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View Structure Prediction Details

Protein: ERG12
Organism: Saccharomyces cerevisiae
Length: 443 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG12.

Description E-value Query
Range		 Subject
Range
KIME_YEAST - Mevalonate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG12 PE=1 SV=1
ERG12 - Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from m...
 0.0 [1..443] [1..443]
gi|450346 - gi|450346|emb|CAA53059.1| unnamed protein product [Hepatitis B virus]
gi|450346|emb|CA... - unnamed protein product [Hepatitis B virus]
 2.0E-66 [1..409] [163..551]
gi|32404644, gi|... - gi|32404644|ref|XP_322935.1| hypothetical protein ( (AL513444) related to MEVALONATE KINASE [Neurosp...
gi|85102580 - gi|85102580|ref|XP_961360.1| hypothetical protein NCU03633 [Neurospora crassa OR74A]
 1.0E-65 [1..399] [76..470]
KIME_MOUSE - Mevalonate kinase OS=Mus musculus GN=Mvk PE=1 SV=1
 2.0E-64 [1..409] [2..390]
KIME_RAT - Mevalonate kinase OS=Rattus norvegicus GN=Mvk PE=1 SV=1
 2.0E-64 [1..409] [2..390]
GALK1_CANLF - Galactokinase OS=Canis lupus familiaris GN=GALK1 PE=2 SV=1
 6.0E-59 [3..400] [28..391]
GAL1_BACSU - Galactokinase OS=Bacillus subtilis (strain 168) GN=galK PE=3 SV=1
gi|221316111 - gi|221316111|ref|ZP_03597916.1| galactokinase [Bacillus subtilis subsp. subtilis str. NCIB 3610]
GAL1_BACSU - Galactokinase OS=Bacillus subtilis GN=galK PE=3 SV=1
gi|221321023 - gi|221321023|ref|ZP_03602317.1| galactokinase [Bacillus subtilis subsp. subtilis str. JH642]
gi|221325307 - gi|221325307|ref|ZP_03606601.1| galactokinase [Bacillus subtilis subsp. subtilis str. SMY]
 7.0E-59 [5..399] [20..387]
GAL1_FUSNN - Galactokinase OS=Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / CIP 101130 / JCM 8532...
GAL1_FUSNN - Galactokinase OS=Fusobacterium nucleatum subsp. nucleatum GN=galK PE=3 SV=1
 9.0E-59 [3..396] [18..385]

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Predicted Domain #1
Region A:
Residues: [1-11] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLPFLTSAP G

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [33-209] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SALRTYLLIS ESSAPDTIEL DFPDISFNHK WSINDFNAIT EDQVNSQKLA KAQQATDGLS  60
   61 QELVSLLDPL LAQLSESFHY HAAFCFLYMF VCLCPHAKNI KFSLKSTLPI GAGLGSSASI 120
  121 SVSLALAMAY LGGLIGSNDL EKLSENDKHI VNQWAFIGEK CIHGTPSGID NAVATYG

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [393-443] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTGCCLLSAK NLNKDLKIKS LVFQLFENKT TTKQQIDDLL LPGNTNLPWT S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 415.30103
Match: 1kvkA_
Description: Mevalonate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 2.57444343595083 bayes_pls_golite062009
kinase activity 2.45533953107206 bayes_pls_golite062009
diphosphomevalonate decarboxylase activity 2.34245588421319 bayes_pls_golite062009
structural constituent of ribosome 2.31269308415192 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.15678581504347 bayes_pls_golite062009
structural molecule activity 1.96296069933386 bayes_pls_golite062009
transferase activity 1.44847475955289 bayes_pls_golite062009
binding 1.2798849549944 bayes_pls_golite062009
nucleic acid binding 0.883371890137341 bayes_pls_golite062009
transcription regulator activity 0.867052243938111 bayes_pls_golite062009
catalytic activity 0.836142537655721 bayes_pls_golite062009
DNA binding 0.541263136605045 bayes_pls_golite062009
carbohydrate kinase activity 0.49664490095304 bayes_pls_golite062009
protein binding 0.191135371876197 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [12-32] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVIIFGEHSA VYNKPAVAAS V

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [210-392] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NALLFEKDSH NGTINTNNFK FLDDFPAIPM ILTYTRIPRS TKDLVARVRV LVTEKFPEVM  60
   61 KPILDAMGEC ALQGLEIMTK LSKCKGTDDE AVETNNELYE QLLELIRINH GLLVSIGVSH 120
  121 PGLELIKNLS DDLRIGSTKL TGAGGGGCSL TLLRRDITQE QIDSFKKKLQ DDFSYETFET 180
  181 DLG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 415.30103
Match: 1kvkA_
Description: Mevalonate kinase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle