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Protein Overview: MIP1

General Information:
Name(s) found: MIP1 / YOR330C [SGD]
Description(s) found:
Found 11 descriptions.
SHOW ALL
  • Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; related to human POLG, which has been associated with mitochondrial diseases [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1280 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: DNA-dependent DNA replication [IDALink to PubMed article][IMPLink to PubMed article]
    mitochondrial DNA replication [IDALink to PubMed article]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYERTVLKK RSRWGLYVVV EQRGTSMTKL MVRSECMLRM VRRRPLRVQF CARWFSTKKN  60
   61 TAEAPRINPV GIQYLGESLQ RQVFGSCGGK DEVEQSDKLM ELSKKSLKDH GLWGKKTLIT 120
  121 DPISFPLPPL QGRSLDEHFQ KIGRFNSEPY KSFCEDKFTE MVARPAEWLR KPGWVKYVPG 180
  181 MAPVEVAYPD EELVVFDVET LYNVSDYPTL ATALSSTAWY LWCSPFICGG DDPAALIPLN 240
  241 TLNKEQVIIG HNVAYDRARV LEEYNFRDSK AFFLDTQSLH IASFGLCSRQ RPMFMKNNKK 300
  301 KEAEVESEVH PEISIEDYDD PWLNVSALNS LKDVAKFHCK IDLDKTDRDF FASTDKSTII 360
  361 ENFQKLVNYC ATDVTATSQV FDEIFPVFLK KCPHPVSFAG LKSLSKCILP TKLNDWNDYL 420
  421 NSSESLYQQS KVQIESKIVQ IIKDIVLLKD KPDFYLKDPW LSQLDWTTKP LRLTKKGVPA 480
  481 KCQKLPGFPE WYRQLFPSKD TVEPKITIKS RIIPILFKLS WENSPVIWSK ESGWCFNVPH 540
  541 EQVETYKAKN YVLADSVSQE EEEIRTHNLG LQCTGVLFKV PHPNGPTFNC TNLLTKSYNH 600
  601 FFEKGVLKSE SELAHQALQI NSSGSYWMSA RERIQSQFVV PSCKFPNEFQ SLSAKSSLNN 660
  661 EKTNDLAIII PKIVPMGTIT RRAVENAWLT ASNAKANRIG SELKTQVKAP PGYCFVGADV 720
  721 DSEELWIASL VGDSIFNVHG GTAIGWMCLE GTKNEGTDLH TKTAQILGCS RNEAKIFNYG 780
  781 RIYGAGAKFA SQLLKRFNPS LTDEETKKIA NKLYENTKGK TKRSKLFKKF WYGGSESILF 840
  841 NKLESIAEQE TPKTPVLGCG ITYSLMKKNL RANSFLPSRI NWAIQSSGVD YLHLLCCSME 900
  901 YIIKKYNLEA RLCISIHDEI RFLVSEKDKY RAAMALQISN IWTRAMFCQQ MGINELPQNC 960
  961 AFFSQVDIDS VIRKEVNMDC ITPSNKTAIP HGEALDINQL LDKSNSKLGK PNLDIDSKVS1020
 1021 QYAYNYREPV FEEYNKSYTP EFLKYFLAMQ VQSDKRDVNR LEDEYLRECT SKEYARDGNT1080
 1081 AEYSLLDYIK DVEKGKRTKV RIMGSNFLDG TKNAKADQRI RLPVNMPDYP TLHKIANDSA1140
 1141 IPEKQLLENR RKKENRIDDE NKKKLTRKKN TTPMERKYKR VYGGRKAFEA FYECANKPLD1200
 1201 YTLETEKQFF NIPIDGVIDD VLNDKSNYKK KPSQARTASS SPIRKTAKAV HSKKLPARKS1260
 1261 STTNRNLVEL ERDITISREY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen BUR2 MIP1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..241] MSA 1.013946 View MSA. No confident structure predictions are available.
    2 View Details [242..393] deduced N/A No confident structure predictions are available.
    3 View Details [394..541]
    [707..722]
    [887..1011]    		 PSI-BLAST 152.0 Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
    4 View Details [542..571]
    [644..706]
    [723..886]    		 PSI-BLAST 152.0 Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
    5 View Details [572..643] PSI-BLAST 152.0 Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
    6 View Details [1012..1280] MSA 1.007859 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • DNA polymerase activity
    		•  7.87431862983329 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  7.78411937387917 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  5.3880945520411 bayes_pls_golite062009
  • exonuclease activity
    		•  2.86892175148145 bayes_pls_golite062009
  • nuclease activity
    		•  2.84202779131927 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.94077739152313 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.87431870698721 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.87430802282815 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.82848379742483 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.75713164321634 bayes_pls_golite062009
  • transferase activity
    		•  1.47288345517763 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • endonuclease activity
    		•  0.935348031740788 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.782108781904855 bayes_pls_golite062009
  • binding
    		•  0.777766550398053 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.77421125364834 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.72566997912926 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.539345587157456 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.48776342704945 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.265266702292727 bayes_pls_golite062009
  • exoribonuclease activity
    		•  0.14466215642144 bayes_pls_golite062009
  • DNA binding
    		•  0.119847375774469 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.0662718964590603 bayes_pls_golite062009
  • protein binding
    		•  0.058257360610363 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle