Protein Overview: LIP1

General Information:
Name(s) found:	LIP1 / YMR298W [SGD]
Description(s) found: Found 23 descriptions. SHOW ALL	Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis [SGD]
Organism:	Saccharomyces cerevisiae
Length:	150 amino acids
Gene Ontology:
Cellular Component:	nuclear envelope [IDA] endoplasmic reticulum membrane [IDA] endoplasmic reticulum [IDA]
Biological Process:	ceramide biosynthetic process [IMP][IPI]
Molecular Function:	sphingosine N-acyltransferase activity [IMP][IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQPTPIITT KSAAKPKPKI FNLFRVCFIS LLLIAAVEYF KYGTRINYEW FHCTPIKEPQ  60
   61 SGSVIKLWAR GGPSCDKRGE YKTIVKRITR DYEPNDEHLS FCIIENDNVP PVHYPIHEDK 120
  121 GEPGYVAYVG YDTDSELVQE LCADSTIYHM

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		LAC1 LCB1 LIP1 SUR4

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	ROM1	LIP1	1	Unpublished Fields Lab Data
View Screen	LSM8	LIP1	1	Unpublished Fields Lab Data
View Screen	LOS1	LIP1	1	Unpublished Fields Lab Data
View Screen	CUS1	LIP1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	LIP1 and SPC42	Hazbun TR, et al. (2003)
View Data	LIP1 and TRX3	Hazbun TR, et al. (2003)
View Data	LIP1	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..150]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2