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Protein Overview: RTC1

General Information:
Name(s) found: RTC1 / YOL138C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Protein of unknown function; may interact with ribosomes, based on co-purification experiments; null mutation suppresses cdc13-1 temperature sensitivity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1341 amino acids

    Gene Ontology:
    Cellular Component: fungal-type vacuole [IDALink to PubMed article]
    ribosome [IDALink to PubMed article]
    Biological Process: telomere maintenance [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSPHVENA SIPKGSTPIP KNRNVSSIGK GEFLGSSSSN NSSFRMNHYS NSGQPSVLDS  60
   61 IRRPNLTPTF SYSNGVYMPE SHRTSSFNDS YLPYDKNPYA KTTGSMSNKS NMKIKTKKNA 120
  121 INTNTRKSSG LIYTTKVDKE LSSIDKVNDP NINGLVCAGK THLGLYKFSP SDRSIKCVHD 180
  181 FITPNSNTST RGTTSLLPKL SKRTRQNKFS TIADVKTGFN NYKNCIAVCN NSTAISIYDL 240
  241 NKSSSIDNPL ITSLCEHTRS INSFDFNMVE SNLIISGGQD SCVKIWDLRS NKSKSSNRSD 300
  301 ISINTASDSI RDVKWMPGYN FASKNDQGSS TYGNLKSGYK FASIHDSGYL LKFDLRQPAQ 360
  361 YEKKLNAHTG PGLCLNWHPN QEYIATGGRD GKSCLWFVGD NANAAENTVL NYGNSPSLHA 420
  421 PNTSLNNSGS LAFPKLTINT GYPVTKLKFK PAYSSNIYNS LLGISSMGDE AEVRIYSLAR 480
  481 KYIPKHVLLS ETPSLGLVWW DENLIFNIDK GTRINGWDIN KEPTVLENLS KNTTTWRDLD 540
  541 GNGLLSVGQE IGSYEVVEPE LQPTSSTTCK KHPGTIKNPK NGNPENQGII GGIKKGFSHT 600
  601 GLTSFTPERP PTLKAGPTFS TKSLTLASGA SSFNSSSASL TSLTPQTENR EEIAIEPPCI 660
  661 ITLDIPQIFN NIRLTKIAHS RKKNVISESS SMKNSPVEKF KYLARQLKFS YIREHNVSDS 720
  721 ADTAYKNDIE NIDVVKNATE THGDNTTTTN NNDDGDDDDD DDDDDKIIES HLLKKYNFPE 780
  781 NNTWATLMNE KVNNKKSKRN SSSSREFDEK DVRSSISSIS ASRQSHDRAR KIDKNVEAEL 840
  841 QEKIQTLVDL ISIATHNASV YLSIDDLTNF KIWILIRDSL LWDLKWMTSS QISSDNASNM 900
  901 DANESSDFEA GENLKTGKEF PEEDGAGTSG AESLVEERPQ AFRANSDEPS DAEKKPVSKL 960
  961 KEQLKNTEII PYAQPNEDSD EVLTKLKELQ NQRLESRTKM GETVSDDVII EEDEHEHQEE1020
 1021 EQPHDSPTKS AQFHASPIAK SIPILQKREH RKSFIDTFML HSPNGYNGDT DIGNEDDNIS1080
 1081 PRFTYNSVSP RSKVSSLQSY ATTTSQLETF KKLSSHTAPI IGSPRHAPSR PDSIGREQLS1140
 1141 SSLTKKLAKC KKIIADPPWD TKKLIKQLYN QATETGNVVL TVNILFLFQT IYQITEIDIA1200
 1201 KDAIAHFLLL LHRYELFGIA ADVLKYCPFE DIMGSEGDQS SIRLFCERCG ELITNESSKE1260
 1261 KLRAEAQQTG NKKIMDKFGY WYCDSCKKKN TSCVLCERPL KKLTMVILPC GHEGHFQCIQ1320
 1321 EWFLDENEQE CPGGCPGVAF I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RTC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] PSI-BLAST 5.0 TolB, C-terminal domain; TolB, N-terminal domain
    2 View Details [111..438] PSI-BLAST 53.39794 Tup1, C-terminal domain
    3 View Details [439..552] PSI-BLAST 77.154902 beta1-subunit of the signal-transducing G protein heterotrimer
    4 View Details [553..715] MSA 3.702996 View MSA. No confident structure predictions are available.
    5 View Details [716..1129] deduced N/A No confident structure predictions are available.
    6 View Details [1130..1341] MSA 4.008949 View MSA. No confident structure predictions are available.
    7 View Details [1122..1227] deduced N/A No confident structure predictions are available.
    8 View Details [1228..1341] FFAS03 1.03 No description for 2jm1A was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle