Protein Overview: ARK1

General Information:
Name(s) found:	ARK1 / YNL020C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324308\|ref\|NP_014378.1\| Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; Ark1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S62932 hypothetical protein YNL020c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1730058\|sp\|P53974.1\|ARK1_YEAST RecName: Full=Actin-regulating kinase 1 [NCBI NR] gi\|1301849\|emb\|CAA95882.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] (P53974) Probable serine/threonine-protein kinase YNL020C (EC 2.7.1.37) [Swiss-Prot] Actin-regulating kinase 1 OS=Saccharomyces cerevisiae GN=ARK1 PE=1 SV=1 [Swiss-Prot] ARK1 Actin Regulating Kinase [mips] Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis [SGD] ARK1, Chr XIV from 595619-597535, reverse complement [yeast_orfs2] Chr XIV from 595619-597535, reverse complement [yeastorf3.fasta] Chr XIV from 597535-595619, reverse complement [yeastorf5.fasta] ARK1 SGDID:S0004965, Chr XIV from 597537-595621, reverse complement, Verified ORF [yeastflysequest.fasta] ARK1 SGDID:S0004965, Chr XIV from 597538-595622, reverse complement, Verified ORF [10112005cervSGD.fasta] Ark1p [Saccharomyces cerevisiae]gi\|1301849\|emb\|CAA95882.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1730058\|sp\|P53974\|KNC0_YEAST Probable serine/threonine-protein kinase YNL020Cgi\|2131863\|pir\|\|S62932 hypothetical protein YNL020c - yeast (Sa [nrdb_11152004_Chlamydomonas] ARK1 SGDID:S000004965, Chr XIV from 597540-595624, reverse complement, Verified ORF, "Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Actin-regulating kinase 1 [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; Ark1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ARK1 SGDID:S000004965, Chr XIV from 597541-595625, reverse complement, Verified ORF, "Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] [chemostatdb.fasta] Actin-regulating kinase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARK1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ARK1 SGDID:S000004965, Chr XIV from 597539-595623, Genome Release 64-1-1, reverse complement, Verified ORF, "Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis" [yeast-030211-contam.fasta] ARK1 SGDID:S000004965, Chr XIV from 597539-595623, Genome Release 64-2-1, reverse complement, Verified ORF, "Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] TR153\|c0_g1_i1\|g.93 ORF TR153\|c0_g1_i1\|g.93 TR153\|c0_g1_i1\|m.93 type:complete len:639 (+) TR153\|c0_g1_i1:141-2057(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YNL020C SGDID:S000004965, Chr XIV from 597539-595623, Genome Release 64-1-1, reverse complement, Verified ORF, "Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_6264\|g.3807 ORF ID=asmbl_6264\|g.3807 ID=asmbl_6264\|m.3807 type:complete len:639 (+) ID=asmbl_6264:140-2056(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	638 amino acids
Gene Ontology:
Cellular Component:	actin cortical patch [IDA]
Biological Process:	cytokinesis [IMP] actin filament organization [IGI][IMP] regulation of endocytosis [IMP] protein amino acid phosphorylation [IMP][ISS] actin cortical patch assembly [TAS]
Molecular Function:	protein serine/threonine kinase activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQPQIGTYN VGTQLTVGSH QVEIIKYLTS GGFAQVYSAL INPPDPHSNS SVACLKRVIV  60
   61 PDKPSLNTLR AEVDAMRLLK NNRYVVSYID SHAAKAMLHN GSYEVFVLME YCERGGLIDF 120
  121 MNTRLQNRLH EFEILQIMSQ VTQGVAAMHA LQPPLIHRDI KIENVLISAN NEYKLCDFGS 180
  181 VCGIIRPPRN SQELSYVQQD ILKNTTAQYR SPEMIDTFRG LPIDEKSDIW ALGIFLYKLC 240
  241 YYTTPFEKGG DLAILSGKFE FPLYPNYSEQ LKGLIRDILV QDPRHRPNVY QLLKRISIMQ 300
  301 NVPCPINDIQ VVQAPSSHLN LTELHQLSAT QNILSLNSPT TMENTMPNAT FQISMADNTT 360
  361 TAQMHPNRKP SQIAYDASFS NSAKGSQPLF DKSQNMYHAL DPPLVEPLAS SVSNNDNELK 420
  421 ANSATKLKQA IVSEAHTFRQ NNSIDFPLQN IIPQYEDSSS SSDESYSGDV DELKKTRSLG 480
  481 SYSTRGNIKK NQSVKESLTS SSLPGTSFTP TSTKVNLKHE NSPFKSTFVN TIDNSKDDLN 540
  541 KPSYEDLDVS KQNLKNSIQQ RMIDKLNSSE ESFNARKMSK VKLHEKGEID KPTMLKSSGP 600
  601 ISKDKKTKPT PPPKPSHLKP KPPPKPLLLA GRKLSLDK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		ARK1 CLA4 ENT1 PRK1 SLA1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	ARK1 and SAC6	Huh WK, et al. (2003)
View Data	ARK1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..70] [89..110]	PSI-BLAST	221.741366	gamma-subunit of glycogen phosphorylase kinase (Phk)
2	View Details	[71..88] [111..335]	PSI-BLAST	221.741366	gamma-subunit of glycogen phosphorylase kinase (Phk)
3	View Details	[336..414]	PSI-BLAST	12.0	Calmodulin
4	View Details	[415..521]	PSI-BLAST	12.0	Calmodulin
5	View Details	[522..638]	deduced	N/A	No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: ARK1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: