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Protein Overview: MON2

General Information:
Name(s) found: MON2 / YNL297C [SGD]
Description(s) found:
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  • gi|6324033|ref|NP_014102.1| Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins; Mon2p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S60403 probable membrane protein YNL297c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1353105|sp|P48563.1|MON2_YEAST RecName: Full=Protein MON2 [NCBI NR]
  • gi|1302387|emb|CAA96214.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1050863|gb|AAC49101.1| Ynl0453p [NCBI NR]
  • Uncharacterized protein YNL297C - Saccharomyces cerevisiae (Baker's yeast) [Swiss-Prot]
  • Protein MON2 OS=Saccharomyces cerevisiae GN=MON2 PE=1 SV=1 [Swiss-Prot]
  • MON2 Peripheral membrane protein with a role in endocytosis and vacuole integrity [mips]
  • Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins [SGD]
  • Chr XIV from 71671-76581, reverse complement [yeastorf3.fasta]
  • Chr XIV from 76581-71671, reverse complement [yeastorf5.fasta]
  • (P48563) Hypothetical 186.8 kDa protein in CLA4-PUS4 intergenic region [4932.FASTACCERV.txt]
  • MON2, Chr XIV from 71671-76581, reverse complement [yeast_orfs2]
  • MON2 SGDID:S0005241, Chr XIV from 76581-71671, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Mon2p [Saccharomyces cerevisiae]gi|1302387|emb|CAA96214.1| unnamed protein product [Saccharomyces cerevisiae]gi|2132786|pir||S60403 probable membrane protein YNL297c - yeast (Saccharomyces cerevisiae)gi|1050863|gb|AAC49101.1| Ynl0453pgi|1353105|sp|P48 [nrdb_11152004_Chlamydomonas]
  • MON2 SGDID:S000005241, Chr XIV from 76583-71673, reverse complement, Verified ORF, "Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Ynl0453p [nr-271106-contam.fasta]
  • Uncharacterized protein YNL297C [nr-271106-contam.fasta]
  • Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins; Mon2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Protein MON2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MON2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MON2 SGDID:S000005241, Chr XIV from 76583-71673, Genome Release 64-1-1, reverse complement, Verified ORF, "Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins" [yeast-030211-contam.fasta]
  • MON2 SGDID:S000005241, Chr XIV from 76583-71673, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins" [20141208_orf_trans.fasta]
  • YNL297C SGDID:S000005241, Chr XIV from 76583-71673, Genome Release 64-1-1, reverse complement, Verified ORF, "Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1636 amino acids

    Gene Ontology:
    Cellular Component: endosome [IDALink to PubMed article]
    cytosol [TASLink to PubMed article]
    extrinsic to membrane [IDALink to PubMed article]
    Biological Process: endocytosis [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    transport [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: guanyl-nucleotide exchange factor activity [IGILink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMNTGGFDS MQRQLEAELR SLSSESKRRN STIRHASDKS IEILKRVHSF EELERHPDFA  60
   61 LPFVLACQSR NAKMTTLAMQ CLQGLSTVPS IPRSRLSEIL DAFIEATHLA MEIQLKVLQV 120
  121 VPIFFKTYGK FIYGPLCKKL LLCCSNLLHV PNKAPVVVGT ASATLQQLID EIFDRLSIES 180
  181 VVDDKQYEVL ISNSESIKVN VYRYDANKLF DNICSLNEIS SNGAVSDEEM LLDIGDIPID 240
  241 YGLEILESIL KNSQKNLLEC QDLQYLLRVK AIPLLLRCIS SSRHFSTAVR SCRCLKLLIR 300
  301 KEYLSILELE LEVILSLLIH GISVESNLSG WQRVLSLELF KDLSQDPEIV NTLYMDYDNY 360
  361 PDKKHVFKYL LKECIVLLNS PEYITFLAPS KVVEKMDSPL ITTENSTVKT KFMHLLDKSN 420
  421 APSINITYII SLILTICNHL CEGLNKSALE SSPLEKKIED KEREEGTGND STVVKVYSGL 480
  481 FSGLFELNKL FLYSTSLETS IFHLVVRAFQ KLAHSAGVLS LKDKLRACMK LFSILITNNV 540
  541 TSSNQYSFND TSKSAKNQHT RNISTSSVTT SPVESTKNPS RSIADSAQNK EMKRRLHPRN 600
  601 ISSRQVSLLR ALISLSISLG PIFDSESWRY TFLTWQWITY YIYGPSADFK ESFYSEDIPP 660
  661 PPILTKSDVT SIESSLTKFF ESTSSYSCST FHLVLTRLIL DSKNTLTLEQ TNLNLNNDIG 720
  721 YHPLDAKDEI IPCIYNKAFF VNKIGELATY NCKKFLFGKN GKELWSLIST YMIKLISNRE 780
  781 MDNDSLRLYT VRVFTDIIKK ATNEVGNSDE QDNKVKQFGT LENLVIDSLM ATINSIKQLD 840
  841 IGKQEIYNGT INVESDILFQ LLLTLKEILN EFGELLMNSW TNIFNIINSP FEWTVEDTDF 900
  901 SVNEDIDDSS LFEGIVQKHK NMIQVSYDVF KLISDDFLQS LPMSVIKFVI DTLVNFVSQK 960
  961 RNLNISFSSI SQFWLVGDYL RVRFNPETLN LSDEKRRSLS EKINNQKLIE IITSSSSHDW1020
 1021 ELYNGLWIYL LKNLINCTND DRVEVKNGAV QTFFRIIDSH SVCFPPWDLI FLEVIEPLLT1080
 1081 KEWSTEELEN ETDFINVTLQ GLIKLYPEHF KDFKNNTTCA KEWSMLLDFL KRLLSSTSNN1140
 1141 TKNAVILNYQ TLLKEIITIE DVPSDILKKC CEIFTDYNIT YSDLSTNASS KTEYDCIYEL1200
 1201 ITGFPPLYQL ISKYDAMTDE FVEKVLLLFN SAIKYPLLPE FVQDKTKPSS MQKAILSGLD1260
 1261 IFMTNDSKDT EILILLQLST ISILAFDTRE KITKKLGPKL PKASLNRLPT FEAISYMSCS1320
 1321 NLRNRIAKID QFGISTLKAK HILRILKNLA EIIKRKSLIT GSESDEIPIW VLASNCFCDL1380
 1381 SNKIFKSLQE DAENPLKDNF CDLFINVIVV TLQRINPELD NLTEIDDLNE YSKYREILLE1440
 1441 NRIIDLFNER QLDTFIYAVW DCSFLYEFDE LENALMQDCG TFSELSQKLS SFDFSCIFGS1500
 1501 TTNPRFQTKY KCSLECLQDL VNFMLNTNEK LRKLTAPYLS ARIALALRRY ISDEYLIGRA1560
 1561 PIPKLRKTEL ATLLNGLCVI LRGVLDQNST LGNKQIGVEN LQTLSPLILR TIPVSHKMDG1620
 1621 LQDKVLELSL GFTKLD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) DOP1 MON2
    View Details Gavin AC, et al. (2006) DOP1 MON2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3906: TAP-tagged Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MON2 and COP1 Huh WK, et al. (2003)
    View Data MON2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220] MSA 1.012976 View MSA. No confident structure predictions are available.
    2 View Details [221..326] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [327..1393] MSA 8.036826 View MSA. No confident structure predictions are available.
    4 View Details [1394..1636] deduced N/A No confident structure predictions are available.
    5 View Details [663..782] FFAS03 1.13 No description for 2ie3A was found.
    6 View Details [783..1559] FFAS03 0.974 AP1 clathrin adaptor core
    7 View Details [1560..1636] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle