534.2\|RM40_YEAST RecName: Full=54S ribosomal protein L40, mitochondrial; AltName: Full=YmL40 [NCBI NR] gi\|1370365\|emb\|CAA97880.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] 54S ribosomal protein L40, mitochondrial OS=Saccharomyces cerevisiae GN=MRPL40 PE=1 SV=2 [Swiss-Prot] MRPL40 Mitochondrial ribosomal protein, large subunit [mips] Mitochondrial ribosomal protein of the large subunit [SGD] (P36534) Mitochondrial 60S ribosomal protein L40 (YmL40) [4932.FASTACCERV.txt] Chr XVI from 223142-224035 [hmr_yeast5_DM3-1_pombe.fasta] MRPL40, Chr XVI from 223142-224035 [yeast_orfs2] MRPL40 SGDID:S0006094, Chr XVI from 223142-224035, Verified ORF [yeastflysequest.fasta] Mitochondrial ribosomal protein of the large subunit [Saccharomyces cerevisiae]gi\|1370365\|emb\|CAA97880.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|2133103\|pir\|\|S65185 ribosomal protein YmL40, mitochondrial - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] (P36534) 60S ribosomal protein L40, mitochondrial precursor (YmL40) [cerv4932.FASTAC] MRPL40 SGDID:S000006094, Chr XVI from 223142-224035, Verified ORF, "Mitochondrial ribosomal protein of the large subunit" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] 60S ribosomal protein L40, mitochondrial precursor (YmL40) [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Mitochondrial ribosomal protein of the large subunit; Mrpl40p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] 54S ribosomal protein L40, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MRPL40 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MRPL40 SGDID:S000006094, Chr XVI from 223143-224036, Genome Release 64-1-1, Verified ORF, "Mitochondrial ribosomal protein of the large subunit" [yeast-030211-contam.fasta] MRPL40 SGDID:S000006094, Chr XVI from 223143-224036, Genome Release 64-2-1, Verified ORF, "Mitochondrial ribosomal protein of the large subunit" [20141208_orf_trans.fasta] TR7425\|c0_g1_i1\|g.5186 ORF TR7425\|c0_g1_i1\|g.5186 TR7425\|c0_g1_i1\|m.5186 type:complete len:298 (+) TR7425\|c0_g1_i1:70-963(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR8445\|c0_g1_i1\|g.6029 ORF TR8445\|c0_g1_i1\|g.6029 TR8445\|c0_g1_i1\|m.6029 type:complete len:298 (+) TR8445\|c0_g1_i1:68-961(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YPL173W SGDID:S000006094, Chr XVI from 223143-224036, Genome Release 64-1-1, Verified ORF, "Mitochondrial ribosomal protein of the large subunit" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_3468\|g.2624 ORF asmbl_3468\|g.2624 asmbl_3468\|m.2624 type:complete len:298 (+) asmbl_3468:67-960(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_3348\|g.2281 ORF asmbl_3348\|g.2281 asmbl_3348\|m.2281 type:complete len:298 (+) asmbl_3348:67-960(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_3070\|g.1963 ORF ID=asmbl_3070\|g.1963 ID=asmbl_3070\|m.1963 type:complete len:298 (+) ID=asmbl_3070:67-960(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_3351\|g.2197 ORF ID=asmbl_3351\|g.2197 ID=asmbl_3351\|m.2197 type:complete len:298 (+) ID=asmbl_3351:67-960(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	297 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial large ribosomal subunit [IDA][IPI]
Biological Process:	translation [IDA]
Molecular Function:	structural constituent of ribosome [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGSYQHLSN VGSRVMKRLG NRPKNFLPHS EKFIKKSTPE FMKSDLKEVD EKTSFKSEKE  60
   61 WKFIPGDRVV VMSGASKGNI AVIKSFDKRT NSFILDENGP TKTVPVPKQF WLEGQTSHMI 120
  121 TIPVSILGKD LRLVADIDDE KTPGKTRTVA VRDVSFNGSY YDADYKKVMP YRCVKGQPDL 180
  181 IIPWPKPDPI DVQTNLATDP VIAREQTFWV DSVVRNPIPK KAIPSIRNPH SKYKRGTLTA 240
  241 KDIAKLVAPE MPLTEVRKSH LAEKKELAER EVPKLTEEDM EAIGARVFEF LEKQKRE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		MRPL10 MRPL25 MRPL40 YML6
View Details	(MIPS) Mewes HW, et al. (2004)		IMG1 IMG2 MNP1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL31 MRPL32 MRPL33 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL44 MRPL49 MRPL50 MRPL51 MRPL6 MRPL7 MRPL8 MRPL9 RML2 RTC6 YDR115W YML6
View Details	Krogan NJ, et al. (2006)		IMG2 MRP20 MRPL1 MRPL10 MRPL15 MRPL25 MRPL3 MRPL4 MRPL40 MRPL9
View Details	Qiu et al. (2008)		IMG1 IMG2 MHR1 MNP1 MRP1 MRP10 MRP17 MRP20 MRP21 MRP4 MRP49 MRP51 MRP7 MRPL1 MRPL10 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL31 MRPL32 MRPL33 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL44 MRPL49 MRPL50 MRPL51 MRPL6 MRPL7 MRPL8 MRPL9 MRPS12 MRPS16 MRPS18 MRPS8 MRPS9 PET123 RML2 RSM19 RSM26 RSM27 RSM7 RTC6 SWS2 VAR1 YDR115W YML6

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	FMP48	MRPL40	1	Unpublished Fields Lab Data
View Screen	PFK1	MRPL40	1	Unpublished Fields Lab Data
View Screen	FAR10	MRPL40	1	Unpublished Fields Lab Data
View Screen	MDM30	MRPL40	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..142]	Pfam	5.60206	KOW motif No confident structure predictions are available.
2	View Details	[143..297]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2