Protein Overview: TRI1

General Information:
Name(s) found:	TRI1 / YMR233W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|887614\|emb\|CAA90204.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|6323889\|ref\|NP_013960.1\| Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; Tri1 [NCBI NR] gi\|45269842\|gb\|AAS56301.1\| YMR233W [Saccharomyces cerevisiae] [NCBI NR] gi\|2497196\|sp\|Q05024.1\|TRI1_YEAST RecName: Full=Protein TRI1 [NCBI NR] pir\|\|S57600 hypothetical protein YMR233w - yeast (Saccharomyces cerevisiae) [NCBI NR] Uncharacterized protein YMR233W OS=Saccharomyces cerevisiae GN=YMR233W PE=1 SV=1 [Swiss-Prot] Protein TRI1 OS=Saccharomyces cerevisiae GN=TRI1 PE=1 SV=1 [Swiss-Prot] Protein of unknown function localised to cytoplasm and nucleus [mips] Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus [SGD] YMR233W, Chr XIII from 739184-739864 [yeast_orfs2] Chr XIII from 739184-739864 [yeastorf3.fasta] (Q05024) Hypothetical 26.5 kDa protein in FUS2-RNH1 intergenic region [4932.FASTACCERV.txt] YMR233W SGDID:S0004846, Chr XIII from 739184-739864, Uncharacterized ORF [yeastflysequest.fasta] Interacts with Top1p in 2-hybrid assay. [Saccharomyces cerevisiae]gi\|887614\|emb\|CAA90204.1\| unknown [Saccharomyces cerevisiae]gi\|45269842\|gb\|AAS56301.1\| YMR233W [Saccharomyces cerevisiae]gi\|1362399\|pir\|\|S57600 hypothetical protein YMR233w - yeast (Sacc [nrdb_11152004_Chlamydomonas] YMR233W SGDID:S000004846, Chr XIII from 739184-739864, Uncharacterized ORF, "Interacts with Top1p in 2-hybrid assay." [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YMR233W SGDID:S000004846, Chr XIII from 739184-739864, Uncharacterized ORF, "Protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nuc [yeast-contam.fasta] TRI1 SGDID:S000004846, Chr XIII from 739184-739864, Verified ORF, "Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] YMR233W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Hypothetical 26.5 kDa protein in FUS2-RNH1 intergenic region [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene; Ymr233wp [Saccharomyces [nr-271106-contam.fasta] TRI1 SGDID:S000004846, Chr XIII from 739184-739864, Verified ORF, "Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus" [yeast-bovrabprots.fasta] YMR233W SGDID:S000004846, Chr XIII from 739184-739864, Uncharacterized ORF, "Protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; YMR233W is not an essential gene" [yeast-contam_custom.fasta] [chemostatdb.fasta] Protein TRI1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRI1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] TRI1 SGDID:S000004846, Chr XIII from 739185-739865, Genome Release 64-1-1, Verified ORF, "Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus" [yeast-030211-contam.fasta] TRI1 SGDID:S000004846, Chr XIII from 739185-739865, Genome Release 64-2-1, Verified ORF, "Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YMR233W SGDID:S000004846, Chr XIII from 739185-739865, Genome Release 64-1-1, Verified ORF, "Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	226 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA] nucleolus [IDA]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADINKYIPM VDAILSVSNP DEISPKRVRK ALQILYSVNL DSQRKLINEL ILERFGDIQE  60
   61 NPRVLIPKND LISRDQELSL RLQKEEERPL RSTRKRKGKS ESKSKRKKKK NDSPDSNSIS 120
  121 VRKVLLSAPL QKFLGSEELP RTQVVKMIWQ YIKEHDLQNP KDRREILCDE KMEPIFGKKM 180
  181 TMFSMNKLLT KHLFNPDEIV KHEEEQKQTP EKEIKLENES LPNLSG

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		HIF1 SAP4 SPT2 TRI1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	HSL7	No Comments	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PET111	TRI1	2	Unpublished Fields Lab Data
View Screen	RAD51	TRI1	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	TRI1 and NOP56	Huh WK, et al. (2003)
View Data	TRI1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..84]	MSA	7.038991	View MSA. No confident structure predictions are available.
2	View Details	[85..226]	Pfam	51.017729	SWIB/MDM2 domain No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
binding	2.63842828741542	bayes_pls_golite062009
transcription regulator activity	2.62775554429027	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.953438255689584	bayes_pls_golite062009
histone binding	0.948950535074526	bayes_pls_golite062009
protein binding	0.529408559970229	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.439630834571696	bayes_pls_golite062009

Term	Confidence	Notes
transcription regulator activity	4.01592136607858	bayes_pls_golite062009
binding	3.20303599400601	bayes_pls_golite062009
basal transcription repressor activity	2.69162769894095	bayes_pls_golite062009
transcription coactivator activity	2.58234407051051	bayes_pls_golite062009
transcription repressor activity	1.98538788872171	bayes_pls_golite062009
transcription activator activity	1.83085389017135	bayes_pls_golite062009
transcription factor binding	1.73032563380905	bayes_pls_golite062009
transcription cofactor activity	1.60414428986898	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.51390743508971	bayes_pls_golite062009
protein binding	1.38134467541454	bayes_pls_golite062009
ligase activity	0.802664465339603	bayes_pls_golite062009
structural molecule activity	0.66106995897056	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.15313128037113	bayes_pls_golite062009
catalytic activity	0.121624777548864	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2