YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: ERG12

General Information:
Name(s) found: ERG12 / YMR208W [SGD]
Description(s) found:
Found 27 descriptions.
SHOW ALL
  • Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 443 amino acids

    Gene Ontology:
    Cellular Component: cytosol [TAS]
    Biological Process: ergosterol biosynthetic process [TAS]
    Molecular Function: mevalonate kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPFLTSAP GKVIIFGEHS AVYNKPAVAA SVSALRTYLL ISESSAPDTI ELDFPDISFN  60
   61 HKWSINDFNA ITEDQVNSQK LAKAQQATDG LSQELVSLLD PLLAQLSESF HYHAAFCFLY 120
  121 MFVCLCPHAK NIKFSLKSTL PIGAGLGSSA SISVSLALAM AYLGGLIGSN DLEKLSENDK 180
  181 HIVNQWAFIG EKCIHGTPSG IDNAVATYGN ALLFEKDSHN GTINTNNFKF LDDFPAIPMI 240
  241 LTYTRIPRST KDLVARVRVL VTEKFPEVMK PILDAMGECA LQGLEIMTKL SKCKGTDDEA 300
  301 VETNNELYEQ LLELIRINHG LLVSIGVSHP GLELIKNLSD DLRIGSTKLT GAGGGGCSLT 360
  361 LLRRDITQEQ IDSFKKKLQD DFSYETFETD LGGTGCCLLS AKNLNKDLKI KSLVFQLFEN 420
  421 KTTTKQQIDD LLLPGNTNLP WTS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ERG12 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..11]
    [33..209]
    [393..443]    		 PSI-BLAST 415.30103 Mevalonate kinase
    2 View Details [12..32]
    [210..392]    		 PSI-BLAST 415.30103 Mevalonate kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.57444343595083 bayes_pls_golite062009
  • kinase activity
    		•  2.45533953107206 bayes_pls_golite062009
  • diphosphomevalonate decarboxylase activity
    		•  2.34245588421319 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.31269308415192 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.15678581504347 bayes_pls_golite062009
  • structural molecule activity
    		•  1.96296069933386 bayes_pls_golite062009
  • transferase activity
    		•  1.44847475955289 bayes_pls_golite062009
  • binding
    		•  1.2798849549944 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.883371890137341 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.867052243938111 bayes_pls_golite062009
  • catalytic activity
    		•  0.836142537655721 bayes_pls_golite062009
  • DNA binding
    		•  0.541263136605045 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  0.49664490095304 bayes_pls_golite062009
  • protein binding
    		•  0.191135371876197 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle