Protein Overview: CAF20

General Information:
Name(s) found:	CAF20 / YOR276W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324850\|ref\|NP_014919.1\| Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E; Caf20p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S67178 translation initiation factor eIF-4E-associated protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|187608863\|sp\|P12962.2\|CAF20_YEAST RecName: Full=Cap-associated protein CAF20; AltName: Full=20 kDa cap-associated protein; AltName: Full=CCR4-associated factor 2; AltName: Full=p20 [NCBI NR] gi\|1420618\|emb\|CAA99501.1\| CAF20 [Saccharomyces cerevisiae] [NCBI NR] gi\|1279702\|emb\|CAA61782.1\| CAP associated protein [Saccharomyces cerevisiae] [NCBI NR] Cap-associated protein CAF20 OS=Saccharomyces cerevisiae GN=CAF20 PE=1 SV=2 [Swiss-Prot] CAF20 mRNA CAP-binding protein (eIF4F), 20K subunit [mips] Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E [SGD] Chr XV from 841330-841815 [hmr_yeast5_DM3-1_pombe.fasta] Chr XV from 841329-841814 [yeastorf3.fasta] CAF20, Chr XV from 841329-841814 [yeast_orfs2] CAF20 SGDID:S0005802, Chr XV from 841330-841815, Verified ORF [yeastflysequest.fasta] Caf20p [Saccharomyces cerevisiae]gi\|1279702\|emb\|CAA61782.1\| CAP associated protein [Saccharomyces cerevisiae]gi\|1420618\|emb\|CAA99501.1\| CAF20 [Saccharomyces cerevisiae]gi\|2133187\|pir\|\|S67178 translation initiation factor eIF-4E-associated protein - yea [nrdb_11152004_Chlamydomonas] CAF20 SGDID:S000005802, Chr XV from 841330-841815, Verified ORF, "Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] CAF20 SGDID:S000005802, Chr XV from 841332-841817, Verified ORF, "Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E" [yeast-contam.fasta] CAF20 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] CAP associated protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E; Caf20p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Cap-associated protein CAF20 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CAF20 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] CAF20 SGDID:S000005802, Chr XV from 841333-841818, Genome Release 64-1-1, Verified ORF, "Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E" [yeast-030211-contam.fasta] CAF20 SGDID:S000005802, Chr XV from 841333-841818, Genome Release 64-2-1, Verified ORF, "Phosphoprotein of the mRNA cap-binding complex; involved in translational control; repressor of cap-dependent translation initiation; competes with eIF4G for binding to eIF4E" [20141208_orf_trans.fasta] YOR276W SGDID:S000005802, Chr XV from 841333-841818, Genome Release 64-1-1, Verified ORF, "Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	161 amino acids
Gene Ontology:
Cellular Component:	mRNA cap binding complex [IPI]
Biological Process:	negative regulation of translation [IGI][IMP]
Molecular Function:	translation regulator activity [IGI][IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKYTIDELF QLKPSLTLEV NFDAVEFRAI IEKVKQLQHL KEEEFNSHHV GHFGRRRSSH  60
   61 HHGRPKIKHN KPKVTTDSDG WCTFEAKKKG SGEDDEEETE TTPTSTVPVA TIAQETLKVK 120
  121 PNNKNISSNR PADTRDIVAD KPILGFNAFA ALESEDEDDE A

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CAF20 CDC33
View Details	(MIPS) Mewes HW, et al. (2004)		CAF20 TIF4631 TIF4632
View Details	Krogan NJ, et al. (2006)		CAF20 CDC33 EAP1 PSP2 SLF1 TIF1, TIF2 TIF4631 TIF4632 YOR287C
View Details	Ho Y, et al. (2002)		CAF20 CDC33 GAL83 NAP1
View Details	Qiu et al. (2008)		CAF20 EAP1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

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	BAIT	PREY	HITS	PUBLICATION
View Screen	NAF1	CAF20	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	CAF20	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..161]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2