Protein Overview: TIM18

General Information:
Name(s) found:	TIM18 / YOR297C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|74645012\|sp\|Q08749.1\|TIM18_YEAST RecName: Full=Mitochondrial import inner membrane translocase subunit TIM18; Flags: Precursor [NCBI NR] gi\|6470297\|gb\|AAF13717.1\|AF200324_1 Tim18p [Saccharomyces cerevisiae] [NCBI NR] gi\|6324871\|ref\|NP_014940.1\| Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complex; Tim18p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S67201 hypothetical protein YOR297c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1420658\|emb\|CAA99525.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Mitochondrial import inner membrane translocase subunit TIM18 OS=Saccharomyces cerevisiae GN=TIM18 PE=1 SV=1 [Swiss-Prot] TIM18 Component of the inner mitochondrial membrane translocation complex [mips] Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex [SGD] >Q08749 (Q08749) Chromosome XV reading frame ORF YOR297C [4932.FASTACCERV.txt] Chr XV from 875318-874740, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] Chr XV from 874739-875317, reverse complement [yeastorf3.fasta] Chr XV from 874740-875318, reverse complement [yeastorf4.fasta] TIM18, Chr XV from 874739-875317, reverse complement [yeast_orfs2] TIM18 SGDID:S0005823, Chr XV from 875318-874740, reverse complement, Verified ORF [yeastflysequest.fasta] Tim18p [Saccharomyces cerevisiae]gi\|1420658\|emb\|CAA99525.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|6470297\|gb\|AAF13717.1\| Tim18p [Saccharomyces cerevisiae]gi\|2132121\|pir\|\|S67201 hypothetical protein YOR297c - yeast (Saccharomyces cerevisi [nrdb_11152004_Chlamydomonas] (Q08749) S.cerevisiae chromosome XV reading frame ORF YOR297c (Tim18p) [cerv4932.FASTAC] TIM18 SGDID:S000005823, Chr XV from 875318-874740, reverse complement, Verified ORF, "Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complex" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] TIM18 SGDID:S000005823, Chr XV from 875320-874742, reverse complement, Verified ORF, "Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complex" [yeast-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Import inner membrane translocase subunit TIM18, mitochondrial precursor [nr-271106-contam.fasta] Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complex; Tim18p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Tim18p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] TIM18 SGDID:S000005823, Chr XV from 875320-874742, reverse complement, Verified ORF, "Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] [chemostatdb.fasta]
Organism:	Saccharomyces cerevisiae
Length:	192 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial inner membrane protein insertion complex [IDA]
Biological Process:	protein targeting to mitochondrion [IGI][IPI] protein targeting to membrane [IGI][IPI]
Molecular Function:	protein transporter activity [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLFPGLKPV LNASTVIVNP VRAVFPGLVL STKRSFYSIN RLNAENKIND IANTSKEASS  60
   61 SVQMFKPPEF SQFKDSYQKD YERIAKYTLI PLTMVPFYAS FTGGVINPLL DASLSSIFLI 120
  121 YLQYGFTSCI IDYIPKGKYP RWHKLALYCL YGGSMLSLYG IYELETKNNG FVDLVKKLWN 180
  181 ENDDHLYIFG RN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		TIM12 TIM18 TIM22 TIM23 TIM54

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	NTA1	TIM18	1	Unpublished Fields Lab Data
View Screen	APC5	TIM18	1	Unpublished Fields Lab Data
View Screen	RAD6	TIM18	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	TIM18	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..192]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2