Protein Overview: COX11

General Information:
Name(s) found:	COX11 / YPL132W [SGD]
Description(s) found: Found 29 descriptions. SHOW ALL	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	300 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial ribosome [IDA] mitochondrial envelope [IDA] mitochondrial inner membrane [IDA ]
Biological Process:	protein complex assembly [IMP] aerobic respiration [IMP]
Molecular Function:	copper ion binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIRICPIVRS KVPLLGTFLR SDSWLAPHAL ALRRAICKNV ALRSYSVNSE QPKHTFDISK  60
   61 LTRNEIQQLR ELKRARERKF KDRTVAFYFS SVAVLFLGLA YAAVPLYRAI CARTGFGGIP 120
  121 ITDRRKFTDD KLIPVDTEKR IRISFTSEVS QILPWKFVPQ QREVYVLPGE TALAFYKAKN 180
  181 YSDKDIIGMA TYSIAPGEAA QYFNKIQCFC FEEQKLAAGE EIDMPVFFFI DPDFASDPAM 240
  241 RNIDDIILHY TFFRAHYGDG TAVSDSKKEP EMNADEKAAS LANAAILSPE VIDTRKDNSN 300
  301

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		COB COX1 COX11 COX2 COX3 MRPS17 SCO1 VAR1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC48	COX11	1	Unpublished Fields Lab Data
View Screen	RCY1	COX11	1	Unpublished Fields Lab Data
View Screen	NAF1	COX11	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..300]	MSA	35.054957	View MSA. No confident structure predictions are available.
2	View Details	[83..300]	PSI-BLAST	63.30103	Solution Structure of apoCox11, 30 structures

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
structural molecule activity	4.47117060684776	bayes_pls_golite062009
cytochrome-c oxidase activity	1.63692440621606	bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors	1.63692440621606	bayes_pls_golite062009
oxidoreductase activity, acting on heme group of donors, oxygen as acceptor	1.63692440621606	bayes_pls_golite062009
heme-copper terminal oxidase activity	1.45348828463274	bayes_pls_golite062009
binding	1.26238051646126	bayes_pls_golite062009
oxidoreductase activity	1.03472539732492	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	0.401392171756694	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.312235007946628	bayes_pls_golite062009
copper ion binding	0.19463795974816	bayes_pls_golite062009
catalytic activity	0.176396048613815	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.0231690475060109	bayes_pls_golite062009
cation transmembrane transporter activity	0.0170756391184381	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2